Canasa Suppository

The active ingredient in Canasa is mesalamine. It is also known as 5-aminosalicylic acid (5-ASA). It is an anti-inflammatory that will decrease the inflammation that can be seen in the colon. It can be used to decrease severe symptoms, including rectal bleeding.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Canasa suppository. However, the following is a synopsis of the general guidelines for the use of Canasa suppository:

• This medication is indicated for rectal use and can be used once daily at bedtime. For best results, use Canasa after you have had a bowel movement.
• The rectal suppository is used as follows:
• Take off the wrapper. If the suppository is soft, keep it in the refrigerator for a few minutes.
• Place your right knee close to your chest while lying on your left side. Ensure the pointed tip is facing up, and then carefully insert the suppository 1 inch into your rectum.
• Remain in this prone position and keep the suppository for at least 1 hour.
• Ensure a sun safety routine is practiced, which includes a broad-spectrum sunscreen with at least SPF 30 and wearing protective clothing.
• If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose.

The most common side effects of Canasa suppositories seen in clinical trials include:

• Dizziness
• Rectal pain
• Rash
• Inflammation in the colon
• Increased sun sensitivity

Some individuals may experience serious side effects while using Canasa suppositories. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Allergic reaction: trouble breathing, hives or skin rash, enlarged lymph nodes, or swelling of the face, eyes, or tongue.
• Inflammation in the heart: chest pain, heart palpitations, or shortness of breath
• Kidney damage: decreased urination, fatigue, and swelling of the legs, feet, arms, or hands
• Kidney stones: Lower back pain, bloody urine, and stomach pain
• Acute Intolerance Syndrome: abdominal pain, cramping, and bloody diarrhea
• Liver problems: yellowing of the eyes and skin, loss of appetite, or dark urine

These are not all of the possible side effects of Canasa suppository. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Canasa suppositories, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Kidney problem
• History of pericarditis (inflammation of the lining around your heart)
• Liver damage
• Hypersensitivity to sulfasalazine
• Obstruction in the upper GI tract
• Skin problems like eczema

Do not use Canasa Suppositories if you have:

• Known allergy to salicylates or aspirin
• Known allergy to mesalamine or any of its inactive ingredients

The mesalamine suppositories will improve symptoms within 1 - 3 weeks.

When Canasa is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Azathioprine
• 6-mercaptopurine
• NSAIDs (nonsteroidal anti-inflammatory drugs)

The dosage forms available include Canasa rectal suppositories. The strength available includes a 1000 mg suppository.

This medication should be stored at room temperature and may be kept in the refrigerator. This medication should be kept away from light and extreme temperatures, and out of reach of children.

The pharmaceutical company that manufactures Canasa is Aptalis Pharma Canada.

There are lower-cost alternatives to the brand-name Canasa.

Before stopping this medication, consult your healthcare provider, as tapering is required for this medication.

It is unknown if Canasa can cause harm to your unborn child. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Canasa can pass into the breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.