Starlix

(Nateglinide)

The active ingredient in Starlix is nateglinide. Starlix works by lowering blood sugar levels by stimulating beta cells in the pancreas to release insulin. Because it works rapidly and for a short duration, it is taken before meals to target post-meal glucose spikes.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Starlix. However, the following is a synopsis of the general guidelines for the use of Starlix:

• Starlix is taken by mouth.
• It should be taken 1 to 30 minutes before each main meal.
• If you skip meals, you should skip the scheduled dose of Starlix for that meal.
• If you add an extra meal, you may need an extra dose as directed by your healthcare provider.
• It may be used as monotherapy or in combination with other medications like metformin.
• Follow your prescribed diet and exercise plan while taking this medication.
• Regular blood glucose testing is important to monitor treatment effectiveness.

Some mild or common side effects of Starlix include:

• Hypoglycemia (low blood sugar).
• Back pain.
• Joint pain.
• Dizziness.
• Headache.
• Cold-like symptoms.
• Runny or stuffy nose.

Some individuals may experience serious side effects while using Starlix. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Severe hypoglycemia with confusion, fainting, seizures, or loss of consciousness.
• Allergic reactions such as hives, skin rash, swelling of the face, lips, or throat, or trouble breathing.
• Signs of liver problems include dark urine, yellowing of the skin or eyes, or persistent nausea.

These are not all of the possible side effects of nateglinide. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Starlix, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

• Type 1 diabetes.
• Diabetic ketoacidosis.
• Liver disease.
• A history of hypoglycemia.
• Kidney problems.
• Thyroid disorders.
• Neuropathy.
• A history of allergic reactions to diabetes medicines.
• Irregular eating patterns or frequently skipped meals.
• Pregnancy or plans to become pregnant.
• Breastfeeding or plans to breastfeed.

Starlix is contraindicated in patients with type 1 diabetes mellitus or diabetic ketoacidosis. It should not be used in patients with known hypersensitivity to nateglinide or any component of the formulation.

Starlix begins lowering blood glucose levels shortly after it is taken, especially after meals. Its effect is rapid and short-acting, which is why it is taken before meals. Long-term improvements in HbA1c levels are usually seen over several months of consistent use.

When Starlix is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Beta-blockers such as propranolol, which may mask symptoms of hypoglycemia.
• Corticosteroids such as prednisone, which may increase blood glucose levels.
• Thiazide diuretics such as hydrochlorothiazide, which may reduce blood sugar control.
• Other antidiabetic agents, including sulfonylureas or insulin, may increase the risk of hypoglycemia.
• Drinking alcohol, which can increase the risk of low blood sugar.
• St. John’s wort, which may affect blood glucose control.

Starlix is available as oral tablets in the following strengths:

• 60 mg tablets.
• 120 mg tablets.

Typical dosing based on prescribing information:

The usual starting dose is 120 mg taken three times daily before meals. Some patients, especially those closer to blood glucose goals, may start at 60 mg three times daily.

Dose adjustments may be made based on blood glucose response and tolerance.

It should be stored at room temperature, away from the reach of children or pets.

Starlix was originally manufactured by Novartis Pharmaceuticals.

Yes, Starlix is available as a generic medication under the name nateglinide.

Do not stop taking Starlix without first speaking to your healthcare provider. Stopping treatment suddenly may lead to uncontrolled high blood sugar (hyperglycemia). Your provider will guide any dose changes or discontinuation.

Starlix is not routinely recommended during pregnancy. If you are pregnant or planning to become pregnant, talk to your healthcare provider. They may recommend insulin or another treatment with better-established safety during pregnancy.

It is not known whether nateglinide passes into breast milk. Because of the potential risk of hypoglycemia in a nursing infant, breastfeeding is generally not recommended while taking Starlix. Discuss alternative feeding options or medications with your healthcare provider.