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Buy Zostrix Online
(Capsaicin)

What is Zostrix?

What is Zostrix?

Zostrix (capsaicin) is a brand-name topical cream used for pain relief. It is applied directly to the skin for the management of certain nerve and muscle pain conditions. Zostrix is commonly used for postherpetic neuralgia following shingles, diabetic neuropathy, back pain, joint pain, muscle pain, sprains, and other minor aches. Zostrix is available over the counter (OTC) and may be recommended by a healthcare professional as part of a pain management or wellness plan.

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Purchase Zostrix from Universal Drugstore today and save!

Select your dosage:

  • All Strength's
  • 0.025%
  • 0.075%

Zostrix brand

Zostrix 
0.025%

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Product of Canada

Product of Canada

Zostrix HP 
0.075%

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Product of Canada

Product of Canada

Capsaicin (generic Zostrix)

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Important information about Zostrix

The active ingredient in Zostrix is capsaicin. Capsaicin is a topical analgesic derived from chili peppers and works by affecting substance P, a natural chemical in the body involved in transmitting nerve pain signals. With repeated use, capsaicin reduces the amount of substance P in the nerve endings of the treated area, which helps lower the sensation of nerve pain over time.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Zostrix. However, the following is a synopsis of the general guidelines for the use of Zostrix:

  • Zostrix is typically applied three to four times daily, or as directed by a healthcare provider.
  • To use Zostrix, apply a thin layer to the affected area. Gently rub the cream into the skin until fully absorbed. Wash hands thoroughly with soap and water after each application.
  • Avoid contact with eyes, mouth, nose, contact lenses, genitals, or broken skin.
  • Do not apply immediately before or after using a heating pad.
  • Zostrix is for external use only.

Some mild or common side effects of Zostrix seen in clinical use as compared to placebo include:

  • Burning sensation, stinging, or warmth at the application site.
  • Redness or mild skin irritation.
  • Itching or dryness of the treated area.
  • Sneezing or coughing from inhaling vapors.

Some individuals may experience serious side effects while using Zostrix. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Severe skin irritation, blistering, or swelling.
  • Signs of an allergic reaction, such as rash, hives, difficulty breathing, or swelling of the face or throat.
  • Persistent pain or worsening nerve pain after continued use.
  • Stop use and seek medical advice if severe irritation occurs.

Disclaimer: These are not all of the possible side effects of Zostrix. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Zostrix, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

  • Sensitive or irritated skin.
  • A history of allergic reactions to topical products.
  • Ongoing skin infections or rashes.
  • Reduced sensation in the area being treated, such as with diabetic neuropathy.
  • Do not use on broken skin, open wounds, or blistering areas.
  • Avoid bandaging or tightly covering the treated area unless advised by a healthcare professional.

  • Known allergy or hypersensitivity to capsaicin or any component of the product.

Zostrix does not provide immediate pain relief. Some people may notice a reduction in nerve pain after several days of consistent use, while full benefit may take up to two to four weeks. Continued application is important to maintain pain relief.

When Zostrix is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Other topical pain relievers may increase skin irritation when used on the same area.

Zostrix is available as a topical cream containing 0.025% capsaicin. There is also Zostrix HP Cream that contains 0.075% capsaicin.

It should be stored at room temperature, away from the reach of children or pets.

Zostrix is manufactured by Prestige Consumer Healthcare, Inc.

Yes. Generic capsaicin topical creams and gels are available under the generic name capsaicin.

Zostrix can be stopped at any time. If pain returns after stopping, talk to a healthcare provider for medical advice on alternative treatments. Do not apply extra doses to make up for missed doses.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. A healthcare professional will help determine if Zostrix is appropriate during pregnancy based on potential benefits and risks.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. Your healthcare provider can advise whether Zostrix is appropriate, and steps should be taken to avoid contact with the infant.

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Important information about buying Zostrix from UniversalDrugstore™

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.

Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Yes! We offer:

  • Up to 80% savings on medications
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  • 10% off your first order for new customers

We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.

Medical Disclaimer

The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.