Systane

(Hypromellose)

The active ingredient in Systane is hypromellose. Hypromellose is a polysaccharide that works by lubricating and protecting the eye. It increases the viscosity of the artificial tears to stabilize the tear film and form a moisture barrier on the eye. This results in hydration and dry eye relief.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Systane. However, the following is a synopsis of the general guidelines for the use of Systane:

• The recommended directions for use are to place 1 or 2 drops in the affected eye(s) as needed.
• Do not touch tip of the container to any surface, including your eye. Ensure it is always clean and recap the container after you are done using it.
• Systane may be used during the day and night.
• For external use only.
• Do not use Systane if the gel changes color or becomes cloudy.
• Systane cannot be used while wearing contact lenses. However, you can use Systane before and after wearing contact lenses.
• Systane is not preservative-free. It contains a small amount of sodium perborate.

The most common side effects of Systane seen in clinical trials as compared to placebo include:

• Mild burning or irritation of the eye.
• Temporary blurred vision when first used.
• Redness of the eye.

Some individuals may experience serious side effects while using Systane. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Eye pain.
• Vision changes.
• Severe eye irritation.
• Condition worsens or lasts longer than 72 hours.

These are not all of the possible side effects of Systane. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Systane, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Allergic reaction to any eye drops or eye ointments.
• Glaucoma.
• Under 18 years of age.

• Allergic reaction to any ingredients in the Systane formulation.

Systane will start providing symptom relief as soon as you start using it.

When Systane is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Other eye drops, eye ointments, or ophthalmic medications.

Systane (hypromellose) is available as 0.3% hypromellose.

Inactive ingredients include carbopol 980, phosphonic acid, purified water, sodium perborate, and sorbitol. It may also contain sodium hydroxide to adjust pH.

Store Systane at room temperature, out of reach of children and pets.

Alcon manufactures Systane (hypromellose). Alcon also manufactures other Systane products, such as Systane Complete and Systane Ultra.

Yes, there are generic versions of Systane (hypromellose) available.

There are no withdrawal effects associated with Systane (hypromellose); however, symptoms of dry eye may return if you stop taking it. It is always best to consult your healthcare professional before stopping any medication.

Systane (hypromellose) is likely safe when used in pregnancy. This is because the active ingredient, hypromellose, is pharmacologically inert, and the amount absorbed is negligible when used appropriately. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Systane (hypromellose) is likely safe when used in breastfeeding. This is because the active ingredient, hypromellose, is pharmacologically inert, and the amount absorbed is negligible when used appropriately. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.