Metaglipand/or alternativesChemical Ingredient: Glipizide/Metformin Hydrochloride
What is a generic medication?
Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.
No brand name is available for Metaglip 2.5/500mg.
No brand name is available for Metaglip 2.5/500mg.
- Manufactured by A US FDA approved Generic Manufacturer
- Product of United States • Shipped from United States
- Prescription Required
This product is currently unavailable
Metaglip Drug Information
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You can easily place an order on our website in under 5 minutes. First you need to set up an account with us, create a payment method, and send us your prescriptions. Alternatively, you can order by downloading our order form or by placing an order over the phone. Delivery can take approximately 2 weeks to North America, and 4 weeks to other countries.
Glipizide/Metformin Hydrochloride Drug Information
This diabetes medication is a combination of 2 drugs (glipizide and metformin). Metaglip is used along with a diet and exercise program to control high blood sugar in patients with type 2 diabetes. Glipizide is a sulfonylurea and works by stimulating the release of your body's natural insulin and by decreasing the amount of sugar that your liver makes. Metformin is a biguanide and works by decreasing the amount of sugar that your liver makes and that your stomach/intestines absorb. Both of these medications work by helping to restore your body's proper response to the insulin you naturally produce. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.
Rarely, too much metformin can build up in the body and cause a serious (sometimes fatal) condition called lactic acidosis. Lactic acidosis is more likely if you are an older adult, if you have kidney or liver disease, dehydration, heart failure, heavy alcohol use, if you have surgery, if you have X-ray or scanning procedures that use iodinated contrast, or if you are using certain drugs. For some conditions, your doctor may tell you to stop taking Metaglip for a short time. Ask your doctor or pharmacist for more details. Stop taking Metaglip and get medical help right away if you have any symptoms of lactic acidosis, such as unusual tiredness, dizziness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, slow/irregular heartbeat, or stomach pain with nausea/vomiting/diarrhea.
How to Use Metaglip
Read the Patient Information Leaflet available from your pharmacist before you start using Metaglip and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take Metaglip by mouth, usually once or twice a day with meals or as directed by your doctor. Drink plenty of fluids while taking Metaglip unless otherwise directed by your doctor. The Dosage of Metaglip is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start Metaglip at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. If you are already taking another diabetes drug (e.g., chlorpropamide), follow your doctor's directions carefully for stopping the old drug and starting this combination medication. Colesevelam can decrease the absorption of glipizide. If you are taking colesevelam, take Metaglip at least 4 hours before taking colesevelam. Use Metaglip regularly in order to get the most benefit from it. Remember to use Metaglip at the same time(s) each day. Inform your doctor if your condition persists or worsens (for example, if you have high/low blood sugar). It may take up to 2 weeks before the full benefit of Metaglip takes effect.
Before taking Metaglip, tell your doctor or pharmacist if you are allergic to glipizide or metformin; or if you have any other allergies. Metaglip may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Metaglip, tell your doctor or pharmacist your medical history,alcohol use, severe breathing problems (e.g., obstructive lung disease, severe asthma), blood problems (e.g., anemia, vitamin B12 deficiency), electrolyte imbalance (hyponatremia), fertility problems (e.g., ovulation problems), kidney disease, certain hormonal conditions (adrenal/pituitary insufficiency, thyroid disease, syndrome of inappropriate antidiuretic hormone-SIADH). Before having surgery or any X-ray/scanning procedure using iodinated contrast, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may need to stop Metaglip for a short time for the surgery/procedure. Ask your doctor or dentist for instructions before your surgery/procedure. You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcohol while taking Metaglip because it can increase the risk of developing hypoglycemia and lactic acidosis. Rarely, alcohol can interact with glipizide and cause a serious reaction (disulfiram-like reaction) with symptoms such as facial flushing, nausea, vomiting, dizziness, or stomach pain. Consult your doctor or pharmacist about using alcohol safely. It may be harder to control your blood sugar when your body is stressed (e.g., due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing. Metaglip may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness. Older adults may be at greater risk for lactic acidosis or low blood sugar while using Metaglip. Metaglip can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using Metaglip. During pregnancy, Metaglip should be used only when clearly needed. Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may substitute insulin for Metaglip during pregnancy. If glipizide is used, it may be switched to insulin at least 2 weeks before the expected delivery date because of glipizide's risk of causing low blood sugar in your newborn. Discuss the risks and benefits with your doctor. Metaglip passes into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
If you miss a dose of Metaglip, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Many drugs can affect your blood sugar, making it harder to control. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your diabetes medication, exercise program, or diet. Beta-blocker medications (e.g., metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs. Check the labels on nonprescription/herbal products carefully. Some products may contain sugar/alcohol and may affect blood sugars. Ask your doctor or pharmacist about using these products safely.
Metaglip Side Effects
What are Metaglip side effects?
Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Metaglip may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Metaglip as a result of an interaction with other medications.
Side Effects of Metaglip
The side effects of Metaglip may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Metaglip. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Metaglip may also occur as a result of an interaction with certain herbal supplements, foods or drinks.
Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Metaglip, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Metaglip.
By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Metaglip, or any other medication, should contact their physician. General information about Metaglip and the side effects associated with Metaglip are described in the following:
Common Metaglip Side Effects
- hypoglycemic disorder
- headache disorder
- upper respiratory infection
- headache disorder
- vitamin B12 deficiency
- abdominal distension
- weight loss
Less Frequent Metaglip Side Effects
- weight gain
- nail disorders
- skin rash
- flu-like symptoms
- acute abdominal pain
Rare or Very Rare Metaglip Side Effects
- porphyria cutanea tarda
- hepatic porphyria
- hemolytic anemia
- aplastic anemia
- thrombocytopenic disorder
- blood dyscrasias
- obstructive hyperbilirubinemia
- hepatic failure
- SIADH syndrome
- abnormal hepatic function tests
- maculopapular rash
- hepatocellular damage
- gastrointestinal hemorrhage
- neutropenic disorder
- hypoglycemic disorder
- lactic acidosis
- megaloblastic anemia
- acute respiratory distress syndrome
- hepatocellular damage
- cholestatic hepatitis
- skin photosensitivity
- pruritus of skin
- skin rash
- acute abdominal pain
- gastrointestinal irritation
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Metaglip when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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