Glucosamine Sulfate

The active ingredient in glucosamine sulfate is glucosamine. Glucosamine sulfate, glucosamine hydrochloride, and N-acetyl glucosamine are the major salt forms of glucosamine. Glucosamine is found in the body and is a building block of connective tissue, synovial fluid, and cartilage. Taking glucosamine supplements may slow down the breakdown of cartilage and synovial fluid. Glucosamine may also have anti-inflammatory effects similar to nonsteroidal anti-inflammatory drugs (NSAIDs). Through these mechanisms, glucosamine sulfate supports the treatment of osteoarthritis, knee pain, and joint wellness.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using glucosamine sulfate. However, the following is a synopsis of the general guidelines for the use of glucosamine sulfate:

• The recommended dose is glucosamine sulfate 400 mg 2 to 3 times a day. Your healthcare provider may recommend a specific dose for you.
• Oral glucosamine sulfate is the most common way to take glucosamine supplements. It is often in capsule dosage form.
• Glucosamine is made from shells of shellfish, so avoid using glucosamine if you have a severe shellfish allergy.
• Some glucosamine products may contain chondroitin sulfate, which is also indicated for osteoarthritis pain management.
• Glucosamine sulfate can also be written as glucosamine sulphate.

The most common side effects of glucosamine sulfate seen in clinical trials as compared to placebo include:

• Abdominal pain.
• Bloating.
• Diarrhea.
• Constipation.
• Nausea.
• Heartburn.

Some individuals may experience serious side effects while using glucosamine sulfate. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Allergic reaction. Signs include hives, rash, or swelling of the face, lips, and tongue.

These are not all of the possible side effects of glucosamine sulfate. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting glucosamine sulfate, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you have:

• Shellfish allergy. Glucosamine is made from the shells of shellfish.
• Asthma.
• Diabetes. Glucosamine may increase blood sugars (glucose), but there is limited research to support this.
• Glaucoma.
• High blood pressure.
• High cholesterol.

Allergic reaction to any ingredient in the glucosamine sulfate supplement formulation.

You will start to feel the positive effects of glucosamine sulfate in 4 weeks of continuous use, although in some people it may take longer.

When glucosamine sulfate is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Warfarin (anticoagulant). Glucosamine sulfate may increase the effects of warfarin, leading to serious bleeding.
• Topoisomerase II inhibitors. These medications are used to treat cancer, and glucosamine may decrease their effects.
• Acetaminophen.

Multiple doses of glucosamine sulfate are available for purchase. The most common doses are 500 mg and 750 mg of glucosamine sulfate per capsule. Other combination products of glucosamine chondroitin contain 500 mg glucosamine and 400 mg chondroitin per capsule.

Store glucosamine sulfate at room temperature, keep away from children and pets.

Multiple pharmaceutical companies manufacture glucosamine sulfate supplements.

Glucosamine sulfate is the generic version.

There are no withdrawal symptoms associated with glucosamine sulfate, but your symptoms of osteoarthritis may worsen. It is always best to consult your healthcare professional before stopping any medication or dietary supplement.

There is limited research about the use of glucosamine sulfate in pregnancy. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

There is limited research about the use of glucosamine sulfate in pregnancy. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.