Lofibra

The active ingredient in Lofibra is fenofibrate. Fenofibrate helps reduce triglycerides and improve cholesterol levels by affecting the way the body processes fats. It supports a healthier lipid balance by lowering LDL and triglycerides while helping raise HDL cholesterol. Your healthcare provider will monitor these levels to ensure the medicine is working safely.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Lofibra. However, the following is a synopsis of the general guidelines for the use of Lofibra:

• Take Lofibra exactly as prescribed, usually once daily.
• Some formulations are taken with food, while others may be taken without food. Follow your healthcare provider’s instructions for your specific product.
• Swallow tablets or capsules whole with water.
• Continue following a cholesterol-lowering diet while taking this medicine.
• For a missed dose, take it as soon as you remember unless it is close to the next dose. Do not take extra doses.
• Your healthcare provider may monitor liver enzymes, kidney function, and cholesterol levels during treatment.

Some mild or common side effects of fenofibrate seen in clinical trials as compared to placebo include:

• Abdominal pain or stomach pain.
• Back pain.
• Constipation.
• Flatulence.
• Dizziness.
• Muscle pain.
• Nausea.
• Elevated liver enzymes.
• Mild rash or itching.
• Weight loss.
• Chest pain.
• Anemia.

Some individuals may experience serious side effects while using Lofibra. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Muscle tenderness, weakness, or dark urine (possible myopathy or rhabdomyolysis).
• Severe abdominal pain, nausea, or vomiting (possible pancreatitis).
• Jaundice, dark urine, or upper abdominal pain (possible liver problems).
• Severe skin reactions, including blistering or peeling, may indicate Stevens-Johnson syndrome.
• Signs of gallstones include sharp right-sided abdominal pain.
• Allergic reactions, including hives, swelling, or difficulty breathing.

These are not all of the possible side effects of Lofibra. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Lofibra, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

• Liver disease or a history of liver problems.
• Kidney impairment.
• Gallbladder disease or a history of gallstones.
• Hypothyroidism.
• A history of pancreatitis.
• A previous allergic reaction to fenofibrate or other fibrates.
• High alcohol intake can worsen liver problems.
• Muscle disorders or unexplained muscle pain.
• Use of other cholesterol medications, especially statins.

Lofibra should not be used in individuals who have:

• Active liver disease.
• Severe kidney disease.
• Gallbladder disease.
• Allergic to fenofibrate or any ingredient in the medication.
• Breastfeeding infants, unless a healthcare provider recommends otherwise.

Many people begin to see improvement in triglyceride and cholesterol levels within several weeks of consistent use. Full benefits may take up to 2 to 3 months, depending on diet, lifestyle, and medical history. Your healthcare provider will monitor progress through routine lab tests.

When Lofibra is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Warfarin. May increase the blood-thinning effect.
• Statins (such as simvastatin, atorvastatin, rosuvastatin, pravastatin, lovastatin, fluvastatin, pitavastatin). Increased risk of muscle problems.
• Bile acid sequestrants (cholestyramine, colestipol). Can reduce absorption of Lofibra.
• Cyclosporine. May increase the risk of kidney problems.
• Colchicine. May raise the risk of myopathy.

Lofibra is available in several tablet and capsule formulations, depending on the manufacturer. Common strengths include:

• 54 mg tablets.
• 67 mg capsules.
• 134 mg capsules.
• 160 mg tablets.

Both micronized and non-micronized versions exist, and dosing (mg/day) may vary based on the formulation. Your healthcare provider will choose the correct strength for your condition.

Store at room temperature, away from the reach of children or pets.

Lofibra is manufactured by Teva Pharmaceuticals. Some versions are also produced by other pharmaceutical companies, depending on the dosage form and region.

Yes. Generic fenofibrate is widely available in multiple strengths and formulations.

Do not stop taking Lofibra without guidance from your healthcare provider. Stopping treatment suddenly may cause cholesterol or triglyceride levels to rise.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. There is limited information on fenofibrate use during pregnancy, and your healthcare provider will determine whether the benefits outweigh potential risks.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. Fenofibrate should generally be avoided during breastfeeding because it may pass into breast milk.