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Buy Silvadene Online
(Silver Sulfadiazine)

What is Silvadene?

What is Silvadene?

Silvadene (silver sulfadiazine) is a topical cream used to prevent and treat skin infections in burn wounds. It’s commonly applied to second and third-degree burns to stop bacterial growth and protect the skin while it heals. This antibacterial medication belongs to a class of drugs called sulfonamides (often known as sulfa drugs).

Silvadene should not be used on premature or newborn infants under two months of age due to the risk of serious side effects.

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Purchase Silvadene from Universal Drugstore today and save!

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Silvadene brand

Silvadene 
1%

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Prescription Required
Product of United Kingdom

Product of United Kingdom

Marketed as Flamazine in United Kingdom.

Also available from Canada
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Product of Canada

Product of Canada

Marketed as Flamazine in Canada

Silvadene (generic Silvadene)

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Silver Sulfadiazine 
1%

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Prescription Required
Product of Turkey

Product of Turkey

Marketed as Silvamed in Turkey.

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Important information about Silvadene

The active ingredient in Silvadene is silver sulfadiazine. It works by combining the antibacterial effects of silver and the antibiotic properties of sulfadiazine. The silver ions disrupt bacterial cell walls and interfere with enzymes that bacteria need to survive, while the sulfadiazine component stops bacteria from producing folic acid, which they require to grow.

Together, these actions prevent the spread of infection in burn wounds and promote cleaner, safer healing. Silvadene has broad antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as some yeast species that can infect damaged skin.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Silvadene. However, the following is a synopsis of the general guidelines for the use of Silvadene:

  • Wash your hands before and after applying the cream.
  • Gently clean and dry the burned area as directed by your healthcare provider.
  • Using a sterile glove or applicator, apply a thin, even layer (about 1/16 inch thick) of Silvadene cream to the entire affected area.
  • Reapply the cream as often as needed to keep the area covered, usually once or twice daily.
  • If dressings are used, make sure they are changed regularly to prevent contamination.
  • Continue using Silvadene until the wound has healed or until your healthcare provider advises you to stop.

Some mild or common side effects of Silvadene include:

  • Itching or mild burning at the application site.
  • Temporary skin discoloration.
  • Rash or redness (erythema).

Some individuals may experience serious side effects while using Silvadene. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Signs of allergic reactions such as hives, blistering, or skin rash.
  • Stevens-Johnson syndrome or toxic epidermal necrolysis (rare but serious skin reactions).
  • Unusual tiredness, weakness, or signs of anemia.
  • Decrease in white blood cells (leukopenia).
  • Yellowing of the skin or eyes (possible sign of liver issues).
  • Severe stomach pain or signs of kidney problems (such as interstitial nephritis).

These are not all of the possible side effects of Silvadene. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Silvadene, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

  • An allergy to sulfa drugs or silver sulfadiazine.
  • A history of severe allergic skin reactions such as Stevens-Johnson syndrome or erythema multiforme.
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • Kidney or liver disease.
  • Blood disorders, including anemia or leukopenia.
  • Large burn wounds or extensive skin damage.
  • Pregnant or breastfeeding.

Silvadene should not be used in individuals who:

  • Have a known allergy or hypersensitivity to silver sulfadiazine, sulfonamides, or any component of the cream.
  • Are less than two months of age.
  • Are pregnant and near their due date.

Silvadene typically begins working soon after application by reducing bacterial growth in the wound. However, visible signs of improvement may take several days, depending on the depth and severity of the burn. Full healing depends on many factors, including the size of the affected area, general health, and how well the wound is cared for. Always follow your doctor’s guidance on treatment duration.

When Silvadene is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Other topical creams or ointments are applied to the same area.
  • Oral sulfonamide medications.
  • Enzyme-inducing drugs such as phenytoin.
  • Blood-thinning medications (anticoagulants).
  • Supplements or herbal remedies are used for wound healing.

Silvadene is available in the following dosage forms and strengths: 1% silver sulfadiazine cream. Your dose and frequency will be determined by your healthcare provider.

If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next scheduled application, skip the missed dose and continue your regular schedule. Do not apply extra cream to make up for a missed application.

Store Silvadene cream at room temperature and keep it tightly closed and out of direct sunlight or excessive heat. Do not freeze the cream. Always keep it out of reach of children and pets.

Silvadene is manufactured by Pfizer Inc.

Yes, there are generic versions of Silvadene available. Other brand names of silver sulfadiazine topical include SSD and Thermazene.

Do not stop using Silvadene without consulting your healthcare provider. If your wound has healed or if your doctor recommends discontinuing treatment, gently clean the area and stop applying the cream. If you experience allergic reactions, skin irritation, or any unusual symptoms, stop using the cream and seek medical attention right away.

Silver sulfadiazine is generally avoided near term (late pregnancy) because sulfonamides can affect the baby’s red blood cells. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will determine if the potential benefits of using Silvadene outweigh the risks.

Talk to your doctor if you are breastfeeding or planning to breastfeed. Small amounts of the drug may pass into breast milk, and sulfonamides can affect infants younger than two months. Your healthcare provider will decide whether to continue or adjust your treatment.

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Important information about buying Silvadene from UniversalDrugstore™

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

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Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Yes! We offer:

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The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.