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Weight Loss

Weight Loss

Over 75% of Americans are overweight or obese. An estimated 160 million people are dieting, spending more than $70 billion annually on weight-loss programs, medications, supplements, and other strategies. Sustainable weight loss relies on healthy lifestyle changes—balanced eating, regular activity, and stress management—rather than quick fixes or fad diets.

What is a healthy weight?

Body Mass Index (BMI) and waist circumference help screen for health risks. A BMI of 25–29.9 indicates overweight; over 30 indicates obesity. Weight loss is recommended for anyone with BMI over 30, or BMI 25–29.9 plus conditions such as type 2 diabetes, hypertension, or heart disease. A full health assessment should guide individual goals.

What causes weight gain?

Energy balance

Consuming more calories than you burn leads to weight gain.

Environment

  • Lack of safe places to exercise (parks, sidewalks, gyms)
  • Large portion sizes
  • Limited access to affordable fresh produce

Genetics

Genes may predispose some people to obesity, though lifestyle factors usually play a key role.

Medications and health conditions

  • Hormone imbalances (hypothyroidism, PCOS, Cushing’s syndrome)
  • Certain antidepressants, anticonvulsants, and corticosteroids

Stress and sleep

Poor sleep and high stress can disrupt appetite hormones, leading to increased calorie intake.

How to start losing weight

  • Work with a dietitian or healthcare provider for personalized guidance
  • Adopt regular physical activity (aim for ≥150 minutes of moderate exercise weekly)
  • Consider medication if lifestyle changes alone aren’t enough—options include liraglutide, semaglutide, tirzepatide, orlistat, and bupropion/naltrexone

What’s a healthy diet for weight loss?

There is no one “best” diet, but most effective plans share these features:

  • Plant-based emphasis
  • Whole, minimally processed foods
  • Healthy fats in moderation (olive oil, avocado, nuts, seeds)
  • Limited added sugars and refined carbs
  • Balanced meals: protein, complex carbs, vegetables, and healthy fats

Protein sources:

  • Legumes and beans
  • Nuts and seeds
  • Fish and lean poultry
  • Low-fat dairy

Vegetables: Aim for about 2½ cups daily (leafy greens, bell peppers, tomatoes, squash). Note that starchy vegetables (potatoes, corn) count toward your carbohydrate portion.

Key points

  • Set realistic, gradual goals (1–2 pounds per week)
  • Track progress and celebrate milestones
  • Combine diet, exercise, and stress management
  • Seek professional support for best outcomes

Resources

Weight Loss FAQ's

GLP-1 receptor agonists like Wegovy (semaglutide) and Saxenda (liraglutide) are among the most clinically effective weight loss medications available, helping reduce appetite and slow gastric emptying. They are typically prescribed for adults with a BMI of 30+ or 27+ with a weight-related health condition, and work best alongside dietary and lifestyle changes.

GLP-1 medications can be expensive if purchased in the U.S. Sourcing through a licensed international pharmacy can offer significant savings, often 40–70% lower than U.S. retail, on the same brand-name medications, shipped directly to your door.

Yes. All prescription weight loss medications, including GLP-1 agonists like Wegovy and Saxenda, require a valid prescription and ongoing medical supervision. This ensures the medication is appropriate for your health profile, dosed correctly, and monitored for any side effects over time.

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Compare Weight Loss Medications

  • GLP-1
Indicated UseFormatDose FrequencyTypical DosePrice TierDrug ClassActive Ingredient
Wegovy
(Semaglutide)
Chronic weight management (adults + adolescents ≥12); reduces cardiovascular (CV) events in adults with CV Disorder + overweight/obesity; MASH with moderate to advanced liver fibrosis (not cirrhosis) in adultsPrefilled subcutaneous injection penOnce weekly2.4 mg weekly maintenanceHighGLP‑1 receptor agonistSemaglutide
Ozempic
(Semaglutide)
Type 2 diabetes; reduces CV risk; reduces CKD progression & CV death in adultsPrefilled subcutaneous injection penOnce weekly1 mg weekly penMediumGLP‑1 receptor agonistSemaglutide
Zepbound
(Tirzepatide)
Chronic weight management; FDA-approved for moderate–severe OSA in adults with obesityPrefilled subcutaneous injection penOnce weekly5 mg weeklyMediumDual GIP/GLP‑1 receptor agonistTirzepatide
Mounjaro
(Tirzepatide)
Type 2 diabetes (glycemic control) in adultsPrefilled subcutaneous injection penOnce weekly5–10 mg weeklyMedium–HighDual GIP/GLP‑1 receptor agonistTirzepatide
Trulicity
(Dulaglutide)
Type 2 diabetes (adults & peds ≥10); reduces CV risk in adultsPrefilled subcutaneous single-dose penOnce weekly1.5 mg weeklyHighGLP‑1 receptor agonistDulaglutide
Rybelsus
(Semaglutide)
Type 2 diabetes (oral therapy) in adultsOral tabletOnce daily (empty stomach)7 mg dailyMediumGLP‑1 receptor agonist (oral)Semaglutide