Xiidra

The active ingredient in Xiidra is lifitegrast. Lifitegrast is a lymphocyte function-associated antigen-1 (LFA-1) blocker. It is unknown how exactly lifitegrast provides relief of dry eye symptoms, but it is thought that its anti-inflammatory effects may help with symptoms of eye dryness.

Other prescription medications for DED include Restasis (cyclosporine) eye drops. Although these also effectively manage symptoms of DED, they take a lot longer than Xiidra to see initial benefits.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Xiidra. However, the following is a synopsis of the general guidelines for the use of Xiidra:

• Typically Xiidra is used twice daily. Make sure to wash your hands before use. Instill one drop in each eye roughly 12 hours apart. Discard the remainder. Do not save the lifitegrast ophthalmic solution for next time.
• Once foil pouches are opened, Xiidra must be used immediately.
• Use exactly as prescribed. Do not exceed the recommended dose or duration of use.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

The most common side effects of Xiidra seen in clinical trials as compared to placebo include:

• Eye irritation
• Eye discomfort
• Blurred vision
• Unusual taste sensation known as dysgeusia
• Sinusitis

Some individuals may experience serious side effects while using Xiidra. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of an allergic reaction such as difficulty breathing, hives, rash, or swelling of the face or eyes

These are not all of the possible side effects of Xiidra. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Xiidra, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Are using other eyedrops
• Wear contact lenses
• Are pregnant or plan to become pregnant
• Are breastfeeding or plan to breastfeed

Do not use Xiidra if you have:

• An allergy to lifitegrast or any of the inactive ingredients in the product

Xiidra does not work right away. It can take a few weeks of regular use to see the benefit.

When Xiidra is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions.

Xiidra eye drops are available as a 5% ophthalmic solution.

Xiidra should be stored at room temperature away from light and out of the reach of children. Keep Xiidra single-use containers in their foil pouches until ready to use.

Xiidra is manufactured by the pharmaceutical company Bausch & Lomb.

Currently, there is no generic available for the brand name Xiidra.

Consult your doctor or pharmacist before starting, stopping, or changing medications while taking Xiidra.

It is unknown if Xiidra can cause harm to the unborn child. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is unknown if Xiidra passes into the breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.