Motegrity

(Prucalopride Succinate)

Motegrity (prucalopride) is a prescription used in the treatment of chronic idiopathic constipation (CIC). It helps to promote bowel movements providing symptom relief. Motegrity is typically used when other medications used to treat constipation (such as laxatives) have not provided relief.

Currently, Motegrity does not have FDA approval for irritable bowel syndrome with constipation (IBS-C), but it is sometimes used off-label for this purpose.

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Brand Versions

Motegrity Prescription Required

Strength
1mg
Country
New Zealand
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Marketed as Resotrans in New Zealand

Motegrity Prescription Required

Strength
2mg
Country
Canada
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Marketed as Resotran in Canada

Generic Versions
What are generics?

Prucalopride Succinate Prescription Required

Strength
1mg
Country
India
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Marketed as Pruease 1 in India

Also available from United Kingdom
Strength
1mg
Country
United Kingdom
Select Quantity

Marketed as Prucalopride in United Kingdom

Prucalopride Succinate Prescription Required

Strength
2mg
Country
India
Select Quantity

Marketed as Pruease 2 in India

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Important information about Motegrity

How does Motegrity work?

The active ingredient in Motegrity is prucalopride. Prucalopride is a serotonin-4 (5-HT4) receptor agonist that stimulates colonic peristalsis or contractions in the gastrointestinal tract. This improves motility and provides symptom relief.

Motegrity is typically used if first-line options do not provide relief. Other treatment options for CIC, if first-line options fail, include Linzess (linaclotide) and Amitiza (lubiprostone).

How do you use Motegrity?

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Motegrity. However, the following is a synopsis of the general guidelines for the use of Motegrity:

  • Typically, Motegrity is taken once daily with or without food.
  • Use exactly as prescribed. Do not exceed the recommended dose or duration of use.
  • If you have a kidney problem, you may need to take a lower dose to reduce the risk of adverse reactions.
  • If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
  • It is unknown whether Motegrity is safe and effective in pediatric patients.

What are the side effects of Motegrity?

The most common side effects of Motegrity seen in clinical trials include:

  • Headache
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Bloating
  • Flatulence
  • Dizziness
  • Fatigue

Some individuals may experience serious side effects while using Motegrity. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Symptoms of an allergic reaction such as difficulty breathing, rash, itchiness, hives, or swelling of the face, eyes, or lips
  • Unusual changes in your mood or behaviors, including worsening depression and suicidal thoughts or behaviors

These are not all of the possible side effects of Motegrity. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

What are the warnings or precautions for Motegrity?

Before starting Motegrity, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

  • A history of depression, suicidal thoughts, or other mood problems
  • Kidney problems
  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed

Are there any contraindications with Motegrity?

Do not use Motegrity if you have:

  • An allergy to Motegrity
  • Intestinal perforation (tear) or obstruction (blockage), including in the stomach or intestines
  • Inflammatory GI diseases (ulcerative colitis, Crohn’s disease, toxic megacolon/megarectum)

How long does it take Motegrity to work?

It typically takes a few weeks of regular use to see the benefits of Motegrity. However, everyone is different and some may see benefits within days of use.

What interacts with Motegrity?

When Motegrity is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions.

What doses of Motegrity are available?

Motegrity is available in the following strengths:

  • 1 mg
  • 2 mg

How do I store Motegrity?

Motegrity should be stored at room temperature away from light and out of reach of children. Keep Motegrity in its original container to protect it from moisture.

Which pharmaceutical company manufactures Motegrity?

Motegrity is manufactured by the pharmaceutical company Takeda Pharmaceuticals.

Is there a generic version of Motegrity?

Yes, there are generic versions of the brand name Motegrity available.

How do I stop taking Motegrity?

Consult your doctor or pharmacist before starting, stopping, or changing medications while taking Motegrity. Stopping it abruptly may worsen the symptoms of your condition.

Can Motegrity be used if I am pregnant?

It is unknown if Motegrity can harm your unborn child. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Can Motegrity be used if I am breast feeding?

Prucalopride can pass into the breast milk but it is not known what effects it may have on your breastfed child or milk production. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.

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Important information about buying Motegrity from UniversalDrugstore™

What happens after I place my order for Motegrity with Universal Drugstore?

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

How long does it take to process and deliver my order for Motegrity?

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Can I track my order of Motegrity?

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

What should I do if there is an issue with my order for Motegrity?

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

How is my medication packaged to ensure privacy and safety?

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Does Universal Drugstore ship medications that require refrigeration or special handling?

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

What are the shipping costs, and does Universal Drugstore offer free delivery?

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Does Universal Drugstore accept Medicare or Medicaid for prescriptions?

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Can I use private health insurance to cover my prescription from Universal Drugstore?

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Unievrsal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

How secure is my payment information when ordering from Universal Drugstore?

We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.

Can I order a generic alternative to Motegrity?

Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

Do I need a prescription to order Motegrity?

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription.

Can I order multiple medications at once?

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Can I refill my prescription through Universal Drugstore?

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Does Universal Drugstore offer discounts or price matching?

Yes! We offer:

  • Up to 80% savings on medications
  • Price match guarantee – we’ll match competitor pricing on qualifying medications
  • 10% off your first order for new customers

How can I contact Universal Drugstore for additional support?

We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.

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Important

The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.