Buy Sinemet Online

(Levodopa/Carbidopa)

The active ingredient in Sinemet is carbidopa/levodopa. Levodopa belongs to a class of medications called central nervous system agents. It works by being converted to dopamine in the brain. Carbidopa is in a class of drugs called decarboxylase inhibitors. It prevents levodopa from being broken down before it reaches the brain.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Sinemet. However, the following is a synopsis of the general guidelines for the use of Sinemet:

• Take this medication exactly as directed by your physician. It is typically taken by mouth 3 times daily.
• Before having any laboratory tests done, tell your doctor and the laboratory personnel that you are taking this medication.

The most common side effects of Sinemet include:

• Dyskinesia (involuntary movements).
• Headache.
• Feeling light-headed.
• Somnolence (drowsiness).
• Urinary tract infection.
• Sudden sleep onset episodes during daily activities.
• Dry mouth.
• Nausea.
• Constipation.

Some individuals may experience serious side effects while using Sinemet. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Severe allergic reaction - swelling, hives, itching.
• Worsening of tremors.
• Severe or ongoing vomiting or diarrhea.
• Hypertension (high blood pressure).
• Hallucinations and changes in behavior and thinking, such as confusion, paranoia, delusions, aggressive behavior, and trouble sleeping.
• Increased sexual urges, excessive eating or spending, and/or other intense urges that could harm yourself or others.
• Neuroleptic malignant syndrome (NMS) - a nervous system reaction consisting of hypotension (low blood pressure), stiff muscles, high fever, sweating, confusion, fast heartbeats.

These are not all of the possible adverse reactions of Sinemet. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Sinemet, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Heart disease including arrhythmias.
• Hypertension (high blood pressure).
• Liver disease.
• Kidney disease.
• Endocrine disorder.
• Asthma.
• Chronic obstructive pulmonary disease (COPD).
• Peptic ulcer.
• Unusual skin lumps or moles which have not been examined by your doctor.
• Skin cancer (melanoma).
• Dyskinesia.
• Open-angle glaucoma.
• Psychosis.

• Previous hypersensitivity/allergic reaction to any component of this drug.
• Patients with narrow-angle glaucoma.
• Taking nonselective monoamine oxidase inhibitors (MAOIs).

The short-acting (immediate-release) formulation takes effect within about 20 to 50 minutes. The long-acting (extended-release) formulation begins to work closer to the 50-minute timeframe.

When Sinemet is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Monoamine oxidase inhibitors (MAOIs) within the past 14 days (phenelzine).
• Selective monoamine oxidase B (MAO-B) inhibitors (selegiline).
• Medications for high blood pressure.
• Tricyclic antidepressants (amitriptyline, nortriptyline).
• Antipsychotics (chlorpromazine, risperidone).
• Isoniazid.
• Medications to control seizures (phenytoin).
• Medications for chest pain (papaverine).
• Tetrabenazine.
• Iron supplements or other multivitamins with iron salts.
• Metoclopramide.
• Medications that cause sleepiness.

The doses of levodopa/carbidopa include:

• Extended-release oral capsules - 23.75 mg/95 mg, 36.25 mg/145 mg, 48.75 mg/195 mg, 61.25 mg/245 mg, 25 mg/100 mg, 50 mg/200 mg.
• Oral tablets - 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg.
• Orally disintegrating tablets - 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg.

Store this medication at room temperature and keep out of reach of children.

Merck is the pharmaceutical company that manufactures Sinemet.

There are lower-cost generics available for the brand name Sinemet.

Do not stop or adjust your use of this medication without first consulting with your doctor.

It is unknown if or how Sinemet could affect pregnancy or harm an unborn baby. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Levodopa, one of the components of Sinemet is known to pass into human milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.