Trulance
Trulance is a medication used in adults to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). Trulance belongs to a class of drugs called guanylate cyclase-C agonists. It is typically taken once daily by mouth.
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Trulance Prescription Required
Plecanatide Prescription Required
Marketed as Plectide in India
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Important information about Trulance
How does Trulance work?
The active ingredient in Trulance is plecanatide. The mechanism of action of plecanatide is that it acts as a laxative. Plecanatide is structurally similar to human uroguanylin, and both are guanylate cyclase-C (GC-C) agonists. Plecanatide binds to GC-C, resulting in an increase in chloride and bicarbonate in the intestines. This causes fluid secretion in the intestines, thus softening the stool and speeding up the movement of food through your GI tract. This helps manage chronic constipation and increases the number of bowel movements.
How do you use Trulance?
Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Trulance. However, the following is a synopsis of the general guidelines for the use of Trulance:
- Trulance is taken once daily, with or without food.
- If you forget to take a dose, skip the missed dose and take the next dose at the regular time.
- Swallow the tablet whole.
If you have swallowing problems, the tablets can be crushed and mixed in applesauce or water. To take Trulance in applesauce, crush the tablet until it is a powder. Mix the powder with 1 teaspoon of applesauce. When fully combined, swallow the entire powder and applesauce mixture immediately. To take Trulance in water, put the tablet in a cup and pour 30 ml of room-temperature water into the cup. Mix the mixture for at least 10 seconds, and then swallow the mixture right away. If part of the tablet is still left, add another 30 ml of water, mix, and swallow. For both the applesauce and water, do not store the mixtures for future use.
Trulance can be administered via a nasogastric or gastric feeding tube with water. Contact your healthcare provider for instructions on how to crush and safely administer Trulance tablets.
What are the side effects of Trulance?
The most common side effects of Trulance seen in clinical trials as compared to placebo include:
- Diarrhea.
- Sinus infection.
- Upper respiratory tract infection.
- Stomach pain or discomfort.
- Bloating.
- Gas.
- Nausea.
- Urinary tract infection.
Some individuals may experience serious side effects while using Trulance. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:
- Severe diarrhea.
- Allergic reactions.
These are not all of the possible side effects of Trulance. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.
What are the warnings or precautions for Trulance?
Before starting Trulance, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you are:
- Pregnant or planning to become pregnant.
- Breastfeeding or planning to breastfeed.
- Boxed Warning
There is a risk of serious dehydration in pediatric patients with the use of Trulance. Be aware that Trulance is contraindicated in patients less than 6 years of age, and avoid using Trulance in patients less than 18 years of age. In nonclinical studies of young juvenile mice, administration of a single dose of plecanatide resulted in death due to dehydration. The safety and efficacy of Trulance in patients less than 18 years haveage has not yet been established.
Are there any contraindications with Trulance?
- Known or suspected GI blockage
- Patients less than 6 years of age due to the risk of serious dehydration
How long does it take Trulance to work?
Trulance takes up to 24 hours to start working. In some patients, it may take one week for the full effects.
What interacts with Trulance?
When Trulance is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:
- Idelalisib. It may increase the risk of severe diarrhea.
What doses of Trulance are available?
Trulance (plecanatide) is available in the following dosage form and strength: 3 mg tablets.
How do I store Trulance?
Store Trulance at room temperature, away from light and moisture. Keep out of reach of children.
Which pharmaceutical company manufactures Trulance?
Bausch Health manufactures Trulance.
Is there a generic version of Trulance?
Trulance is the brand name of plecanatide. There are currently no generic versions of Trulance available.
How do I stop taking Trulance?
Do not stop taking Trulance without talking to your healthcare provider. Your constipation may return if you stop taking it.
Can Trulance be used if I am pregnant?
According to the manufacturer, the use of Trulance is unlikely to result in fetal exposure. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.
Can Trulance be used if I am breast feeding?
Trulance is unlikely to be present in breast milk. However, according to the manufacturer, the benefits of breastfeeding, the benefits of Trulance, and the risks of Trulance to the infant should all be considered. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.
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What happens after I place my order for Trulance with Universal Drugstore?
Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.
How long does it take to process and deliver my order for Trulance?
Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.
Can I track my order of Trulance?
Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.
What should I do if there is an issue with my order for Trulance?
Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.
How is my medication packaged to ensure privacy and safety?
All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.
Does Universal Drugstore ship medications that require refrigeration or special handling?
Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.
What are the shipping costs, and does Universal Drugstore offer free delivery?
Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.
Does Universal Drugstore accept Medicare or Medicaid for prescriptions?
Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.
Can I use private health insurance to cover my prescription from Universal Drugstore?
Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Unievrsal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.
How secure is my payment information when ordering from Universal Drugstore?
We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.
Can I order a generic alternative to Trulance?
Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.
Do I need a prescription to order Trulance?
If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription.
Can I order multiple medications at once?
Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.
Can I refill my prescription through Universal Drugstore?
Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.
Does Universal Drugstore offer discounts or price matching?
Yes! We offer:
- Up to 80% savings on medications
- Price match guarantee – we’ll match competitor pricing on qualifying medications
- 10% off your first order for new customers
How can I contact Universal Drugstore for additional support?
We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.
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