Parnate

Parnate Drug Information

• Parnate Overview

  Tranylcypromine is an antidepressant (monoamine oxidase inhibitor). Parnate treats depression by restoring the balance of certain natural substances (neurotransmitters) in the brain. Tranylcypromine can improve your mood and feelings of well-being. Usually, Parnate is used in persons who have not responded to treatment with other drugs.

• Parnate Warnings

  Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Parnate may rarely cause an attack of extremely high blood pressure (hypertensive crisis), which may be fatal. Many drug interactions can increase this risk. Food and drinks that contain tyramine can also increase this risk. See also Side Effects and Drug Interactions sections. Check your blood pressure regularly. Tell your doctor and pharmacist about all prescription/nonprescription drugs and herbal products you take before starting tranylcypromine. Ask them before starting any other drugs while taking tranylcypromine, and even when you stop taking tranylcypromine since it can still cause these interactions for a period of time.

• How to Use Parnate

  Read the Medication Guide available from your pharmacist before you start using tranylcypromine and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take Parnate by mouth, usually in divided doses or as directed by your doctor. Parnate may be taken with or without food. Dosage of Parnate is based on your medical condition and response to therapy and usually will not be more than 60 milligrams per day. To reduce your risk of side effects, your doctor may start you at a low dose and gradually increase your dose. Once your condition improves and you are better for a while, your doctor may work with you to reduce your regular dose. Follow your doctor's instructions carefully. Do not take more or less medication or take it more frequently than prescribed. Your condition will not improve any faster and your risk of side effects will increase. Use Parnate regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. It may take several weeks for the full benefits of Parnate to be noticed. Do not stop taking Parnate without consulting your doctor. If you suddenly stop using Parnate, you may have withdrawal symptoms (such as restlessness, confusion, hallucinations, headache, weakness, and diarrhea). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used tranylcypromine for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal. Inform your doctor if your condition persists or worsens.

• Parnate Precautions

  Before taking tranylcypromine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Parnate may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Parnate, tell your doctor or pharmacist your medical history,a certain kind of adrenal gland tumor (pheochromocytoma), cerebrovascular disease (e.g., stroke), high blood pressure, heart problems (e.g., coronary artery disease, chest pain, heart attack, heart failure), severe/frequent headaches, mental/mood disorders (e.g., schizophrenia, bipolar disorder), liver problems, kidney disease, certain nervous system diseases (Parkinson's syndrome, seizures), overactive thyroid (hyperthyroidism), personal/family history of glaucoma (angle-closure type). Parnate may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Before having surgery or any procedures requiring use of contrast dye (e.g., myelography), tell your doctor or dentist you are on Parnate. You may need to stop taking Parnate beforehand. Follow your doctor's instructions carefully. If you have heart disease, Parnate may mask chest pain. Avoid strenuous exercise while taking Parnate. If you have diabetes, tranylcypromine may lower your blood sugar. Check your blood sugar regularly and share the results with your doctor. Tell your doctor right away if you have symptoms of low blood sugar such as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Caution is advised when using Parnate in the elderly because they may be more sensitive to the effects of the drug, especially the effects on blood pressure. Parnate should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Since untreated mental/mood problems (such as depression) can be a serious condition, do not stop taking Parnate unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using Parnate during pregnancy. Parnate passes into breast milk. Consult your doctor before breast-feeding.

• Parnate Misdose

  If you miss a dose of Parnate, take as soon as you remember unless the next scheduled dose is within 2 hours. In that case, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

• Parnate Interactions

  Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.other antidepressants (including maprotiline, mirtazapine, nefazodone, TCAs such as amitriptyline/nortriptyline), appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine, methylphenidate), apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, deutetrabenazine, dextromethorphan, certain drugs for high blood pressure (such as guanethidine, methyldopa, beta blockers such as atenolol, clonidine, rauwolfia alkaloids), other MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline), certain narcotic medications (such as fentanyl, methadone, tapentadol), certain drugs for Parkinson's (such as entacapone, levodopa, tolcapone), s-adenosyl-L-methionine (SAM-e), street drugs (such as LSD, mescaline), stimulants (such as amphetamines, cocaine, dopamine, epinephrine, phenylalanine), tetrabenazine, triptan migraine drugs (such as sumatriptan, rizatriptan), tramadol, tyrosine, tryptophan, valbenazine. The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/ "ecstasy," St. John's wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), meperidine, among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs. Tell your doctor or pharmacist if you are using any of these medications before, during, or within 2 weeks after treatment with tranylcypromine. Tell your doctor or pharmacist if you have taken fluoxetine during at least 5 weeks before starting tranylcypromine. Discuss with your doctor how much time to wait between starting or stopping any of these drugs and taking tranylcypromine. Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine). Check the labels on all your medicines (such as allergy, cough-and-cold products, diet pills) because they may contain dextromethorphan, decongestants, stimulants, or ingredients that cause drowsiness. Ask your pharmacist about the safe use of those products. It is very important that you follow special dietary restrictions in order to limit the amount of tyramine in your diet. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas) or eating large amounts of chocolate. Caffeine can increase the side effects of Parnate. Foods and beverages high in tyramine should be avoided while you are taking Parnate and for at least 2 weeks after you stop using Parnate.aged cheeses (cheddar, camembert, emmenthaler, brie, stilton blue, gruyere, gouda, brick, bleu, roquefort, boursault, parmesan, romano, provolone, liederdranz, colby, edam), aged/dried/fermented/salted/smoked/pickled/processed meats and fish (includes bacon, summer sausage, liverwurst, hot dogs, corned beef, pepperoni, salami, bologna, ham, mortadella, pickled or dried herring), banana peel, beef/chicken liver (stored, not fresh), bouillon cubes, commercial gravies, concentrated yeast extracts, fava beans, Italian green beans, broad beans, fermented bean curd, homemade yeast-leavened bread, kim chee (Korean fermented cabbage), orange pulp, overripe or spoiled fruits, packaged soups, red wine, sauerkraut, sherry, snow pea pods, sourdough bread, soy sauce, soybeans, soybean paste/miso, tofu, tap beer and ale, vermouth. Moderate-to-alcohol-free beer, avocados, bananas, bottled beer and ale, chocolate and products made with chocolate, coffee, cola, cultured dairy products (such as buttermilk, yogurt, sour cream), distilled spirits, eggplant, canned figs, fish roe (caviar), green bean pods, pate, peanuts, port wine, raisins, raspberries, red plums, spinach, tomatoes, white wine. Tell your doctor or pharmacist right away if you notice symptoms of high blood pressure such as fast/slow heartbeat, vomiting, sweating, headache, chest pain, sudden vision changes, weakness on one side of the body, or slurred speech. Contact your healthcare professionals (e.g., doctor, pharmacist, dietician) for more information, including recommendations for your diet.

• Parnate Side Effects

  What are Parnate side effects?

  Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Parnate may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Parnate as a result of an interaction with other medications.

  Side Effects of Parnate

  The side effects of Parnate may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Parnate. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Parnate may also occur as a result of an interaction with certain herbal supplements, foods or drinks.

  Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Parnate, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Parnate.

  By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Parnate, or any other medication, should contact their physician. General information about Parnate and the side effects associated with Parnate are described in the following:

  Common Parnate Side Effects

  Severe

  • myoclonus
  • orthostatic hypotension

  Less Severe

  • abnormal sexual function
  • blurred vision
  • drowsy
  • dizziness
  • insomnia
  • fatigue
  • general weakness
  • tremor
  • weight gain
  • headache disorder
  • hyperreflexia
  • nervousness
  • sedation
  • excitement

  Less Frequent Parnate Side Effects

  Severe

  • tachycardia

  Less Severe

  • disorder of ejaculation
  • symptoms of anxiety
  • agitation

  Rare or Very Rare Parnate Side Effects

  Severe

  • leukopenia
  • suicidal ideation
  • hepatitis
  • lupus-like syndrome
  • SIADH syndrome
  • hypertensive crisis
  • manic disorder
  • abnormal hepatic function tests
  • anemia
  • agranulocytosis
  • thrombocytopenic disorder
  • neutropenic disorder
  • secondary angle-closure glaucoma
  • suicidal
  • serotonin syndrome
  • hypotension
  • seizure disorder
  • scleroderma

  Less Severe

  • palpitations
  • xerostomia
  • constipation
  • hyperhidrosis
  • anorexia
  • erectile dysfunction
  • acute confusion
  • euphoria
  • nystagmus
  • paresthesia
  • nausea
  • vomiting
  • ataxia
  • edema
  • alopecia
  • increased urinary frequency
  • urinary retention
  • tinnitus
  • skin rash
  • acne vulgaris
  • pruritus of skin
  • urticaria
  • skin photosensitivity
  • chills
  • acute abdominal pain
  • lethargy
  • urinary incontinence

• Parnate Storage

  Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Parnate when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.