Nicorette Nasal Spray

(Nicotine)

The active ingredient in Nicorette Nasal Spray is nicotine. It provides small amounts of nicotine without the harmful chemicals in cigarette smoke and other nicotine-containing products. This is helpful for people who experience sudden or intense nicotine cravings and need rapid craving relief when quitting smoking.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Nicorette Nasal Spray. However, the following is a synopsis of the general guidelines for the use of Nicorette Nasal Spray:

• Each dose of Nicorette Nasal Spray usually consists of one spray into each nostril.
• Use the spray when cravings occur, especially during the early stages of quitting. Start with the lowest effective number of doses and increase only if cravings are not controlled. You can use one spray in each nostril up to twice an hour.
• Do not inhale, sniff deeply, or swallow while spraying. This helps reduce throat irritation and improves absorption in the nasal passages. Avoid tilting your head back during use.
• Regular use is often recommended during the first weeks of quitting, followed by gradual reduction.
• Do not eat or drink immediately before or after using the spray, as this may worsen irritation.

Some mild or common side effects of Nicorette Nasal Spray seen in clinical trials as compared to placebo include:

• Nasal irritation or burning.
• Sneezing shortly after use.
• Blocked or runny nose.
• Watery eyes.
• Throat irritation or cough.
• Mild headache.

Some individuals may experience serious side effects while using Nicorette Nasal Spray. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Chest pain or worsening angina.
• Fast or irregular heartbeat.
• Severe or ongoing nosebleeds.
• Signs of an allergic reaction, such as swelling of the face, lips, tongue, or throat.
• Severe dizziness or fainting.
• High blood pressure symptoms, such as severe headache or blurred vision.

These are not all of the possible side effects of Nicorette Nasal Spray. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Nicorette Nasal Spray, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Heart disease, including a recent heart attack or angina.
• High blood pressure that is not well controlled.
• Irregular heartbeat or other heart rhythm problems.
• Nasal conditions such as chronic nasal irritation, nasal polyps, or frequent nosebleeds.
• Asthma or breathing problems.
• Stomach ulcers.
• Diabetes, as nicotine may affect blood sugar levels.
• Overactive thyroid or adrenal gland disorders.

• Allergic to nicotine or any of the ingredients in the spray.
• Do not currently use tobacco or nicotine products.
• Have severe nasal conditions that prevent safe use of nasal sprays unless advised by a healthcare professional.

Nicorette Nasal Spray is considered fast-acting. Nicotine is absorbed quickly through the nasal passages, and craving relief can begin within minutes. This quick relief makes it useful for sudden or strong nicotine cravings during a quit-smoking attempt.

When Nicorette Nasal Spray is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Other nicotine replacement therapy products, like nicotine gum, lozenges, and patches, may increase the risk of nicotine overdose.
• Medications affected by changes in smoking status, as quitting smoking can alter how some drugs are processed in the body.

Nicorette Nasal Spray is available in a 10 mL bottle containing 10 mg/ml of nicotine. Each spray contains 0.5 mg of nicotine.

It should be stored at room temperature, away from the reach of children or pets.

Nicorette Nasal Spray is manufactured by McNeil Products.

Nicorette Nasal Spray is a brand-name product. Generic nicotine nasal sprays may be available depending on the country and regulatory approvals.

Nicorette Nasal Spray should be stopped gradually. As nicotine cravings and withdrawal symptoms decrease, reduce the number of doses used each day. Sudden stopping may increase nicotine withdrawal symptoms. A healthcare professional can help create a step-down plan to support long-term smoke-free success.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. Smoking during pregnancy carries serious risks, and a healthcare professional can help weigh the benefits and risks of nicotine replacement therapy during pregnancy.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. Nicotine can pass into breast milk, and a healthcare professional can advise on the safest options for smoking cessation during breastfeeding.