Motegrity

The active ingredient in Motegrity is prucalopride. Prucalopride is a serotonin-4 (5-HT4) receptor agonist that stimulates colonic peristalsis or contractions in the gastrointestinal tract. This improves motility and provides symptom relief.

Motegrity is typically used if first-line options do not provide relief. Other treatment options for CIC, if first-line options fail, include Linzess (linaclotide) and Amitiza (lubiprostone).

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Motegrity. However, the following is a synopsis of the general guidelines for the use of Motegrity:

• Typically, Motegrity is taken once daily with or without food.
• Use exactly as prescribed. Do not exceed the recommended dose or duration of use.
• If you have a kidney problem, you may need to take a lower dose to reduce the risk of adverse reactions.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
• It is unknown whether Motegrity is safe and effective in pediatric patients.

The most common side effects of Motegrity seen in clinical trials include:

• Headache
• Abdominal pain
• Nausea
• Vomiting
• Diarrhea
• Bloating
• Flatulence
• Dizziness
• Fatigue

Some individuals may experience serious side effects while using Motegrity. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Symptoms of an allergic reaction such as difficulty breathing, rash, itchiness, hives, or swelling of the face, eyes, or lips
• Unusual changes in your mood or behaviors, including worsening depression and suicidal thoughts or behaviors

These are not all of the possible side effects of Motegrity. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Motegrity, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• A history of depression, suicidal thoughts, or other mood problems
• Kidney problems
• Are pregnant or plan to become pregnant
• Are breastfeeding or plan to breastfeed

Do not use Motegrity if you have:

• An allergy to Motegrity
• Intestinal perforation (tear) or obstruction (blockage), including in the stomach or intestines
• Inflammatory GI diseases (ulcerative colitis, Crohn’s disease, toxic megacolon/megarectum)

It typically takes a few weeks of regular use to see the benefits of Motegrity. However, everyone is different and some may see benefits within days of use.

When Motegrity is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions.

Motegrity is available in the following strengths:

• 1 mg
• 2 mg

Motegrity should be stored at room temperature away from light and out of reach of children. Keep Motegrity in its original container to protect it from moisture.

Motegrity is manufactured by the pharmaceutical company Takeda Pharmaceuticals.

Yes, there are generic versions of the brand name Motegrity available.

Consult your doctor or pharmacist before starting, stopping, or changing medications while taking Motegrity. Stopping it abruptly may worsen the symptoms of your condition.

It is unknown if Motegrity can harm your unborn child. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Prucalopride can pass into the breast milk but it is not known what effects it may have on your breastfed child or milk production. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.