Qulipta

The active ingredient in Qulipta is atogepant. Atogepant is a calcitonin gene-related peptide or CGRP receptor antagonist. It works by blocking the CGRP chemical from producing pain and inflammation.

Qulipta belongs to the same drug class as another medication known as Ubrelvy. But unlike Ubrelvy, Qulipta has approval for use in preventing migraine attacks from happening in the first place. As a result, it can provide long-lasting symptom relief for those who experience chronic migraines. Studies looking at the effect of Qulipta in those with migraine headaches found a decrease in their monthly migraine days and acute headache medication use days (such as Tylenol and Triptans) from baseline over a 12-week period.

If desired, Qulipta may also be used for the preventative treatment of episodic migraines or those that occur infrequently.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Qulipta. However, the following is a synopsis of the general guidelines for the use of Qulipta:

• Typically, Qulipta is taken once a day with or without food.
• Use exactly as prescribed. Do not exceed the recommended dose or duration of use.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

The most common side effects of Qulipta seen in clinical trials as compared to placebo include:

• Nausea
• Constipation
• Fatigue
• Somnolence or sleepiness

Some individuals may experience serious side effects while using Qulipta. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of anaphylaxis or a severe allergic reaction such as trouble breathing, hives, rash, or swelling of the face, lips, and tongue

These are not all of the possible side effects of Qulipta. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Qulipta, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Kidney problems
• Are on dialysis
• Liver impairment
• Are pregnant or plan to become pregnant
• Are breastfeeding or plan to breastfeed

Do not use Qulipta if you have an allergy or hypersensitivity to atogepant or any of the inactive ingredients in this product.

In studies looking at the efficacy of Qulipta, most study participants saw some benefit at the 1 to 4-week mark for their migraine headaches. However, everyone is different and some may not notice a difference until after this period.

When Qulipta is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Strong CYP3A4 inhibitors (itraconazole, clarithromycin)
• CYP3A4 inducers (rifampin)
• OATP inhibitors (topiramate)

Qulipta tablets are available in the following strengths:

• 10 mg
• 30 mg
• 60 mg

Qulipta should be stored at room temperature away from light and out of reach of children.

Qulipta is manufactured by the pharmaceutical company AbbVie Inc.

Currently, there is no generic available for Qulipta.

Consult your doctor or pharmacist before starting, stopping, or changing medications while taking Qulipta.

It is unknown if Qulipta can cause harm to your unborn child. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is unknown if Qulipta can pass into the breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.