Rhofade

(Oxymetazoline Hydrochloride)

Rhofade (oxymetazoline) is a brand-name alpha-1A receptor agonist that treats rosacea-induced face redness. It is a topical cream that contains oxymetazoline 1% which is applied to the face once daily.

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Brand Versions

Rhofade Prescription Required

Strength
1%
Country
United States
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Important information about Rhofade

How does Rhofade work?

The active ingredient in Rhofade is oxymetazoline hydrochloride, which is a topical alpha-adrenoceptor agonist. It acts by compressing blood vessels at the skin's surface, reducing facial redness.

How do you use Rhofade?

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Rhofade. However, the following is a synopsis of the general guidelines for the use of Rhofade:

  • Do not take it by mouth. Topical use medication is intended for use solely on the skin. Avoid using this drug on open wounds or irritated skin. If this medication goes into your eyes, nose, mouth, or vagina, rinse with water.
  • Apply a thin layer, pea-sized amount of Rhofade over the entire face. Do not apply near your eyes or mouth, and wash your hands after using this medication.

What are the side effects of Rhofade?

The most common side effects of Rhofade seen in clinical trials include:

  • Irritation or skin rash (dermatitis) on the area where you applied the cream.
  • Itching.
  • Skin redness.
  • Pain around the application site.
  • Worsening rosacea or pimples.

Some individuals may experience serious side effects while using Rhofade. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Heart problems: severe headaches, nosebleeds, difficulty breathing, irregular pulse, dizziness, feeling faint, and chest pain.
  • Worsening narrow-angle glaucoma: head or eye pain, red eyes, sudden loss of vision, and blurred vision.
  • Allergic reactions: skin rash, itching, hives, and swelling of the cheeks, lips, tongue, or neck.

These are not all of the possible side effects of Rhofade. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

What are the warnings or precautions for Rhofade?

Before starting Rhofade, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

  • If you have an allergy to oxymetazoline, you should not take Rhofade.
  • If you have heart disease, high blood pressure, blood circulation issues, glaucoma, or peripheral vascular disease such as Raynaud's phenomenon, Buerger's disease, scleroderma, or Sjögren's syndrome, see your doctor before using Rhofade.
  • Rhofade is not approved for use by anybody under the age of 18.

Are there any contraindications with Rhofade?

There are no obvious contraindications with Rhofade. However, it is important to let your healthcare provider know your other health condition and what other medications you are taking.

How long does it take Rhofade to work?

Rhofade takes a different amount of time to work for each individual. According to one study, some consumers saw an improvement in their skin as soon as one hour after applying the product. However, for other people, it may take several months to see more obvious results.

What interacts with Rhofade?

When Rhofade is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Beta-blockers, antihypertensives, and cardiac glycosides.
  • Albuterol.
  • Bupropion.
  • Duloxetine.

What doses of Rhofade are available?

Typical dosage for adults - use a pea-sized amount of cream once a day on your entire face, including the forehead, nose, cheeks, and chin. Do not use it on your eyes or lips.

If you miss a dose, take it as soon as you remember. If your next dose is coming up soon, skip the missed dose. Do not use extra medication to make up for the missed dose.

How do I store Rhofade?

Store your Rhofade at room temperature and keep it out of reach of children.

Which pharmaceutical company manufactures Rhofade?

EPI Health LLC is the pharmaceutical manufacturer of Rhofade.

Is there a generic version of Rhofade?

No, there are no generic versions available.

How do I stop taking Rhofade?

Do not stop using Rhofade without talking to your healthcare provider first. They will know what the next best steps are.

Can Rhofade be used if I am pregnant?

It is not known if Rhofade is safe to use while pregnant. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Can Rhofade be used if I am breast feeding?

It is not known if Rhofade is found in breast milk or what effects it may have on your breastfed infant or milk production. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.

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Important information about buying Rhofade from UniversalDrugstore™

What happens after I place my order for Rhofade with Universal Drugstore?

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

How long does it take to process and deliver my order for Rhofade?

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Can I track my order of Rhofade?

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

What should I do if there is an issue with my order for Rhofade?

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

How is my medication packaged to ensure privacy and safety?

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Does Universal Drugstore ship medications that require refrigeration or special handling?

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

What are the shipping costs, and does Universal Drugstore offer free delivery?

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Does Universal Drugstore accept Medicare or Medicaid for prescriptions?

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Can I use private health insurance to cover my prescription from Universal Drugstore?

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Unievrsal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

How secure is my payment information when ordering from Universal Drugstore?

We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.

Can I order a generic alternative to Rhofade?

Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

Do I need a prescription to order Rhofade?

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription.

Can I order multiple medications at once?

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Can I refill my prescription through Universal Drugstore?

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Does Universal Drugstore offer discounts or price matching?

Yes! We offer:

  • Up to 80% savings on medications
  • Price match guarantee – we’ll match competitor pricing on qualifying medications
  • 10% off your first order for new customers

How can I contact Universal Drugstore for additional support?

We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.

Important

The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.