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Buy Synvisc Online
(Hylan G-F 20)

What is Synvisc?

What is Synvisc?

Synvisc is a prescription treatment used to relieve knee pain caused by osteoarthritis of the knee. Osteoarthritis is a condition where the cartilage that cushions the knee joint gradually wears down. This can cause pain, stiffness, and reduced mobility.

Synvisc contains hylan polymers A and B, also known as hylan G-F 20. These substances are similar to hyaluronan, a natural substance found in synovial fluid inside healthy joints. Synovial fluid helps lubricate the knee joint and acts as a shock absorber during movement.

Synvisc is given as an intra-articular injection, meaning it is injected directly into the knee joint by a healthcare professional. The treatment is part of a therapy known as viscosupplementation, which helps improve the quality of synovial fluid in the joint.

This treatment may be recommended when other pain relievers such as acetaminophen, NSAIDs, or physical therapy have not provided enough pain relief.

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Purchase Synvisc from Universal Drugstore today and save!

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Synvisc 
8mg/ml

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Hylan G-F 20 (generic Synvisc)

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Important information about Synvisc

The active ingredient in Synvisc is hylan G-F 20.

Hylan G-F 20 is a form of hyaluronan that is designed to mimic the natural lubricating fluid found in healthy joints. In people with osteoarthritis of the knee, the synovial fluid becomes thinner and less effective.

When Synvisc is injected into the knee joint, it helps restore the cushioning and lubricating properties of the synovial fluid. This can reduce friction between bones, improve joint movement, and provide pain relief.

By improving joint lubrication and shock absorption, Synvisc may help reduce knee pain and improve mobility during daily activities and weight-bearing activities.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Synvisc. However, the following is a synopsis of the general guidelines for the use of Synvisc:

  • Synvisc is administered as an intra-articular injection into the knee joint by a healthcare professional.
  • The injection is given using a sterile syringe under medical supervision.
  • Treatment may consist of a series of injections or a single injection, depending on the formulation.
  • Synvisc-One is designed as a single injection treatment for osteoarthritis of the knee.
  • Other Synvisc treatments may involve multiple injections given several weeks apart.
  • After receiving the injection, patients should avoid strenuous activities and heavy weight-bearing activities for several days.
  • Activities such as jogging, tennis, or heavy lifting should be limited for a short period after the injection.
  • Your healthcare provider will determine the appropriate treatment schedule based on your symptoms and medical history.

Some mild or common side effects of Synvisc seen in clinical trials include:

  • Injection site pain.
  • Swelling in the injected knee.
  • Joint stiffness.
  • Fluid build-up in the knee joint.
  • Mild knee pain or discomfort.

Some individuals may experience serious side effects while using $Drugname. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Severe allergic reactions, including hives or swelling.
  • Severe knee swelling or joint effusion.
  • Signs of joint infection, such as fever, redness, or warmth at the injection site.
  • Severe pain (arthralgia) or inability to move the knee after the injection.

Disclaimer: These are not all of the possible adverse events of Synvisc. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Synvisc, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

  • Allergies to hyaluronan products or egg products.
  • Skin disease or infections near the injection site.
  • Joint infection or inflammation in the knee joint.
  • A history of allergic reactions to injectable medications.

Synvisc should not be used in patients with:

  • Known hypersensitivity to hylan polymers or hyaluronan products.
  • Active joint infection or skin disease at the injection site.

The injection should not be given in areas with active inflammation or infection.

Pain relief from Synvisc may not occur immediately after the injection. Some patients begin to notice improvement in knee pain within several weeks after treatment.

Clinical studies have shown that the benefits may last for several months, depending on the individual patient and the severity of osteoarthritis.

When Synvisc is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • NSAIDs, or non-steroidal anti-inflammatory drugs, are used for pain relief.
  • Acetaminophen or other analgesics are used for osteoarthritis pain.
  • Over-the-counter pain relievers or supplements taken for joint health.

These medications are often used together with Synvisc to help manage osteoarthritis symptoms, but your healthcare provider should review your treatment plan.

Synvisc is available as a sterile injection containing hylan G-F 20.

Typical dosing includes:

  • Synvisc is administered as a series of three intra-articular injections into the knee joint, usually given one week apart.
  • Synvisc-One is administered as a single injection for osteoarthritis of the knee.

The exact dosing schedule will be determined by your healthcare provider. The safety and effectiveness of Synvisc have not been established in patients ≤21 years old or in pregnant or lactating women.

It should be stored at room temperature, away from the reach of children or pets.

Synvisc is manufactured by Genzyme Corporation, a company that is part of Sanofi.

There is currently no direct generic version of Synvisc available. However, other viscosupplementation products containing hyaluronate may be available as alternatives.

Synvisc is not taken daily. It is given as a scheduled injection by a healthcare provider. Once the treatment course is complete, no further doses are required unless your healthcare provider recommends additional injections in the future.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. Your healthcare provider will weigh the potential risks and benefits before recommending treatment during pregnancy.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. Your healthcare provider will recommend the safest treatment option.

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Important information about buying Synvisc from UniversalDrugstore™

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

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Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.

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Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

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The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.