Treximetand/or alternativesChemical Ingredient: Sumatriptan Succinate/Naproxen Sodium
What is a generic medication?
Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.
No generic is available for Treximet 85/500mg.
- Manufactured by Glaxo Smithkline
- Product of United States • Shipped from United States
- Prescription Required
No generic is available for Treximet 85/500mg.
This product is currently unavailable
Treximet Drug Information
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Treximet Drug Information
naproxen and sumatriptan. It helps to relieve headache, pain, and other migraine symptoms (including nausea, vomiting, sensitivity to light/sound) in adults and in children 12 years or older. Prompt treatment helps you return to your normal routine and may decrease your need for other pain medications. Naproxen is known as a nonsteroidal anti-inflammatory drug (NSAID). Treximet is used to relieve pain. Sumatriptan belongs to a class of drugs called triptans. It affects a certain natural substance (serotonin) that causes narrowing of blood vessels in the brain. It may also relieve pain by affecting certain nerves in the brain. Treximet does not prevent future migraines or lessen how often you get migraine attacks.
See also Side Effects and Precautions sections. Nonsteroidal anti-inflammatory drugs (including naproxen) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking Treximet but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take Treximet right before or after heart bypass surgery (CABG). Treximet may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning at any time while taking Treximet. Older adults may be at higher risk for this effect.black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, slurred speech, sudden vision changes.
How to Use Treximet
Read the Medication Guide provided by your pharmacist before you start using Treximet and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take Treximet by mouth at the first sign of a migraine as directed by your doctor, with a full glass of water (8 ounces/240 milliliters). Do not lie down for at least 10 minutes after taking Treximet. To prevent stomach upset, take Treximet with food, milk, or an antacid. Do not break, crush, or chew the tablet. The Dosage of Treximet is based on your medical condition, age, and response to treatment. If there is no improvement in your symptoms, do not take more doses of Treximet before talking to your doctor. If your symptoms are only partly relieved, or if your headache comes back, you may take another dose at least two hours after the first dose. Do not take more than 2 doses in a 24-hour period. If you have a higher risk for heart problems (see Precautions), your doctor may perform a heart exam before you start taking Treximet. He/she may also direct you to take your first dose of Treximet in the office/clinic to monitor for serious side effects (such as chest pain). Talk to your doctor for details. If you are using drugs for migraine attacks on 10 or more days each month, the drugs may actually make your headaches worse (medication overuse headache). Do not use medications more often or for longer than directed. Tell your doctor if you need to use Treximet more often, or if the medication is not working as well, or if your headaches get worse.
Before taking Treximet, tell your doctor or pharmacist if you are allergic to naproxen or to sumatriptan; or to aspirin or other NSAIDs (such as ibuprofen, celecoxib); or if you have any other allergies. Treximet may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before taking Treximet, tell your doctor or pharmacist your medical history,asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), blood circulation problems (for example, in your legs, arms/hands, or stomach), blood disorders (such as anemia, bleeding/clotting problems), growths in the nose (nasal polyps), certain types of headaches (hemiplegic or basilar migraine), heart problems (such as chest pain, irregular heartbeat, previous heart attack), liver disease, seizure, stroke or "mini-stroke" (transient ischemic attack), throat/stomach/intestinal problems (such as bleeding, heartburn, ulcers), swelling (edema, fluid retention). Certain conditions can increase your risk for heart problems. Tell your doctor if you have any of these conditions,high blood pressure, high cholesterol, diabetes, family history of heart disease, overweight, smoker, postmenopausal (women), age more than 40 years (men). Kidney problems can sometimes occur with the use of NSAID medications, including naproxen. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine. Treximet may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis). This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information. Treximet contains salt (sodium). Before using Treximet, tell your doctor if you are limiting the amount of salt in your diet. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Treximet may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness. The risk of heart disease, kidney/liver disease, and high blood pressure increases with age. Older adults may be more sensitive to the side effects of Treximet, especially stomach/intestinal bleeding, increased blood pressure, kidney problems, and heart problems. Before using Treximet, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, Treximet should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery. These drugs pass into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
Not applicable. (See How to Use section.)
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (such as prednisone), "water pills" (diuretics such as furosemide). Taking MAO inhibitors with Treximet may cause a serious (possibly fatal) drug interaction. Do not take any MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with Treximet. Most MAO inhibitors should also not be taken for two weeks before treatment with Treximet. Ask your doctor when to start or stop taking Treximet. The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs. Treximet may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others. Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as celecoxib, ibuprofen, ketorolac). These drugs are similar to the naproxen in Treximet and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Daily use of naproxen may decrease aspirin's ability to prevent heart attack/stroke. Talk to your doctor about using a different medication (such as acetaminophen) to treat pain/fever. If you must take naproxen, talk to your doctor about possibly taking immediate-release aspirin (not enteric-coated/EC) and then taking your naproxen at a different time after your aspirin. Do not increase your daily dose of aspirin or change the way you take aspirin/other medications without your doctor's approval. If you also take any ergotamine medication (such as dihydroergotamine) or other "triptan" drugs (such as zolmitriptan, rizatriptan), you will need to separate your dose of Treximet from your dose of these other medications to lessen the chance of serious side effects. Ask your doctor how long you should wait between your doses of these drugs. Treximet may interfere with certain laboratory tests (including bleeding times, adrenal function tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Treximet.
Treximet Side Effects
Flushing, feelings of tingling/numbness/prickling/heat, nausea, upset stomach, tiredness, weakness, drowsiness, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed Treximet because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Treximet do not have serious side effects. Treximet may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Tell your doctor right away if you have any serious side effects,blue fingers/toes/nails, cold hands/feet, difficult/painful swallowing, easy bleeding/bruising, hearing changes (such as ringing in the ears), mental/mood changes, signs of kidney problems (such as change in the amount of urine), unexplained stiff neck, symptoms of heart failure (such as swelling ankles/feet, unusual tiredness, unusual/sudden weight gain). Sumatriptan can commonly cause chest/jaw/neck tightness, pain, or pressure that is usually not serious. However, these side effects are like symptoms of a heart attack, which may include chest/jaw/left arm pain, shortness of breath, or unusual sweating. Get medical help right away if these or other serious side effects occur,fast/irregular heartbeat, fainting, severe stomach/abdominal pain, bloody diarrhea, seizure, signs of a stroke (such as weakness on one side of the body, trouble speaking, sudden vision changes, confusion). Treximet may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage,dark urine, persistent nausea/vomiting/loss of appetite, yellowing eyes/skin. Treximet may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section).fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness. A very serious allergic reaction to Treximet is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.List of Treximet side effects
Store in the original container at room temperature away from light and moisture. To help protect from moisture, keep the desiccant in the container. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Treximet when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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