Nexletol

The active ingredient in Nexletol is bempedoic acid. This medication belongs to a group of drugs called adenosine triphosphate-citrate lyase (ACL) inhibitors and is considered to be a lipid-lowering agent. Bempedoic acid in particular is known to be a nonstatin that interrupts the body’s cholesterol-making process by reducing the amount of cholesterol made by your liver and increasing the breakdown of bad cholesterol.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Nexletol. However, the following is a synopsis of the general guidelines for the use of Nexletol:

• Take this medication orally exactly as directed by your physician. It is typically taken once daily.
• It is important to note that taking statins with Nexletol may increase the risk of developing muscle weakness (myopathy).
• Nexletol works as an adjunct to diet and can be used alone or in combination with other LDL-C lowering therapies.

The most common side effects of Nexletol seen in clinical trials as compared to placebo include:

• Upper respiratory tract infection.
• Muscle spasms.
• Bronchitis.
• Back pain.
• Stomach pain.
• Anemia.
• Liver problems due to increased liver enzymes.
• Kidney problems.

Some individuals may experience serious side effects while using Nexletol. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Severe allergic reaction - hives, swelling, itching, joint pain.
• Increased blood uric acid level (hyperuricemia).
• Increased risk of tendon rupture in patients over 60 years of age as well as patients who have renal failure.

These are not all of the possible side effects of Nexletol. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Nexletol, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Gout.
• Tendon problems.
• Liver problems.
• Kidney problems.
• Anemia.

• Previous hypersensitivity/allergic reaction to bempedoic acid or any of the excipients.
• Avoid Nexletol in patients who have a history of tendon disorders or tendon rupture.

Nexletol will begin lowering cholesterol levels right away. You won't be able to feel it decreasing your cholesterol, but your provider will check your cholesterol levels around 8 weeks after you start treatment.

When Nexletol is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Cholesterol-lowering medications (simvastatin, pravastatin).
• Antibiotics (fluoroquinolone).

Nexletol is available in the following dosage forms:

• Oral tablet - 180 mg.

Store this medication at room temperature and keep it out of reach of children.

Esperion Therapeutics, INC is the pharmaceutical company that manufactures Nexletol.

There are lower-cost generics available of the brand name Nexletol.

Do not stop or adjust your use of this medication without first consulting your doctor.

It is not known whether Nexletol is safe to take while pregnant and generally should be avoided. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is unknown if Nexletol passes into breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.