Vyzulta

The active ingredient in Vyzulta is latanoprostene bunod. Latanoprostene bunod is a prostaglandin analog that helps to decrease the IOP or intraocular pressure (eye pressure). Too high of a pressure can damage your optic nerve and lead to permanent vision changes. Latanoprostene bunod is similar to latanoprost in that they are both prostaglandin analogs. However, latanoprostene bunod can lower the IOP in 2 ways, unlike latanoprost, making it more effective.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Vyzulta. However, the following is a synopsis of the general guidelines for the use of Vyzulta:

• Typically, you will use one drop of Vyzulta in the affected eye once daily at night.
• Use exactly as prescribed. Do not exceed the recommended dose or duration of use.
• If you wear contact lenses, remove them before using Vyzulta. If 15 minutes have passed since using Vyzulta, you may wear your contact lenses.
• If you use other drops at the same time as Vyzulta, wait 5 minutes between using each of them.
• When using the drops, do not touch the tip of the dropper with your fingers or the eye to avoid contamination and any eye infections.
• Vyzulta works best at night but if you miss a dose, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed one.

The most common side effects of Vyzulta seen in clinical trials include:

• Eye irritation.
• Eye pain.
• Conjunctival hyperemia or red eyes.
• Temporary increase in lash growth and the number of eyelashes.

Some individuals may experience serious side effects while using Vyzulta. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of bacterial keratitis or other eye infections due to using a contaminated solution. Symptoms can include pus or discharge and eye pain. Other symptoms may include photophobia or sensitivity to light and intense eye pain.
• Vision changes.
• Signs of an allergic reaction such as red, itchy eyes, burning sensation, excessive watery discharge, or swelling of the eye area.
• Concerns about changes in the skin around the eye area, especially eyelid skin darkening.
• Darkening of the iris or the colored part of the eye. Stopping Vyzulta can reverse the increase in brown pigmentation.

These are not all of the possible side effects of Vyzulta. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Vyzulta, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• A current presentation or history of inflammation in the eye, including iritis or uveitis
• Photophobia or eyes that are sensitive to light
• Macular edema
• Aphakia (no lens in your eye) or other lens problems
• Wear contact lenses
• Are pregnant or plan to become pregnant
• Are breastfeeding or plan to breastfeed

No, there are no contraindications with Vyzulta.

Vyzulta will start to work after the first dose but its effects are not something you will be able to notice. Your healthcare provider will follow up with you to monitor your eye health and see if Vyzulta is right for you.

When Vyzulta is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions.

Vyzulta ophthalmic solution is available in the following strengths:

• Latanoprostene bunod 0.024%

Unopened Vyzulta should be stored in the fridge. Once opened, it can be kept at room temperature for up to 8 weeks. Do not freeze Vyzulta. Protect from light and keep out of reach of children.

Vyzulta is manufactured by the pharmaceutical company Bausch & Lomb.

Currently, there is no generic available for the brand name Vyzulta.

Vyzulta is typically a long-term medication. Consult your doctor or pharmacist before starting, stopping, or changing medications while taking Vyzulta.

It is unknown if Vyzulta can cause harm to your unborn child. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is unknown if Vyzulta can pass into the breastmilk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.