Persantine

(Dipyridamole)

The active ingredient in Persantine is dipyridamole. Dipyridamole is an antiplatelet agent, and its mechanism of action involves blocking the uptake of adenosine in platelets, thus preventing platelet aggregation and causing coronary vasodilation. Therefore, the effects of dipyridamole effectively help to reduce blood clots and help blood flow.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Persantine. However, the following is a synopsis of the general guidelines for the use of Persantine:

• The typical dose ranges from 75 mg to 100 mg by mouth four times a day. It's usually taken with Coumadin (warfarin).
• Persantine is also given intravenously (IV), so follow the directions from your healthcare provider, as they will know what is best for you.
• If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Continue taking Persantine as scheduled.

The most common side effects of Persantine include:

• Diarrhea.
• Headache.
• Flushing.
• Rash.
• Stomach pain.
• Lightheadedness.

Some individuals may experience serious side effects while using Persantine. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Allergic reaction. Signs of this adverse reaction include hives, rash, and swelling of the face, lips, or tongue.
• In cases of overdose, aminophylline may be given to reverse the effects.
• Chest pain or tightness in the chest.
• Irregular heartbeat or a fast or slow heart rate.
• Myocardial infarction (heart attack).
• Hypotension (low blood pressure).

These are not all of the possible side effects of Persantine. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Persantine, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Myasthenia gravis.
• Cardiovascular problems, like unstable angina, hypotension (low blood pressure), and recent myocardial infarction (heart attack).
• Liver (hepatic) problems.

Allergy to dipyridamole or any ingredients in Persantine.

The pharmacokinetics of Persantine show it starts working in about 20 minutes and has a half-life of 10 to 12 hours.

When Persantine is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Riociguat.
• Adenosine.
• Medications for myasthenia gravis.
• Antiplatelet and anticoagulant agents like warfarin.
• Theophylline.

Persantine or generic dipyridamole may be available as an oral tablet in strengths of 25 mg, 50 mg, 75 mg, or 100 mg.

Store Persantine at room temperature, away from light and moisture. Keep out of reach of children and pets.

Boehringer-Ingelheim manufactures Persantine.

Yes, there are generic versions of Persantine (dipyridamole) available.

Do not stop taking Persantine without consulting your healthcare provider. Your risk of blood clots may increase if you stop taking Persantine.

Based on limited human data, dipyridamole has a low risk when used in pregnancy. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Based on limited human data, dipyridamole is probably compatible with breastfeeding, but it should be used with caution. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.