Sinemet CR(Levodopa/Carbidopa CR, Levodopa/Carbidopa ER)
Marketed as Half Sinemet CR in United Kingdom
What is a generic medication?
Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.
Sinemet CR Drug Information
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Sinemet CR Overview
This combination medication is used to treat symptoms of Parkinson's disease or Parkinson-like symptoms (such as shakiness, stiffness, difficulty moving). Parkinson's disease is thought to be caused by too little of a naturally occurring substance (dopamine) in the brain. Levodopa changes into dopamine in the brain, helping to control movement. Carbidopa prevents the breakdown of levodopa in the bloodstream so more levodopa can enter the brain. Carbidopa can also reduce some of levodopa's side effects such as nausea and vomiting.
How to Use Sinemet CR
Take Sinemet CR by mouth with or without food as directed by your doctor, usually 2 to 3 times a day. Doses are usually taken 4 to 8 hours apart while awake. Do not crush or chew Sinemet CR. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Taking Sinemet CR with food may help to decrease nausea. It is best to avoid a high-protein diet (it decreases the amount of levodopa that your body takes in) during treatment, unless directed otherwise by your doctor. Separate your dose of Sinemet CR by as many hours as possible from any iron supplements or products containing iron (such as multivitamins with minerals) you may take. Iron can reduce the amount of Sinemet CR absorbed by the body. Consult your doctor or pharmacist for more details. The Dosage of Sinemet CR is based on your medical condition and response to treatment. If you are switching from immediate-release levodopa/carbidopa to Sinemet CR, your doctor may slightly increase your dose of Sinemet CR to get the same response. Sinemet CR may take a little longer to work in the morning than the immediate-release medication because it is absorbed more slowly. Let your doctor know if this becomes a problem. Use Sinemet CR regularly to get the most benefit from it. To help you remember, take it at the same times each day. Your doctor may also prescribe immediate-release carbidopa/levodopa or carbidopa alone to be taken with Sinemet CR. Make sure you understand your dosing schedule and follow it closely. Some patients may experience a "wearing-off" (worsening of symptoms) before the next dose is due. An "on-off" effect might also occur, in which sudden short periods of stiffness occur. If these effects occur, contact your doctor for possible dose adjustments that may help to lessen this effect. Do not stop taking Sinemet CR without consulting your doctor. Some conditions may become worse when Sinemet CR is suddenly stopped. Also, if you suddenly stop using Sinemet CR, you may have withdrawal symptoms (such as anxiety, depression, confusion, fever, muscle stiffness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used Sinemet CR for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal. Tell your doctor if your condition does not improve or if it worsens.
Sinemet CR Precautions
Before taking Sinemet CR, tell your doctor or pharmacist if you are allergic to carbidopa or levodopa; or if you have any other allergies. Sinemet CR may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Sinemet CR, tell your doctor or pharmacist your medical history,liver disease, glaucoma, breathing problems (such as asthma), heart disease (such as heart attack, irregular heartbeat), kidney disease, stomach/intestinal ulcer, mental/mood disorders (such as depression, schizophrenia), blood disorders, seizures, sleep disorders. Sinemet CR may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). See also Side Effects section. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, Sinemet CR should be used only when clearly needed. Discuss the risks and benefits with your doctor. Levodopa passes into breast milk in small amounts and may affect how much milk you make. It is unknown if carbidopa passes into breast milk. Consult your doctor before breast-feeding.
Sinemet CR Misdose
If you miss a dose of Sinemet CR, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Sinemet CR Interactions
See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.antipsychotic drugs (such as chlorpromazine, haloperidol, thioridazine), certain drugs used to treat high blood pressure (such as methyldopa). Taking MAO inhibitors with Sinemet CR may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, tranylcypromine) during treatment with Sinemet CR. Most MAO inhibitors should also not be taken for two weeks before treatment with Sinemet CR. However, certain MAO inhibitors (rasagiline, safinamide, selegiline) may be used with careful monitoring by your doctor. Ask your doctor when to start or stop taking Sinemet CR. Sinemet CR may interfere with certain laboratory tests (including urine catecholamine/glucose/ketone tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Sinemet CR.
Sinemet CR Side Effects
Dizziness, lightheadedness, nausea, vomiting, loss of appetite, trouble sleeping, unusual dreams, or headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Sinemet CR may cause saliva, urine, or sweat to turn a dark color. This effect is harmless, but your clothes may be stained. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that Sinemet CR has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using Sinemet CR do not have serious side effects. Some people taking Sinemet CR have fallen asleep suddenly during their usual daily activities (such as talking on the phone, driving). In some cases, sleep occurred without any feelings of drowsiness beforehand. This sleep effect may occur anytime during treatment with Sinemet CR even if you have used Sinemet CR for a long time. If you experience increased sleepiness or fall asleep during the day, do not drive or do other possibly dangerous activities until you have discussed this effect with your doctor. Your risk of this sleep effect is increased by using alcohol or other medications that can make you drowsy. See also Precautions section. Tell your doctor right away if you have any serious side effects,new/worsening movements you can't control/spasms, greatly increased eye blinking/twitching, fainting, vision changes (such as blurred vision, double vision), eye pain, severe stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds, mental/mood changes (such as confusion, agitation, hallucinations), signs of infection (such as sore throat that doesn't go away), easy bleeding/bruising, unusual tiredness, tingling of the hands/feet, unusual strong urges (such as increased gambling, increased sexual urges). Get medical help right away if you have any very serious side effects,chest pain. Abruptly stopping or reducing the dose of Sinemet CR may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS).fever, unusual muscle stiffness, severe confusion, sweating, fast/irregular heartbeat, rapid breathing. A very serious allergic reaction to Sinemet CR is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Sinemet CR Storage
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Sinemet CR when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
IMPORTANT DISCLAIMER: All medical content is supplied by a third-party company who is independent from this web site. As such, this web site cannot guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdictions depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability.