Neomycin

The active ingredient is neomycin sulfate. It works by binding to the 30s ribosomal subunit, which interrupts the synthesis of bacterial proteins. Also, it mostly targets gram-negative bacteria.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Neomycin. However, the following is a synopsis of the general guidelines for the use of Neomycin:

• This medication can be taken several times a day and should be taken with a full glass of water.
• If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose.

The most common side effects of Neomycin include:

• Nausea
• Diarrhea
• Vomiting

Some individuals may experience serious side effects while using Neomycin. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Severe allergic reaction: swelling of lips and face, or difficulty breathing
• Hearing loss or ototoxicity
• Nerve damage
• Kidney damage, including nephrotoxicity

These are not all of the possible side effects of Neomycin. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Neomycin, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you have:

• Inflammatory gastrointestinal conditions, including ulcerative colitis, inflammatory bowel disease
• Parkinson’s disease
• Kidney disease
• Myasthenia gravis
• History of allergy to medication
• Blockage in the gastrointestinal tract
• Stomach ulcers

Boxed Warning

• Patients taking neomycin should be closely monitored for neurotoxicity, ototoxicity, and nephrotoxicity even when used in recommended doses. The risk is increased in those with impaired kidney function or in those taking high doses and/or for long periods. Avoid concurrent use with other nephrotoxic agents or diuretics such as ethacrynic acid or furosemide.

• Known allergy to Neomycin or any of its inactive ingredients
• Known allergy to medications in the same drug class, including streptomycin, paromomycin, or kanamycin
• Bowel obstruction
• Stomach ulcer or a GI inflammatory problem

This medication will take a few days to begin working.

When Neomycin is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Methotrexate
• Blood thinners, including warfarin
• Digoxin
• NSAIDs
• Aminoglycoside antibiotics, including tobramycin, amikacin, and gentamicin
• Vitamin B12
• Diuretics including furosemide
• Fluorouracil

The dosage forms of Neomycin include oral neomycin tablets, eyedrops, and topical formulations as creams or ointments. Neomycin is available in 500 mg oral tablets.

This antibacterial should be stored at room temperature and out of the reach of children.

The pharmaceutical company that manufactures Neomycin is Taro Pharmaceutical Industries Ltd.

There are lower-cost alternatives for the brand names Neomycin and Neo-Fradin.

This medication can be stopped without tapering, but it should be discussed with your doctor.

Neomycin may cause harm to the unborn child and is not typically recommended during pregnancy. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is unknown whether Neomycin goes into your breast milk, but it is generally not recommended to use it if you are breastfeeding. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.