Ubrelvy

The active ingredient in Ubrelvy is ubrogepant. Ubrogepant is a calcitonin gene-related peptide (CGRP) that is indicated for the acute treatment of migraine. It works by acting as a receptor antagonist to prevent CGRP from binding and producing pain signals. With this mechanism of action, users can find relief from severe headache pain seen in migraine attacks. It may be used if triptans (a common migraine treatment) cannot be used or past trials offered little to no benefit.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Ubrelvy. However, the following is a synopsis of the general guidelines for the use of Ubrelvy:

• Use exactly as prescribed. Do not exceed the maximum dose of 200mg in 24 hours.
• Ubrelvy should be taken by mouth with or without food at the first sign of a migraine attack. If the first dose did not provide sufficient relief, a second dose may be taken 2 hours after the first dose.
• Do not take Ubrelvy with grapefruit juice.
• If you have liver or renal impairment, you may require a dose adjustment. Consult your healthcare provider before use.

The most common side effects of Ubrelvy seen in clinical trials include:

• Nausea
• Somnolence or sleepiness
• Dry mouth

Some individuals may experience serious side effects while using Ubrelvy. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of an allergic reaction such as difficulty breathing, rash, or swelling of the face, mouth, tongue, or throat

These are not all of the possible side effects of Ubrelvy. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Ubrelvy, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Kidney problems
• Liver problems
• Are pregnant or plan to become pregnant
• Are breastfeeding or plan to breastfeed

Do not use Ubrelvy if you have:

• Concomitant use of strong CYP3A4 inducers or inhibitors
• An allergy to ubrogepant or any of the other inactive ingredients found in Ubrelvy listed on the package insert

Ubrelvy will typically start to work soon after taking the dose. However, everyone is different and some may not feel a difference until an hour later.

When Ubrelvy is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Ketoconazole
• Itraconazole
• Clarithromycin
• Verapamil
• Cyclosporine
• Ciprofloxacin
• Fluconazole
• Fluvoxamine
• Rifampin
• Phenytoin
• Barbiturates
• St. John’s Wort
• BCRP inducers or P-gp inhibitors such as quinidine, carvedilol, eltrombopag, or curcumin

Ubrelvy is available in the following dosage forms and strengths:

• 50 mg tablets
• 100 mg tablets

Ubrelvy should be stored at room temperature, away from light, and out of reach of children.

Ubrelvy is manufactured by Allergan, a pharmaceutical company under AbbVie.

There are currently no generic versions of the brand name Ubrelvy.

Consult your doctor or pharmacist before starting, stopping, or changing medications while taking Ubrelvy.

Based on animal studies, Ubrelvy may cause harm to your unborn child. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is unknown if Ubrelvy can pass into the breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.