Zetia

The active ingredient in Zetia is ezetimibe. Zetia works by blocking the action of a protein called NPC1L1, which is responsible for transporting cholesterol from the intestines into the bloodstream. By inhibiting this protein, Zetia reduces the absorption of cholesterol from food, resulting in lower LDL blood cholesterol levels. Reducing LDL levels and maintaining healthy good cholesterol (HDL) levels may help prevent strokes and heart attacks. However, Zetia has not been shown to lower the risk of heart attacks, stroke, or heart disease

Unlike statins, which primarily target cholesterol production in the liver, Zetia offers a complementary mechanism of action. It can be used alone or in combination with statins to help lower LDL and triglyceride levels while also increasing HDL levels. This unique approach makes Zetia a valuable addition to the treatment options available for individuals struggling to lower cholesterol levels.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-approved product Labeling, Instructions for Use, and Medication Guide before using Zetia. However, the following is a synopsis of the general guidelines for the use of Zetia:

• Zetia should be taken once a day and can be taken with or without food.
• It is recommended to take your dose at the same time each day
• If you take more than one heart medicine to reduce your cholesterol, consult with your doctor to make sure when and how you should take your medications.
• If you take a medicine called a bile acid sequestrant (such as cholestyramine or colesevelam), you should take Zetia at least 2 hours before or 4 hours after you take the bile acid sequestrant medicine.
• If you miss a dose, do not take two doses at once. Instead, take your dosage as soon as you remember. If it is closer to the time of your next dose, skip your missed dose and take your next dose at its scheduled time.
• It is essential that you take your cholesterol-lowering medication along with diet and exercise as your healthcare provider instructs you to do.
• Your healthcare provider will likely do blood tests to check your LDL-C levels as soon as 4 weeks after starting your treatment with Zetia.

The most common side effects of Zetia seen in clinical trials as compared to placebo include:

• Joint pain
• Upper respiratory tract infection
• Diarrhea
• Inflammation of the sinuses
• Pain in your legs or arms
• Tiredness
• Flu-like symptoms
• Muscle pains and aches (if taken with a statin)
• Muscle problems, including muscle breakdown (rhabdomyolysis) can happen.
• Runny nose and sore throat (if taken with a statin)

Some individuals may experience serious side effects while using Zetia. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Serious, life-threatening allergic reaction. Symptoms could include:
• Swelling of the face, mouth, and lips.
• Trouble breathing
• Hives
• Liver damage or impaired liver function.
• Speak to your doctor about monitoring liver enzymes throughout your treatment with Zetia for the development of serious toxic hepatitis.

These are not all of the possible side effects of Zetia. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Zetia, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Liver problems, such as liver disease.
• Pregnant, plan to become pregnant, or are breastfeeding.
• Kidney disease or issues with your thyroid.

• Hypersensitivity to ezetimibe or any ingredient in Zetia.

• When used in combination with a fibrate or statin, fenofibrate, or other LDL-C lowering therapy which are contraindicated with Zetia. Speak to your healthcare provider and pharmacist to ensure your medications are not contraindicated.

It may take up to two weeks for the effects of ezetimibe to work. It is essential that you keep taking this medication even if you feel well. The majority of people with high cholesterol do not feel sick.

When Zetia is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking, in case of drug interactions, including:

• Cyclosporine
• Gemfibrozil
• Fenofibric acid
• Blood thinners, such as warfarin

Zetia is available as a 10 mg oral tablet.

Store Zetia at room temperature between 68ºF to 77ºF (20ºC to 25ºC) and protect it from moisture. Keep away from excess direct sunlight.

Zetia is manufactured by Merck and Schering-Plough Pharmaceuticals.

Lower-cost generics are available for the brand-name Zetia.

To stop taking Zetia, consult your doctor for guidance, as they can help determine the best approach for discontinuation. It’s important to monitor your cholesterol levels and overall health after stopping the medication to ensure they remain within a safe range.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you. It is currently unknown if Zetia is safe for pregnancy.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you. It is currently unknown if Zetia is safe for breastfeeding individuals.