Lovaza

The active ingredient in Lovaza is omega-3-acid ethyl esters, also known as omega-3 fatty acids. Omega-3 fatty acids are naturally found in certain fish oils, like salmon. Lovaza specifically contains eicosapentaenoic acid-ethyl ester (EPA) and docosahexaenoic acid-ethyl ester (DHA). The mechanism of action is that these omega-3-acid ethyl esters reduce triglyceride production by the liver. Although the details are not known, Lovaza decreases the production of low-density lipoprotein (LDL) and increases the production of high-density lipoprotein (HDL). As a result, Lovaza causes lower triglyceride levels.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Lovaza. However, the following is a synopsis of the general guidelines for the use of Lovaza:

• Follow the directions from your healthcare professional. The recommended daily dose of Lovaza is 4 capsules taken at the same time or 2 capsules two times a day. Do not take more than 4 capsules per day.
• While taking Lovaza, your doctor should also start you on a low-cholesterol and low-fat diet. You should continue this diet while you are on Lovaza.
• Lovaza should be taken at the same time each day.
• Lovaza can be taken with or without food.
• Lovaza is meant for adult use only (18 years or older).
• Do not split, crush, or open the Lovaza capsules.
• While taking Lovaza, your doctor should do blood tests to check your cholesterol levels and liver function. Lovaza may affect ALT and AST levels, which are part of the liver function tests.

The most common side effects of Lovaza seen in clinical trials as compared to placebo include:

• Burping.
• Infection.
• Upset stomach.
• Back pain.
• Skin rash.
• Flu symptoms.
• Change in sense of taste.
• Constipation.

Some individuals may experience serious side effects while using Lovaza. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Allergic reaction. Signs and symptoms include hives, nausea, vomiting, and swelling of the face, lips, or tongue.

These are not all of the possible side effects of Lovaza. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Lovaza, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Diabetes.
• Hypothyroidism.
• Liver problems.
• Pancreas problems like pancreatitis.
• Allergy to shellfish.
• Pregnant or breastfeeding.
• Drink more than 2 glasses of alcohol per day.
• Atrial fibrillation. Lovaza may increase recurrences of atrial fibrillation or atrial flutter in patients with atrial fibrillation.

• Allergy or hypersensitivity reaction to any ingredients in the formulation of Lovaza.

It may take months for Lovaza to effectively lower triglyceride levels. This can be confirmed with blood tests by your doctor.

When Lovaza is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Alcohol.
• Anticoagulants or blood thinners like aspirin, warfarin, and clopidogrel.

The dosage form of Lovaza is 1-gram capsules. Each capsule contains 465 mg EPA and 375 mg DHA.

Store Lovaza at room temperature, out of reach of children and pets.

Waylis Therapeutics manufactures Lovaza.

Yes, generic versions of Lovaza are available for purchase.

Do not stop taking Lovaza unless advised by your healthcare professional. It is always best to consult your healthcare professional before stopping any medication.

There is limited human data to determine if Lovaza is safe when used in pregnancy. In animal studies, Lovaza does not appear to be teratogenic. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

There is human data to show that EPA and DHA appear in breastmilk, but it is unknown what the effects are on the infant. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.