Doryx

(Doxycycline Hyclate)

The active ingredient in Doryx is doxycycline hyclate. It is a tetracycline antibiotic that works by stopping bacteria from making proteins they need to grow and survive. This mechanism of action helps the immune system clear the infection.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Doryx. However, the following is a synopsis of the general guidelines for the use of Doryx:

• Take Doryx exactly as prescribed by your healthcare provider.
• Doryx delayed-release tablets are taken by mouth. Take each dose with a full glass of water to reduce throat irritation. Swallow tablets whole, or if directed, the tablet may be sprinkled on applesauce and swallowed immediately without chewing. Take it while sitting or standing upright. Avoid lying down for at least 30 minutes after taking a dose.
• Doryx may be taken with food if stomach upset occurs.
• Avoid taking antacids, calcium, magnesium, iron, or bismuth subsalicylate close to your Doryx dose.
• Use sunscreen and protective clothing while taking Doryx due to photosensitivity risk.
• Pediatric use may affect tooth development.

Some mild or common side effects of Doryx include:

• Nausea.
• Diarrhea.
• Vomiting.
• Abdominal pain.
• Sun sensitivity or sunburn.

Some individuals may experience serious adverse reactions while using Doryx. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Severe allergic reaction, including swelling of the face or throat.
• Severe skin reactions such as exfoliative dermatitis, erythema multiforme, or toxic epidermal necrolysis.
• Intracranial hypertension may cause severe headache or vision changes.
• Tooth discoloration or effects on tooth development in pediatric patients.
• Severe diarrhea that does not go away.
• Liver problems, including jaundice.
• Blood disorders such as hemolytic anemia or eosinophilia.

These are not all of the possible side effects of doxycycline. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Doryx, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

• A history of allergic reactions to tetracycline antibiotics.
• Liver disease.
• Kidney problems.
• Intracranial hypertension.
• Esophageal disorders.
• A history of severe skin reactions.
• Conditions that affect blood cell production.
• Myasthenia gravis.
• If you are a woman of childbearing age.

• Known hypersensitivity to doxycycline.
• A history of severe allergic reaction to tetracyclines like minocycline.
• Children under 8 years of age, unless benefits outweigh risks.

You will typically begin to feel better within a few days. However, the time before you see the full effects will depend on the type and severity of the bacterial infection. It’s important to complete the full prescribed course even if you feel better.

When Doryx is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Antacids containing calcium or magnesium reduce doxycycline absorption.
• Iron supplements reduce antibiotic effectiveness.
• Bismuth subsalicylate interferes with absorption.
• Penicillin antibiotics may reduce antibacterial effectiveness.
• Phenytoin or carbamazepine may lower doxycycline levels.
• Barbiturates may reduce doxycycline blood concentrations.
• Isotretinoin or acitretin may increase the risk of intracranial hypertension.
• Oral contraceptives may have reduced effectiveness.

Doryx is available in the following dosage forms and strengths: 75 mg, 100 mg, and 150 mg delayed-release tablets. Your healthcare provider will determine the appropriate dose based on the type of infection and the patient's age.

Doryx MPC is also available in a 60 mg delayed-release tablet.

It should be stored at room temperature, away from the reach of children or pets.

Doryx is manufactured by Mayne Pharma.

Yes. Doryx is available in generic delayed-release formulations. The generic name is doxycycline hyclate.

Do not stop taking Doryx early without medical advice because stopping treatment too soon may allow the infection to return. Follow your healthcare provider’s instructions for discontinuation.

Doryx is generally not recommended during pregnancy due to potential effects on fetal tooth and bone development. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. Your healthcare provider will determine the best treatment option.

Doryx may pass into breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. Your healthcare provider will help weigh the benefits and potential risks.