Veozah

The active ingredient in Veozah is fezolinetant. Fezolinentant belongs to a class of medications known as neurokinin 3 (NK3) receptor antagonists. These medications block a chemical known as neurokinin B (NKB) from acting on the part of the brain involved in regulating body temperature. Because of the way it works, Veozah does not generally have an effect on sex hormone levels in the body (like estrogen or progesterone), which often change during menopause.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Veozah. However, the following is a synopsis of the general guidelines for the use of Veozah:

• Veozah should be used exactly as prescribed by your healthcare provider.
• It is typically taken at the same time once a day with or without food.
• Veozah tablets should be taken whole. Do not cut, split, or chew the tablet.
• If you miss a dose, take it as soon as you remember with at least 12 hours remaining before your next dose. Continue with your regular schedule the following day. Do not take double doses to make up for a missed dose.

The most common side effects of Veozah seen in clinical trials as compared to placebo include:

• Stomach upset
• Diarrhea
• Insomnia
• Back pain
• Hot flush

Some individuals may experience serious side effects while using Veozah. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Symptoms of liver problems such as feeling more tired than usual, decreased appetite, nausea, vomiting, itching, yellowing of the skin or eyes, or pale feces
• Signs of an allergic reaction, including swelling of the face, lips, tongue, or throat, hives, and difficulty breathing

These are not all of the possible side effects of Veozah. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Veozah, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Liver disease
• Kidney problems

Boxed Warning

• Use of Veozah may cause hepatotoxicity or liver injury. Liver function blood tests should be evaluated before use and followed up on regularly during the course of treatment to monitor for abnormal values and adverse liver effects. If at any point there are symptoms of liver injury such as decreased appetite, fatigue, nausea, vomiting, itchiness, yellowing of the skin or eyes, pale feces, dark urine, or abdominal pain, immediately discontinue use and seek medical attention.

Do not use Veozah if you have:

• Cirrhosis
• Severe kidney problems or end-stage kidney disease
• Are taking a medication that is a CYP1A2 inhibitor

Veozah will start to work right after the first dose. However, it may take several weeks of consistent use to see the full benefit of Veozah.

When Veozah is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions.

Veozah is available in 45 mg tablets.

Veozah should be stored at room temperature, away from light and moisture, and out of reach of children.

Veozah is manufactured by the pharmaceutical company Astellas Pharma.

No, Veozah does not have a generic available yet.

Consult your doctor or pharmacist before starting, stopping, or changing medications while taking Veozah.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is not known if Veozah passes into breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.