Orilissa
Orilissa (elagolix) is used in the treatment of endometriosis-associated pain. Endometriosis is a condition wherein endometrial cells can grow in places other than the lining of the womb. This can cause painful periods (dysmenorrhea), pain during intercourse (dyspareunia), or abdominal pain during other times of the month.
Orilissa is taken once or twice daily, and its main side effects include hot flashes, headaches, and nausea.
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Orilissa brand
Orilissa 150mgPrescription Required
Elagolix Sodium (generic Orilissa)
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Important information about Orilissa
How does Orilissa work?
The active ingredient in Orilissa is elagolix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. Endometriosis pain is caused by bleeding and scarring due to the breakdown of endometrial tissues outside of the womb. The buildup of these tissues is caused by estrogen, and the breakdown is caused by drops in estrogen levels.
Elagolix reduces the amount of estrogen in the body to prevent the buildup and breakdown of these tissues. This treats symptoms of endometriosis like severe pain during and between periods, heavy menstrual bleeding, pain during sex, abdominal pain, and pelvic pain.
How do you use Orilissa?
Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Orilissa. However, the following is a synopsis of the general guidelines for the use of Orilissa:
-Your doctor may require you to do a pregnancy test to confirm you are not pregnant before starting Orilissa.
-Then, take Orilissa at the same time every day with or without food.
The usual dose for Orilissa is 150 mg once daily or 200 mg twice daily, depending on what you are treating.
You should be taking an effective method of contraception while you are taking Orilissa. The contraceptive method should not contain estrogen; for example, consider non-hormonal contraceptives or progesterone-only oral contraceptives containing norethindrone.
What are the side effects of Orilissa?
Some mild or common side effects of Orilissa seen in clinical trials as compared to placebo include:
-Hot flashes and night sweats
-Headache, dizziness
-Nausea
-Diarrhea, constipation
-Difficulty sleeping
-Mood swings, mood changes, anxiety, depression, or irritability
-Weight gain
-Joint pain
-Decreased libido (sex drive)
-Changes in your periods, including amenorrhea (no bleeding), irregular bleeding, spotting, increased bleeding, or decreased bleeding
Some individuals may experience serious side effects while using Orilissa. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:
-Suicidal thoughts, actions, or behavior, and worsening of mood.
-Yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, and nausea or vomiting. These may be signs of liver problems.
-Decreased bone mineral density and bone loss with long-term use.
-Swelling of the face, tongue, or throat, difficulty breathing, hives, vomiting, and dizziness. These may be signs of a serious allergic reaction.
These are not all of the possible side effects of Orilissa. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.
What are the warnings or precautions for Orilissa?
Orilissa is not intended for birth control purposes. It will not prevent pregnancy.
Before starting Orilissa, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:
-Osteoporosis or a family history of osteoporosis (weak bones). Orilissa may cause loss of minerals from your bones, resulting in bone loss or decreased bone mineral density.
-Liver problems, or if you consume alcohol excessively or smoke.
-A mental health diagnosis, or a history of depressive or suicidal thoughts.
-Plans to get pregnant to breastfeed.
Are there any contraindications with Orilissa?
Orilissa is contraindicated in people who:
-Are allergic to elagolix or other inactive ingredients from the formulation.
-Are pregnant.
-Have severe liver disease.
-Have osteoporosis.
-Take cyclosporine or gemfibrozil, or other medications that inhibit the organic anion transporting polypeptide (OATP) 1B1 transporter.
-Are under 18 years of age.
How long does it take Orilissa to work?
It may take 1 month to see the benefits from Orilissa.
What interacts with Orilissa?
When Orilissa is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:
-Gemfibrozil
-Cyclosporine
-Hormonal contraceptives; your doctor may require you to change your birth control pills since the combination may increase the side effects of birth control containing estrogens like ethinyl estradiol
-Digoxin
-Rifampin
-Rosuvastatin
-Omeprazole
What doses of Orilissa are available?
Orilissa is available as 150mg and 200mg tablets.
How do I store Orilissa?
Store Orilissa tablets at room temperature, away from children.
Which pharmaceutical company manufactures Orilissa?
Orilissa is manufactured by AbbVie Corporation.
Is there a generic version of Orilissa?
No, Orilissa is only available as a brand-name product at this time.
How do I stop taking Orilissa?
Orilissa 200mg twice daily dosing should not be taken for more than 1 year unless directed by your doctor
Can Orilissa be used if I am pregnant?
Orilissa may cause pregnancy loss. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.
Can Orilissa be used if I am breast feeding?
It is unknown if Orilissa is excreted into breast milk since the use of Orilissa during breastfeeding has not been studied. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.
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What happens after I place my order for Orilissa with Universal Drugstore?
Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.
How long does it take to process and deliver my order for Orilissa?
Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.
Can I track my order of Orilissa?
Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.
What should I do if there is an issue with my order for Orilissa?
Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.
How is my medication packaged to ensure privacy and safety?
All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.
Does Universal Drugstore ship medications that require refrigeration or special handling?
Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.
What are the shipping costs, and does Universal Drugstore offer free delivery?
Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.
Does Universal Drugstore accept Medicare or Medicaid for prescriptions?
Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.
Can I use private health insurance to cover my prescription from Universal Drugstore?
Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.
How secure is my payment information when ordering from Universal Drugstore?
We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.
Can I order a generic alternative to Orilissa?
Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.
Do I need a prescription to order Orilissa?
If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.
Can I order multiple medications at once?
Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.
Can I refill my prescription through Universal Drugstore?
Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.
Does Universal Drugstore offer discounts or price matching?
Yes! We offer:
- Up to 80% savings on medications
- Price match guarantee – we’ll match competitor pricing on qualifying medications
- 10% off your first order for new customers
How can I contact Universal Drugstore for additional support?
We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.
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The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment.
Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.