Santyl

(Collagenase)

Santyl (collagenase) is a brand-name, topical enzyme medication that removes dead tissue while also promoting wound healing and wound care as well as promoting healing of skin ulcers and burns. This collagenase Santyl ointment is approved for use in adults and should be applied to the skin only once per day. Side effects are uncommon, but you may experience skin redness around the wound. Santyl (collagenase) is also available as a generic drug, such as collagenase, and collagenase clostridium histolyticum.

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Brand Versions

Santyl Prescription Required

Strength
250unit/g
Country
Canada
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Marketed as Collegenase Santyl in Canada

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Important information about Santyl

How does Santyl work?

The active ingredient in Santyl is collagenase. The mechanism of action for Santyl (collagenase) is an enzyme (protein) that degrades collagen in damaged or dead skin. This permits new, healthy skin to develop in its place, promoting wound healing. It belongs to the enzymatic debriding agent drug class.

How do you use Santyl?

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Santyl. However, the following is a synopsis of the general guidelines for the use of Santyl:

  • Wash your hands before and after using Santyl.
  • Follow your medical provider's recommendations for cleaning the skin wound and caring for the wound dressing. Use a gauze pad.
  • Santyl is typically administered once daily. If the treated area becomes contaminated, clean it and reapply the ointment.
  • Do not share Santyl with anyone, even if they have the same symptoms as you.
  • Santyl's enzymes may raise your risk of infection in the bloodstream. If you develop a fever, chills, rapid heartbeats, nausea, vomiting, or diarrhea, or if you feel lightheaded or disoriented, contact your doctor immediately.

What are the side effects of Santyl?

The most common side effects of Santyl seen in clinical trials as compared to placebo include:

  • Skin redness around the affected wound area.

Some individuals may experience serious side effects while using Santyl. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Allergic reactions such as skin rash, itching, hives, swelling of the face, lips, tongue, trouble breathing, or throat.

These are not all of the possible side effects of Santyl. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

What are the warnings or precautions for Santyl?

Before starting Santyl, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

  • Allergies towards Santyl.
  • It is advised to monitor patients for the possibility of systemic bacterial infections; debriding enzymes may increase the risk of bacteremia.
  • May cause slight transient erythema in surrounding tissues.

Are there any contraindications with Santyl?

Santyl is not recommended for patients who have exhibited local or systemic hypersensitivity to collagenase.

How long does it take Santyl to work?

In a clinical investigation, half of those who used collagenase ointments such as Santyl (collagenase) had their wounds healed within 6 weeks. In comparison, half of those who used a placebo saw their wounds heal within 8 weeks. However, the time it takes for Santyl (collagenase) to work is determined by your wound and your body's healing rate.

What interacts with Santyl?

When Santyl is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Silver nitrate is applied topically.
  • Silver sulfadiazine topical.
  • Topical applications that include silver and thimerosal.
  • Antiseptic skin products (especially those containing heavy metals such as lead, mercury, and silver).

What doses of Santyl are available?

Santyl (collagenase) is normally given directly to the afflicted area once daily. If your prescriber specifies, you may need to apply it more frequently if the dressing over the affected area becomes soiled.

How do I store Santyl?

Store at room temperature and keep out of reach of children.

Which pharmaceutical company manufactures Santyl?

Smith & Nephew is the company that manufactures Santyl.

Is there a generic version of Santyl?

There are no lower-cost generics available of Santyl.

How do I stop taking Santyl?

Santyl must be applied at least daily or more often if the dressing becomes saturated or soiled (eg incontinence). The collagenase enzymes are short-acting. Discontinue Santyl usage when the wound bed is free of necrotic tissue and granulation tissue is well-established

Can Santyl be used if I am pregnant?

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Can Santyl be used if I am breast feeding?

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.

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Important information about buying Santyl from UniversalDrugstore™

What happens after I place my order for Santyl with Universal Drugstore?

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

How long does it take to process and deliver my order for Santyl?

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Can I track my order of Santyl?

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

What should I do if there is an issue with my order for Santyl?

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

How is my medication packaged to ensure privacy and safety?

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Does Universal Drugstore ship medications that require refrigeration or special handling?

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

What are the shipping costs, and does Universal Drugstore offer free delivery?

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Does Universal Drugstore accept Medicare or Medicaid for prescriptions?

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Can I use private health insurance to cover my prescription from Universal Drugstore?

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Unievrsal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

How secure is my payment information when ordering from Universal Drugstore?

We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.

Can I order a generic alternative to Santyl?

Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

Do I need a prescription to order Santyl?

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription.

Can I order multiple medications at once?

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Can I refill my prescription through Universal Drugstore?

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Does Universal Drugstore offer discounts or price matching?

Yes! We offer:

  • Up to 80% savings on medications
  • Price match guarantee – we’ll match competitor pricing on qualifying medications
  • 10% off your first order for new customers

How can I contact Universal Drugstore for additional support?

We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.

Important

The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.