Maxzide

(Triamterene/Hydrochlorothiazide)

The active ingredients in Maxzide are hydrochlorothiazide and triamterene. Hydrochlorothiazide is a thiazide diuretic that increases the amount of water and salt you lose in your urine. This lowers the total fluid in your blood vessels and helps bring down high blood pressure. Triamterene is a potassium‑sparing diuretic that reduces salt and water while helping your body keep potassium levels from dropping too low.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Maxzide. However, the following is a synopsis of the general guidelines for the use of Maxzide:

• Take Maxzide by mouth, usually once daily.
• Take it at about the same time each day.
• You can take it with or without food.
• Do not increase your dose or take more often than your doctor says.
• If it upsets your stomach, taking it with food may help.
• Continue taking it even if you feel well unless your doctor tells you to stop.

Some mild or common side effects of Maxzide seen in clinical trials as compared to placebo include:

• Increased urination (more frequent peeing)
• Dizziness or lightheadedness, especially when standing up
• Dry mouth
• Headache
• Upset stomach or nausea
• Fatigue or drowsiness
• Rash

Some individuals may experience serious side effects while using Maxzide. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of high potassium (hyperkalemia): muscle weakness, fast or irregular heartbeat, confused feeling
• Severe dehydration signs such as very dry mouth, very dark urine, and feeling faint
• Allergic reactions: hives, trouble breathing, swelling of the face or throat
• Changes in vision or eye pain
• Severe stomach pain or signs of pancreatitis
• Signs of kidney problems: lower back pain, trouble urinating
• Irregular heartbeat

These are not all of the possible side effects of Maxzide. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Maxzide, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Kidney problems or kidney disease
• High potassium levels (hyperkalemia)
• Heart disease
• Diabetes or high blood sugar
• Liver disease
• History of electrolyte imbalance
• A sulfa allergy
• History of kidney stones or parathyroid disease
• Conditions like gout or lupus

Boxed Warning

Maxzide has a boxed warning for the risk of hyperkalemia (high potassium levels). Doctors monitor potassium levels regularly because severe hyperkalemia can be dangerous.

• High potassium levels (hyperkalemia)
• Very low or no urine output (anuria)
• Severe kidney impairment
• A known allergy to triamterene, hydrochlorothiazide, or other sulfa drugs
• You are taking other potassium‑sparing diuretics like spironolactone or amiloride, or potassium supplements, unless directed by a doctor

You may start to notice changes in urination and some blood pressure lowering within a few hours of taking Maxzide, but the full effect on blood pressure may take several weeks. Follow your doctor’s appointment schedule for monitoring.

When Maxzide is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Lithium (can increase toxicity)
• Dofetilide
• Potassium supplements or salt substitutes containing potassium
• Other diuretics or antihypertensive drugs
• NSAIDs (like ibuprofen)
• Certain diabetes medications

Maxzide is available in fixed‑dose combinations of hydrochlorothiazide and triamterene, such as Maxzide 25mg formulations. Your doctor will prescribe the dose suitable for your condition.

Store Maxzide at room temperature away from moisture and heat. Keep it out of reach of children and pets.

Maxzide is marketed by various pharmaceutical companies under the brand names Maxzide and Dyazide. Specific manufacturers can vary by product and region.

Yes, generic versions containing hydrochlorothiazide and triamterene are available and may be prescribed.

Do not stop taking Maxzide without talking to your doctor. Abruptly stopping may raise your blood pressure or worsen fluid retention. Your doctor will guide a safe plan to stop or switch medications.

Maxzide is generally not recommended during pregnancy because it can affect fluid and electrolyte balance, potentially causing complications for both the mother and the developing baby. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Maxzide and its components may pass into breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.