Can you take ibuprofen with Eliquis?

Eliquis (apixaban) is an anticoagulant used to treat and prevent blood clots. Ibuprofen (Advil, Motrin) is a nonsteroidal anti‑inflammatory drug (NSAID) often used for pain or fever. Both affect clotting, so combining them can raise the risk of bleeding, especially in the gastrointestinal tract.

What is Eliquis?

Eliquis belongs to a class of medications called direct oral anticoagulants (DOACs). It blocks clotting factor Xa, slowing clot formation and lowering the chance of stroke, deep vein thrombosis (DVT), pulmonary embolism (PE), and clot recurrence after hip or knee replacement.

What is ibuprofen?

Ibuprofen relieves pain, reduces inflammation, and lowers fever. It works by inhibiting cyclooxygenase (COX) enzymes, which also play a role in platelet function and clotting.

Why the combination increases bleeding risk

  • Eliquis prolongs clotting time by inhibiting factor Xa.
  • Ibuprofen impairs platelet aggregation.
  • Together, they can cause minor to life‑threatening bleeding.

Talk with a healthcare professional before using ibuprofen while on Eliquis.

Other drug interactions with Eliquis

  • NSAIDs (aspirin, naproxen) increase bleeding risk.
  • SSRIs and SNRIs (fluoxetine, sertraline, venlafaxine) can also raise bleeding risk.
  • Other anticoagulants or antiplatelets (warfarin, heparin, clopidogrel).
  • Strong CYP3A4 inhibitors or inducers (ketoconazole, rifampin, phenytoin, St. John’s wort).
  • Grapefruit and grapefruit juice may alter apixaban levels.

This is not a complete list. Always consult your provider before adding any new medication, supplement, or herb.

Is acetaminophen (Tylenol) safe with Eliquis?

Acetaminophen does not affect clotting and is generally considered safe to use for pain or fever while taking Eliquis. Check product labels to avoid combination products that contain NSAIDs or other additives.

Alternative pain relief options

  • Topical analgesics (menthol creams, lidocaine patches).
  • Non‑drug approaches (massage, heat/cold therapy, physical therapy).
  • Prescription pain medications that do not increase bleeding risk (consult your provider).

Sources

  • Eliquis (apixaban) tablets, for oral use. Bristol Myers Squibb. Last updated 9/2021. Accessed Jan. 31, 2025.
  • What are direct‑acting oral anticoagulants (DOACs)? American Heart Association. Accessed Jan. 31, 2025.