Ibsrela

The active ingredient in Ibsrela is tenapanor hydrochloride, which is an inhibitor of sodium/hydrogen exchanger 3 (NHE3). The mechanism of action involves blocking the gut's ability to absorb salt into the body. More water enters your intestines as a result, softening your stool and keeping it going through your digestive tract so you can use the bathroom.

To alleviate stomach pain, Ibsrela also acts on the nerves in your stomach.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Ibsrela. However, the following is a synopsis of the general guidelines for the use of Ibsrela:

• Follow your doctor's instructions exactly when taking Ibsrela.
• Take one Ibsrela pill orally, twice daily.
• Before breakfast or the first meal of the day, as well as right before dinner, take the tablets.
• Speak to your healthcare provider first, as they can help determine whether Ibsrela, Linzess (linaclotide), Amitiza (lubiprostone), or another alternative may be the best treatment option for your IBS-C.

The most common side effects of Ibsrela seen in clinical trials include:

• Stomach bloating.
• Diarrhea.
• Dizziness.
• Gas.
• Bleeding in the rectum.
• Abdominal pain.

Some individuals may experience serious side effects while using Ibsrela. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Serious dehydration manifests as dry skin, intense thirst, rapid breathing, heartbeat, difficulty urinating, dark yellow urine, fatigue, headache, lightheadedness, and fainting.
• Severe diarrhea.

These are not all of the possible side effects of Ibsrela. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Ibsrela, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions.

• Are pregnant or plan on becoming pregnant.
• Are breastfeeding or plan to breastfeed.
• Known or suspected GI blockage.

Boxed Warning

• It is not advised to use Ibsrela on patients younger than six. Tenapanor treatment resulted in mortality in nonclinical investigations with immature juvenile rats, which were thought to be brought on by dehydration. Additionally, Ibsrela should not be used on patients younger than twelve. Furthermore, there is no proof that Ibsrela is safe or effective for use in those younger than 18.

• Pediatric patients under six years of age.
• Physical obstruction in the digestive tract or gut that prevents normal passage, whether known or suspected.

Within a week of beginning Ibsrela, participants in clinical trials began to experience relief from IBS-C symptoms, such as constipation and stomach pain. However, the full benefits of the medicine may not be felt for a few weeks or months. If you have any concerns about the effectiveness of Ibsrela, get in touch with your prescriber.

When Ibsrela is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions.

There are no specific interactions of Ibsrela, however, it is best to speak to your doctor first.

The usual dose of Ibsrela is a 50 mg tablet taken orally twice a day, just before breakfast and shortly before dinner.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.

Store at room temperature and keep out of reach of children.

Ardelyx is the pharmaceutical manufacturer of Ibsrela.

There are no lower-cost generics available for Ibsrela.

If your doctor does not advise you to discontinue taking Ibsrela, do not do so.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.