Zestril

(Lisinopril)

Zestril (lisinopril) is a medication used to manage hypertension (high blood pressure) and heart failure, while also reducing the risk of death after a myocardial infarction (heart attack). Zestril belongs to the class of drugs called angiotensin-converting enzyme inhibitors (ACE inhibitors). It is important to take Zestril regularly, even if you feel well, because Zestril works to control your disease but does not cure your disease.

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Brand Versions

Zestril Prescription Required

Strength
5mg
Country
Canada
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Also available from United Kingdom and Australia
Strength
5mg
Country
United Kingdom
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Strength
5mg
Country
Australia
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Zestril Prescription Required

Strength
10mg
Country
Australia
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Also available from United Kingdom and Canada
Strength
10mg
Country
United Kingdom
Select Quantity
Strength
10mg
Country
Canada
Select Quantity
Please note that this item is currently on backorder and may require additional delivery time.

Zestril Prescription Required

Strength
20mg
Country
Australia
Select Quantity
Also available from United Kingdom and Canada
Strength
20mg
Country
United Kingdom
Select Quantity
Strength
20mg
Country
Canada
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Generic Versions
What are generics?

Lisinopril Prescription Required

Strength
2.5mg
Country
United States
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Lisinopril Prescription Required

Strength
5mg
Country
United States
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Lisinopril Prescription Required

Strength
10mg
Country
United States
Select Quantity

Lisinopril Prescription Required

Strength
20mg
Country
United States
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Lisinopril Prescription Required

Strength
30mg
Country
United States
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Lisinopril Prescription Required

Strength
40mg
Country
United States
Select Quantity

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Important information about Zestril

How does Zestril work?

The active ingredient in Zestril is lisinopril. Lisinopril works by dilating your blood vessels. This results in a decrease in your blood pressure and makes it easier for your heart to pump blood throughout your body. The effects of lisinopril result in lower blood pressure and less stress on your heart.

How do you use Zestril?

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Zestril. However, the following is a synopsis of the general guidelines for the use of Zestril:

  • Swallow the oral tablet with a drink of water. It is best to take it at the same time every day.
  • You can take Zestril with or without food.
  • The recommended starting dose of Zestril will depend on why you are taking it. For hypertension, the recommended starting dose is 10 mg once daily.
  • Do not stop taking Zestril even if you are feeling better unless your healthcare provider tells you to.
  • If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

What are the side effects of Zestril?

The most common side effects of Zestril include:

  • Lightheadedness.
  • Low blood pressure.
  • Cough.
  • Running nose.
  • Stomach pain.
  • Diarrhea.
  • Nausea.
  • Chest pain.

Some individuals may experience serious side effects while using Zestril. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Severe low blood pressure.
  • Decreased platelets. Symptoms include bruising, bleeding, and fatigue.
  • Decreased white blood cells. Symptoms include fever, aches, pain, infections, and flu-like symptoms.
  • Serious skin reactions like Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. This is any combination of itchy skin, rash, blistering of the skin, lips, eyes, and mouth with fever, chills, and headache.
  • Increased risk of an electrolyte imbalance, such as high potassium levels (hyperkalemia). This can lead to irregular heartbeats and muscle weakness.
  • Serious and life-threatening allergic reaction.
  • Kidney problems. Symptoms include a change in the frequency of urination.
  • Liver and pancreas disorders. Symptoms include jaundice (yellowing of the skin or eyes), dark urine, and abdominal pain.

These are not all of the possible side effects of Zestril. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

What are the warnings or precautions for Zestril?

Before starting Zestril, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you have:

  • Previous allergic reactions to blood pressure medications. This includes a history of angioedema.
  • Heart problems, such as a heart attack, heart disease, or heart failure.
  • Diabetes.
  • Liver problems.
  • Kidney disease, dialysis, and stenosis of the renal arteries.
  • Currently taking:
  • A medicine that contains an aliskiren.
  • An angiotensin receptor blocker (ARB).
  • A salt substitute that contains potassium, potassium supplements, or a potassium-sparing diuretic like spironolactone.
  • Temsirolimus and everolimus.
  • Sirolimus.

Boxed Warning

Zestril should not be used during pregnancy. If you are taking Zestril and discover you are pregnant, contact your healthcare provider and stop taking Zestril.

Are there any contraindications with Zestril?

  • Less than 6 years of age.
  • Previous allergic reaction (angioedema) with itching, hives, and swelling of the hands, feet, face, lips, or sudden difficulty breathing to any lisinopril or other ACE inhibitors.
  • Currently taking Entresto (sacubitril/valsartan). This increases your risk of angioedema.
  • Pregnant or planning to be pregnant.
  • Currently taking a blood pressure medication containing aliskiren and have diabetes or severe kidney impairment.

How long does it take Zestril to work?

It usually takes one hour for Zestril to start working and lower your blood pressure.

What interacts with Zestril?

When Zestril is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Medications that increase serum potassium levels.
  • Allopurinol.
  • Diabetic medications such as insulin and sulfonylureas.
  • Tissue plasminogen activator.
  • Temsirolimus and everolimus.
  • Sirolimus.
  • Lithium.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen.
  • Blood pressure drugs such as diuretics (“water pills”), angiotensin II receptor blockers (ARBs), and other ACE inhibitors.

What doses of Zestril are available?

Zestril is available in the following dosage forms and strengths: 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, and 40 mg tablets.

How do I store Zestril?

Store Zestril at room temperature, away from light and moisture. Keep out of reach of children.

Which pharmaceutical company manufactures Zestril?

Searchlight Pharma Inc. manufactures Zestril.

Is there a generic version of Zestril?

Lisinopril is the generic version.

How do I stop taking Zestril?

Do not stop taking Zestril without consulting your healthcare professional first. Your blood pressure may increase if you suddenly stop taking it.

Can Zestril be used if I am pregnant?

ACE inhibitors like Zestril are contraindicated during pregnancy. This is because ACE inhibitors can cause fetal and neonatal mortality. The use of ACE inhibitors in pregnancy has also been associated with cardiac malformations, neurological malformations, and neonatal hypotension. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Can Zestril be used if I am breast feeding?

ACE inhibitors like Zestril are contraindicated in breastfeeding. Studies have reported the presence of ACE inhibitors in breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.

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Important information about buying Zestril from UniversalDrugstore™

What happens after I place my order for Zestril with Universal Drugstore?

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

How long does it take to process and deliver my order for Zestril?

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Can I track my order of Zestril?

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

What should I do if there is an issue with my order for Zestril?

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

How is my medication packaged to ensure privacy and safety?

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Does Universal Drugstore ship medications that require refrigeration or special handling?

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

What are the shipping costs, and does Universal Drugstore offer free delivery?

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Does Universal Drugstore accept Medicare or Medicaid for prescriptions?

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Can I use private health insurance to cover my prescription from Universal Drugstore?

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Unievrsal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

How secure is my payment information when ordering from Universal Drugstore?

We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.

Can I order a generic alternative to Zestril?

Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

Do I need a prescription to order Zestril?

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription.

Can I order multiple medications at once?

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Can I refill my prescription through Universal Drugstore?

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Does Universal Drugstore offer discounts or price matching?

Yes! We offer:

  • Up to 80% savings on medications
  • Price match guarantee – we’ll match competitor pricing on qualifying medications
  • 10% off your first order for new customers

How can I contact Universal Drugstore for additional support?

We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.

Important

The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.