What Is the Main Difference Between Trokendi XR and Topamax?
Trokendi XR and Topamax are not the same medication, but they both contain the s...
Topamax (topiramate) is a brand-name anticonvulsant that is used to treat certain types of seizures including partial-onset seizures, primary generalized tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome in adults and children 2 years and older.
Topamax is also used to prevent migraine headaches in adults and children 12 years of age and older. This medicine will only prevent migraine headaches or reduce the number of attacks. It will not treat a headache that has already begun.
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Marketed as Topamac in India.
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Sourced from Canada
Marketed as Mylan-Topiramate in Canada.
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Marketed as Mylan-Topiramate in Canada.
Sourced from Canada
Marketed as Mylan-Topiramate in Canada.
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The active ingredient in Topamax is topiramate, an antiepileptic drug. It works by blocking your brain from sending signals and chemicals that can cause seizures by overexciting your nerves, which will then help the bursts of activity in the brain. In terms of migraine prevention, it is not exactly known how it works.
Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Topamax. However, the following is a synopsis of the general guidelines for the use of Topamax:
The most common side effects of Topamax seen in clinical trials include:
Some individuals may experience serious side effects while using Topamax. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:
These are not all of the possible side effects of Topamax. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.
Before starting Topamax, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:
Inform your doctor if you are experiencing diarrhea or if you have a history of:
There are no obvious contraindications with Topamax. However, let your healthcare provider know if you are allergic to topiramate or have had any allergic reactions to other seizure medications.
For epilepsy, it may take 2 to 4 weeks for Topamax to reach its full effectiveness. For migraines, it can take about 1 month to notice a reduction in the frequency of migraine attacks, but 2 to 3 months for Topamax to work fully in managing migraines.
When Topamax is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:
Seizures (when used alone)
Topamax, Eprontia solution, generic immediate-release tablet, and generic sprinkle capsule
Adults and children (age 10 years or older): The usual starting dose is 25 mg taken orally once or twice daily. The typical maintenance dose is 200 mg taken twice daily.
Children (age 2 to 9 years old): The usual starting dose is 25 mg taken orally at night. Based on body weight, the typical maintenance dose ranges from 75 mg to 200 mg taken twice daily.
Qudexy XR, Trokendi XR, and generic extended-release capsule
Adults and children (age 10 years or older): The usual starting dose is 50 mg taken orally once daily. The typical maintenance dose is 400 mg daily.
Children (age 2 to 9 years old): The usual starting dose is 25 mg taken orally at night. Based on body weight, the typical maintenance dose ranges from 150 mg to 400 mg daily.
Note: Trokendi XR is only approved for children aged 6 to 9 years old when used alone for seizures.
Seizures (when combined with other medications)
Topamax, Eprontia solution, generic immediate-release tablet, and generic sprinkle capsule
Adults and adolescents (age 17 or older): The usual starting dose is 25 mg to 50 mg taken orally once daily. The typical maintenance dose ranges from 200 mg to 400 mg daily, divided into two doses throughout the day.
Children (age 2 to 16 years old): The usual starting dose is 25 mg taken orally at night. Based on body weight, the typical maintenance dose ranges from 5 mg/kg to 9 mg/kg daily, divided into two doses throughout the day. The maximum daily dose is 400 mg.
Qudexy XR, Trokendi XR, and generic extended-release capsule
Adults (age 17 or older): The usual starting dose is 25 mg to 50 mg taken orally once daily. The typical maintenance dose ranges from 200 mg to 400 mg daily, with a maximum daily dose of 400 mg.
Children (age 2 to 16 years old): The usual starting dose is 25 mg taken orally at night. The typical maintenance dose is 5 mg/kg to 9 mg/kg daily, with a maximum daily dose of 400 mg.
Note: Trokendi XR is only approved for children aged 6 to 16 years old when used with other seizure medications.
Migraine
Topamax, Eprontia solution, generic immediate-release tablet, and generic sprinkle capsule
Adults and children (age 12 or older): The usual starting dose is 25 mg taken orally at night. The typical maintenance dose is 50 mg taken twice daily.
Qudexy XR, Trokendi XR, and generic extended-release capsule
Adults and children (age 12 or older): The usual starting dose is 25 mg taken orally once daily. The typical maintenance dose is 100 mg taken once daily.
For a missed dose, take the medicine as soon as you can. Do not take two doses at one time and skip a missed Topamax dose if your next dose is due in less than 6 hours. Call your doctor if you have missed more than one dose.
Store at room temperature, away from light, moisture, and heat. Keep out of reach of children too.
Janssen Pharmaceuticals, Inc. is the company that manufactures Topamax.
There are several lower-cost generics of Topamax available with the active ingredient of topiramate.
If you wish to discontinue Topamax, consult your healthcare provider. Stopping Topamax abruptly can increase the risk of seizures. Your provider can guide you in safely discontinuing the medication by gradually reducing your dosage over time.
Avoid taking Topamax if you are pregnant, as it may lead to significant birth defects or hinder the growth of your unborn baby. If you are planning to become pregnant, consult your healthcare provider to explore safer treatment options. If you discover you are pregnant while using this medication, contact your provider immediately to discuss the potential risks and benefits of continuing treatment.
Consult your healthcare provider to weigh the benefits and risks of using Topamax while breastfeeding. Although there have not been clinical studies on nursing mothers and their infants, it is known to pass into breast milk. Some reports have noted diarrhea and drowsiness in breastfed babies whose mothers were taking Topamax.
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Trokendi XR and Topamax are not the same medication, but they both contain the s...
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Jamie Winn, PharmD, is a licensed pharmacist and seasoned medical content reviewer with over 20 years of experience in clinical pharmacy, patient care, and healthcare leadership.
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Shirley is a Medical Writer and first-year Doctor of Pharmacy (PharmD) student at the University of Alberta, where she is building on her strong foundation in health sciences and patient care.
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