Lincocin

(Lincomycin Hydrochloride)

The active ingredient in Lincocin is lincomycin hydrochloride. It is a lincosamide antibiotic first isolated from the soil bacterium Streptomyces lincolnensis in Lincoln, Nebraska.

Lincosamides’ mechanism of action works by binding to bacterial ribosomes and blocking protein synthesis, preventing the bacteria from multiplying. This allows the body’s immune system to clear the infection, making Lincocin effective against certain serious bacterial infections, especially those caused by gram-positive bacteria.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Lincocin. However, the following is a synopsis of the general guidelines for the use of Lincocin:

• Lincocin is given by intramuscular or intravenous injection.
• The injection is administered by a healthcare professional.
• Dosing depends on the type and severity of the bacterial infection.
• Treatment duration is based on clinical response and laboratory results.
• Do not miss scheduled doses, as this may reduce treatment effectiveness.
• Patients receiving Lincocin are monitored closely for response to therapy and for possible adverse effects, especially gastrointestinal symptoms.

Some mild or common side effects of Lincocin include:

• Diarrhea.
• Nausea or vomiting.
• Stomach cramps or abdominal pain.
• Pain, redness, or swelling at the injection site.
• Skin rash or itching.

Some individuals may experience serious side effects while using Lincocin. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Severe or persistent diarrhea, which may be a sign of colitis or Clostridium difficile infection.
• Allergic reactions such as hives, swelling of the face or throat, or trouble breathing.
• Severe skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, or generalized exanthematous pustulosis.
• Signs of liver or kidney impairment.
• Life-threatening reactions, including gasping syndrome in infants due to a preservative (benzyl alcohol) that is in the formulation.

These are not all of the possible side effects of Lincocin. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Lincocin, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

• A history of colitis or severe diarrhea related to antibiotic use.
• Meningitis.
• Kidney disease or impaired renal function.
• Liver disease.
• A known allergy to lincomycin or clindamycin.
• A history of severe skin reactions to Lincocin or related antibacterial agents.

Boxed Warning

Lincocin has a boxed warning for severe and potentially fatal colitis associated with antibiotic use, including Clostridium difficile–associated diarrhea. This condition may occur during or after treatment and requires immediate medical attention.

Lincomycin is contraindicated in patients with a known hypersensitivity to lincomycin or clindamycin.

Lincocin may begin working within a few days of starting treatment, but improvement depends on the severity and location of the infection. Full treatment must be completed as prescribed to prevent bacterial resistance.

When Lincocin is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Clindamycin, which has overlapping activity and may increase the risk of adverse effects and toxicity.
• Erythromycin and other macrolides, which may reduce antibacterial effectiveness due to competition at bacterial ribosomes.
• Neuromuscular blocking agents, which may have enhanced effects when used with lincosamide antibiotics.

Lincocin is available as an injectable solution.

• Typical dosing based on source information includes:
• Adults: 600 mg to 1,000 mg of lincomycin is given intramuscularly or intravenously every 8 to 12 hours, depending on infection severity.
• Serious infections may require higher or more frequent dosing under close medical supervision.
• Pediatric dosing is weight-based and determined by a healthcare provider.
• Dose adjustments may be needed for patients with kidney or liver impairment.

It should be stored at room temperature, away from the reach of children or pets.

Lincocin is manufactured by Pfizer.

Yes, Lincocin is available as a generic medication under the name lincomycin hydrochloride.

Do not stop treatment early unless directed by your healthcare provider. Stopping too soon may allow the infection to return or worsen.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. Lincocin should only be used during pregnancy if clearly needed and if the potential benefits outweigh the risks.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. Lincomycin may pass into breast milk and could cause side effects in a nursing infant, including diarrhea or fungal overgrowth.