Duaveeand/or alternativesChemical Ingredient: Estrogens, Conjugated/Bazeoxifene Acetate
What is a generic medication?
Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.
No generic is available for Duavee 0.45/20mg.
- Marketed as Duavive in United Kingdom
- Manufactured by Merck Sharp & Dohme
- Product of United Kingdom • Shipped from United Kingdom
- Prescription Required
No generic is available for Duavee 0.45/20mg.
Duavee Drug Information
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Duavee Drug Information
Duavee is a combination product containing conjugated estrogens and bazedoxifene (an estrogen agonist/antagonist). Duavee is used by women with a uterus to help reduce symptoms of menopause (such as hot flashes, vaginal dryness) and to prevent bone loss (osteoporosis) after menopause. Conjugated estrogens are female hormones which help to decrease menopausal symptoms caused by the body making less estrogen. Bazedoxifene is not a hormone, but works by acting like estrogen (as a selective estrogen receptor modulator or SERM) in some parts of the body. The bazedoxifene in Duavee helps to preserve bone mass and reduces the risk of cancer of the uterus which can be caused by using estrogen. If you are using Duavee to treat symptoms only in and around the vagina, consider using products applied directly inside the vagina instead of medications that are taken by mouth, absorbed through the skin, or injected.
Women taking Duavee should not take additional estrogens, progestins, or additional estrogen agonist/antagonists (see also Drug Interactions section). Estrogens, either used alone or with another hormone (progestin), have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens should not be used to prevent heart disease or dementia. Estrogens can increase the risk of cancer of the uterus (endometrial cancer). The bazedoxifene in Duavee may help decrease this risk. Tell your doctor right away if you have any unusual vaginal bleeding. In postmenopausal women, estrogens can increase the risk of cancer of the ovaries, stroke, dementia, and serious blood clots in the legs. Estrogens alone do not appear to increase the risk of breast cancer when used for up to 7 years. Estrogen, when used with a progestin, can increase the risk of heart disease (such as heart attacks), stroke, serious blood clots in the lungs/legs, dementia, and cancer of the breast/ovaries. The risk for serious side effects may depend on the dose of estrogen and the length of time Duavee is used. Therefore, Duavee should be used at the lowest effective dose and for the shortest amount of time. Discuss the use of Duavee with your doctor and check with him/her regularly (for example, every 3 to 6 months) to see if you still need to take Duavee. If you will be taking Duavee long-term, you should have regular complete physical exams (for example, once a year) as directed by your doctor. See also Notes section.
How to Use Duavee
Read the Patient Information Leaflet if available from your pharmacist before you start using Duavee and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take Duavee by mouth with or without food as directed by your doctor, usually once daily. You may take it with food or right after a meal to prevent stomach upset. Swallow the tablet whole. Do not chew or crush. Doing so can release all of the drug at once, increasing the risk of side effects. Also do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. The Dosage of Duavee is based on your medical condition and response to treatment. Take Duavee regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not increase your dose or take Duavee more often or for a longer time than directed. Tell your doctor if your condition does not improve or if it worsens.
Before taking Duavee, tell your doctor or pharmacist if you are allergic to conjugated estrogens or bazedoxifene; or if you have any other allergies. Duavee may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Duavee, tell your doctor or pharmacist your medical history,vaginal bleeding of unknown cause, diabetes, cancer (especially breast cancer, cancer of the uterus/ovaries), blood clots, blood clotting disorders (such as protein C or protein S deficiency), family medical history (especially of breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), gallbladder disease, heart disease (such as irregular heartbeat, previous heart attack), high blood pressure, high cholesterol/triglyceride levels, kidney disease, liver disease, lupus, mental/mood disorders (such as dementia, depression), migraine headaches, underactive thyroid (hypothyroidism), mineral imbalance (low or high level of calcium in the blood), obesity, a certain hormone problem (hypoparathyroidism), uterus problems (such as fibroids, endometriosis), asthma, seizures, stroke, a certain blood disorder (porphyria). Do not smoke or use tobacco. Estrogens combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35. Tell your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time (such as a long plane flight). These conditions increase your risk of getting blood clots, especially if you are taking an estrogen product. You may need to stop Duavee for a time or take special precautions. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Duavee may cause blotchy, dark areas on your face and skin (melasma). Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Contact your eye doctor if these problems occur. Duavee must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor right away. Estrogens pass into breast milk and may reduce the quality and amount of breast milk produced. It is unknown if bazedoxifene passes into breast milk. Breastfeeding is not recommended while using Duavee. Consult your doctor before breastfeeding.
If you miss a dose of Duavee, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.aromatase inhibitors (such as anastrozole, exemestane, letrozole), other estrogen agonist/antagonists (such as ospemifene, raloxifene), fulvestrant, tamoxifen, tranexamic acid. Duavee may interfere with certain laboratory tests (including metyrapone test, blood clotting tests, thyroid tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Duavee.
Duavee Side Effects
Stomach upset, nausea/vomiting, bloating, breast tenderness, headache, or weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed Duavee because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Duavee do not have serious side effects. Tell your doctor right away if you have any serious side effects,lumps in the breast, mental/mood changes (such as depression, memory loss), persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes/skin, dark urine, swelling hands/ankles/feet, increased thirst/urination, unusual vaginal bleeding (such as spotting, sudden heavy bleeding). Duavee may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Duavee may rarely cause serious problems from blood clots (such as heart attacks, strokes, deep vein thrombosis, pulmonary embolism). Get medical help right away if you have any serious side effects,chest/jaw/left arm pain, confusion, coughing up blood, pain/swelling/warmth in the groin/calf, slurred speech, sudden dizziness/fainting, sudden/severe headache, sudden vision changes (such as partial/complete blindness), tingling/weakness/numbness in the arms/legs, trouble breathing, unusual sweating, weakness on one side of the body. A very serious allergic reaction to Duavee is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.List of Duavee side effects
Store in the original package at room temperature away from light and moisture. Do not store in the bathroom. After opening the foil pouch, use the US product within 60 days and the Canadian product within 45 days. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Duavee when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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