Frova

The active ingredient in Frova is frovatriptan succinate, which is a triptan or serotonin (5-HT1) receptor agonist. It targets serotonin receptors in the brain and neurological system. Serotonin is a natural substance in your body that may contribute to migraines.

When Frova binds to serotonin receptors in the brain, it constricts the blood vessels and reduces swelling. This helps to alleviate migraine pain. The medicine also relieves migraine pain by preventing other pain signals from being released by the neurological system.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Frova. However, the following is a synopsis of the general guidelines for the use of Frova:

• Take Frova as soon as you have headache symptoms. If your first dose does not work, you can take a second dose as long as it has been at least 2 hours since the first one.
• Never use more than the specified dosage. Overuse of migraine headache medications can exacerbate symptoms or cause medication-overuse headache. Inform your doctor if the medication no longer appears to be as effective in treating your migraines.
• Take one tablet whole, with a full glass of water.

The most common side effects of frovatriptan placebo include:

• Dizziness.
• Drowsiness.
• Tiredness.
• Headache.
• Dry mouth.
• Stomach pain.
• Indigestion.
• Chest pain.
• Tingling or pins and needles in your hands and legs.
• Flushing.

Some individuals may experience serious side effects while using Frova. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Heart attack symptoms include intense chest pain that may spread to the arms, neck, or jaw, as well as shortness of breath, perspiration, nausea, and heartburn.
• Irregular heart rhythm (arrhythmia) symptoms include slowed heart rate, skipped heartbeats, hammering in the chest, a fluttering sensation, chest discomfort, dizziness, weakness, and difficulty breathing.
• Stroke symptoms include sudden weakness on one side of the body, drooping facial muscles, severe headaches, abnormalities in speech or vision, and confusion.
• Extremely high blood pressure symptoms include severe headaches, confusion, blurred vision, chest pain, difficulty breathing, nausea, and a racing heart.
• Serotonin syndrome symptoms include fever, sweating, shivering, a fast heartbeat, anxiety, confusion, mobility issues, and seizures.
• Serious, life-threatening allergic reactions include difficulty breathing, a rash, hives, and swelling of the face, tongue, or throat.
• Changes in color or sensation in your fingers and toes (Raynaud’s syndrome).

These are not all of the possible side effects of Frova. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Frova, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you have:

• Heart problems like heart disease, uncontrolled hypertension (high blood pressure), irregular heartbeats, stroke, or transient ischemic attack (mini-stroke).
• Coronary artery disease, angina (chest pain), blood circulation problems, and a lack of blood supply to the heart. Or risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or being older than 40 and a man).
• Circulation problems affect your legs, arms, stomach, intestines, or kidneys.
• Wolff-Parkinson-White syndrome.
• Severe liver disease or kidney disease.

• Coronary Artery Disease (CAD).
• Prinzmetal's angina is an example of coronary artery vasospasm.
• Wolff-Parkinson-White syndrome is one of several medical diseases that produce an abnormal heartbeat (arrhythmia).
• History of a stroke or transient ischaemic attack ("mini-stroke").
• A history of hemiplegic or basilar migraines.
• Unmanaged high blood pressure.
• Peripheral vascular disease.
• Ischemic Bowel Disease.
• Have taken an ergot-containing or ergot-type drug, such as dihydroergotamine (Migranal), during the last 24 hours.
• Have taken a different triptan in the last 24 hours.

According to studies, most people have relief from a migraine after 2 hours of using Frova. However, it may take up to four hours to completely relieve a migraine headache.

When Frova is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Ergotamine.
• Rizatriptan.
• Almotriptan.
• Sumatriptan (Imitrex).
• Zolmitriptan.
• Naratriptan.
• Eletriptan.
• Methysergide.

The typical dose of frovatriptan for migraine attacks is 2.5 mg taken orally once.

If your migraine returns or does not entirely resolve, take another dose 2 hours after the first. Take no more than 7.5 mg (3 pills) in a 24-hour period.

Store Frova at room temperature and keep it out of reach of children.

Endo Pharmaceuticals Inc. is the company that manufactures Frova.

Yes, there are several lower-cost generics available of Frova.

Frova is typically taken as needed for migraine headaches. If it is not working for you or you are having bothersome side effects and want to stop taking it, call your healthcare provider.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.