Vascepa

The active ingredient in Vascepa is icosapent ethyl. In the body, icosapent ethyl is converted into its active form eicosapentaenoic acid (EPA) which is a type of omega-3 fatty acid. EPA increases the removal of lipids, decreases their production, and prevents them from being secreted into the blood. As a result, triglyceride levels in the blood will decrease.

EPA has also been demonstrated to lower the risk of cardiovascular events like myocardial infarction (heart attacks). However, the mechanism of action behind this effect of icosapent ethyl remains unclear.

Fish oil is another source of EPA that is commonly used as a dietary supplement by many. Although it is widely available OTC, it contains a mixture of omega-3 fatty acids in varying combinations while Vascepa has FDA approval and contains pure EPA in its ethyl ester form.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Vascepa. However, the following is a synopsis of the general guidelines for the use of Vascepa:

• Typically, Vascepa is taken by mouth twice a day with food.
• Use exactly as prescribed. Do not exceed the recommended dose or duration of use.
• Swallow Vascepa capsules whole. Do not crush, break, dissolve, or chew capsules.
• Before starting Vascepa, your doctor may also put you on a risk-reduction diet that is low in saturated fat, cholesterol, carbohydrates, and added sugars if you are at increased risk. Stay on this diet while using Vascepa.
• Your healthcare provider will send you for blood work to monitor your lipid and cholesterol levels.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

The most common side effects of Vascepa seen in clinical trials as compared to placebo include:

• Muscle pain
• Arthralgia (joint pain)
• Throat and mouth pain
• Swelling in lower legs and hands
• Constipation
• Gout

Some individuals may experience serious side effects while using Vascepa. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of atrial fibrillation or atrial flutter such as chest discomfort, fast or irregular heart rhythm, shortness of breath, or dizziness
• Signs of an allergic reaction such as difficulty breathing, hives, rash, itch, or swelling of the face, tongue, or eyes
• Using Vascepa alongside certain medications that affect blood clotting can increase the incidence and risk of bleeding. Report any unusual bruising or bleeding events right away.

These are not all of the possible side effects of Vascepa. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Vascepa, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Diabetes mellitus
• Hypothyroidism
• Liver problems
• Pancreas problems
• An allergy to fish or shellfish
• Are pregnant or planning to become pregnant
• Are breastfeeding or planning to breastfeed

Do not Vascepa if you have an allergy to any active or inactive ingredients in the product.

Vascepa does not work right away. Even though you will not feel the effects of Vascepa, it is important you take it regularly. Improvement in triglyceride levels may be seen after several weeks of regular use.

When Vascepa is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Blood thinners such as:

--- Anticoagulants

--- Warfarin

--- Aspirin

--- Clopidogrel

Vascepa capsules are available in the following strengths:

• 0.5 g
• 1 g

Vascepa should be stored at room temperature away from light and out of reach of children.

Vascepa is manufactured by the pharmaceutical company Amarin Pharma, Inc.

Yes, a generic version of the brand name Vascepa is available.

Consult your doctor or pharmacist before starting, stopping, or changing medications while taking Vascepa.

It is unknown if Vascepa can harm the unborn child. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Vascepa can pass into the breast milk and may harm the breastfeeding infant. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.