Deplin (L-Methylfolate Calcium)
Deplin is a brand-name prescription medical food that contains l-methylfolate (as l-methylfolate calcium). It is specially formulated to meet the nutritional requirements for neurotransmitter imbalances in the clinical dietary management of depression and schizophrenia. It should be used under medical supervision. It is usually used as an adjunctive treatment of depression with antidepressant medications.
Order Deplin online today and save!
Select your dosage:
- All Strength's
- 7.5mg
- 15mg
brand Versions
Please see generic options below.
L-Methylfolate (generic Deplin)
L-Methyltetrahydrofolate Calcium 7.5mg
Prescription RequiredMarketed as Tetrafol in India
L-Methyltetrahydrofolate Calcium 15mg
Prescription RequiredDon't see what you're looking for? Contact us
Important information about Deplin
How does Deplin work?
The active ingredient in Deplin is l-methylfolate. L-methylfolate is the biologically active form of folate needed for the synthesis of key neurotransmitters involved in mood regulation, including serotonin, norepinephrine, and dopamine. It may support neurotransmitter production in people who have difficulty converting folic acid into its active form due to low activity of the MTHFR enzyme (MTHFR polymorphism). It may also help those with other forms of folate deficiency (low folate levels).
How do you use Deplin?
Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Deplin. However, the following is a synopsis of the general guidelines for the use of Deplin:
It may be taken with or without food.
Use only under medical supervision.
If you are pregnant or nursing, consult your doctor before use.
What are the side effects of Deplin?
There are no known common side effects of Deplin seen in clinical trials as compared to placebo.
Some individuals may experience serious side effects while using Deplin. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:
Life-threatening severe allergic reactions, including swelling, rash, hives, wheezing, or anaphylaxis.
Mask symptoms of vitamin B12 deficiency, which can allow neurological damage to progress undetected.
These are not all of the possible side effects of Deplin. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.
What are the warnings or precautions for Deplin?
Before starting Deplin, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:
Vitamin B12 deficiency risk, because folate-related products may affect how vitamin B12 deficiency is recognized.
Folate conversion issues, because l-methylfolate is not interchangeable with folic acid supplements.
Are there any contraindications with Deplin?
Deplin is contraindicated in patients with known hypersensitivity to any of the components in the product.
How long does it take Deplin to work?
Deplin may be used as an adjunctive therapy for depressive symptoms, and response timing may vary between individuals. Clinical benefit may take several weeks, depending on the condition being treated and the overall treatment plan.
What interacts with Deplin?
When Deplin is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:
Anticonvulsants such as carbamazepine and valproic acid may have decreased levels when taken with l-methylfolate.
Anticonvulsants that lower folate, including carbamazepine, valproic acid, and lamotrigine, may require higher doses of l-methylfolate.
What doses of Deplin are available?
Deplin is available as capsules in the following dosage forms:
7.5 mg.
15 mg.
How do I store Deplin?
It should be stored at room temperature, away from the reach of children or pets.
Which pharmaceutical company manufactures Deplin?
Deplin is distributed by Alfasigma USA, Inc.
Is there a generic version of Deplin?
Yes, it is available from many manufacturers of generic drugs.
How do I stop taking Deplin?
Do not stop using Deplin without talking to your healthcare provider. If you are using it as adjunct therapy for major depressive disorder or as part of dietary management for another condition, your provider can advise whether you should stop immediately or taper based on your overall treatment plan and symptoms.
Can Deplin be used if I am pregnant?
Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.
Can Deplin be used if I am breast feeding?
Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.
Universal Drugstore Loyalty Rewards
Referral Rewards
Earn $50 by referring a friend to Universal Drug Store. $50 for you, and $50 for your friend.
Click to referLoyalty Rewards
Join our loyalty program, and earn loyalty reward points on each purchase to save even more.
Click to joinImportant information about buying Deplin from UniversalDrugstore™
What happens after I place my order for Deplin with Universal Drugstore?
Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.
How long does it take to process and deliver my order for Deplin?
Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.
Can I track my order of Deplin?
Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.
What should I do if there is an issue with my order for Deplin?
Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.
How is my medication packaged to ensure privacy and safety?
All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.
Does Universal Drugstore ship medications that require refrigeration or special handling?
Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.
What are the shipping costs, and does Universal Drugstore offer free delivery?
Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.
Does Universal Drugstore accept Medicare or Medicaid for prescriptions?
Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.
Can I use private health insurance to cover my prescription from Universal Drugstore?
Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.
How secure is my payment information when ordering from Universal Drugstore?
We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.
Can I order a generic alternative to Deplin?
Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.
Do I need a prescription to order Deplin?
If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.
Can I order multiple medications at once?
Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.
Can I refill my prescription through Universal Drugstore?
Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.
Does Universal Drugstore offer discounts or price matching?
Yes! We offer:
- Up to 80% savings on medications
- Price match guarantee – we’ll match competitor pricing on qualifying medications
- 10% off your first order for new customers
How can I contact Universal Drugstore for additional support?
We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.
Related Conditions
Important
The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment.
Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.