Glynase

The active ingredient in Glynase is glyburide micronized. Glyburide belongs to the sulfonylurea drug class. Sulfonylureas cause your pancreas to secrete insulin, lowering your blood sugar.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Glynase. However, the following is a synopsis of the general guidelines for the use of Glynase:

• Take it with the first meal of the day, if taken once a day.
• You could have an increased risk of low blood sugar (hypoglycemia) and feel extremely hungry, dizzy, angry, confused, worried, or shaky. To correct hypoglycemia quickly, eat or drink something with a high sugar content.
• If you are hypoglycemic, your doctor may prescribe a glucagon injection kit. Ensure that your family or close friends are aware of how to administer this injection in an emergency.
• Stress, illness, surgery, exercise, alcohol consumption, and skipping meals all have an impact on blood sugar levels. Consult your doctor before changing your dose or drug schedule.

The most common side effects of Glynase seen in clinical trials as compared to placebo include:

• Nausea.
• Heartburn.
• Feeling bloated.
• Weight gain.
• Blurred vision.
• Hypoglycemia.

Some individuals may experience serious side effects while using Glynase. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Allergic reactions such as skin rash, hives, trouble breathing, or redness.
• Severe low blood sugar: anxiety, sweating, shaking, confusion, dizziness, weakness, fast heartbeat, feeling hungry, seizures.

These are not all of the possible side effects of Glynase. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Glynase, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Type 1 diabetes.
• Treated with bosentan.
• Diabetic ketoacidosis.
• Hemolytic anemia.
• Enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency).
• Nerve disorders.
• Kidney disease or liver disease.
• Allergy to sulfa drugs.
• Tell your doctor whether you've taken any other oral diabetic medications or used insulin during the last two weeks.
• Glynase PresTab may increase your chance of major heart problems, but untreated diabetes can also harm your heart and other organs. Ask your doctor about the dangers and advantages of this medication.

Hypersensitivity or allergy to sulfa medication.

In nonfasting diabetic patients, the blood glucose-lowering impact lasts up to 24 hours after a single morning dose. However, upon repeated dosing in diabetic individuals, there is no meaningful association between blood medication levels and fasting blood glucose levels.

When Glynase is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Colesevelam.
• Metformin.
• Miconazole.

Glyburide: The usual starting dose is 2.5 mg to 5 mg taken orally once daily with breakfast or the first substantial meal. Your provider will work with you weekly to modify your dose until your blood sugar level is within the target range. The normal maintenance dose is 1.25 mg to 20 mg administered orally once daily or divided into smaller doses twice daily. The maximum daily dosage is 20 mg.

Micronized glyburide (Glynase and its generics): The recommended starting dose is 1.5 mg to 3 mg taken orally once daily with breakfast or the first substantial meal. Your provider will work with you weekly to modify your dose until your blood sugar level is within the target range. The normal maintenance dose is 0.75 mg to 12 mg administered orally once daily or divided into smaller doses twice daily. The maximum daily dosage is 12 mg.

Take the missed dose as soon as you remember, unless it is close to the next scheduled dose. Do not double dose.

Store at room temperature, in a dry place, and keep out of reach of children.

Pfizer is the company that manufactures Glynase.

There are several lower-cost generic name versions available.

Do not start, stop, or change the dose of any drug without checking with your doctor.

If you are or become pregnant, follow your doctor's instructions for using this medication. Controlling diabetes is critical during pregnancy because excessive blood sugar levels can create difficulties for both the mother and the baby. However, you may need to stop taking Glynase PresTab for a short period before your due date.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you. However, it is not advised to breastfeed while taking this medication.