Trintellix

The active ingredient in Trintellix is Vortioxetine Hydrobromide. Trintellix (vortioxetine) is an atypical antidepressant. Although it is not fully understood, it appears to work by increasing the action of serotonin in the brain. Serotonin is a neurotransmitter (a type of communication molecule) linked to feelings of happiness and well-being.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Trintellix. However, the following is a synopsis of the general guidelines for the use of Trintellix:

• Take Trintellix exactly as directed by your doctor. Follow the recommendations on your prescription label and read any drug guidelines or instruction sheets. Your doctor may occasionally adjust your dosage.
• You can take Trintellix with or without food.
• If you suddenly stop using Trintellix, you may have withdrawal symptoms. Ask your doctor before discontinuing the medication.

The most common side effects of Trintellix seen in clinical trials as compared to placebo include:

• Nausea.
• Diarrhea.
• Dizziness.
• Dry mouth.
• Vomiting.
• Constipation.
• Excessive gas.
• Abnormal dreams.
• Sexual dysfunction or decreased sex drive.
• Itching.
• Trouble sleeping.
• Eye pain.
• Low sodium level, muscle weakness, fatigue, dizziness, headache, confusion.

Some individuals may experience serious side effects while using Trintellix. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Risk of suicidal thoughts and behaviors
• Symptoms of serotonin syndrome symptoms include rapid heartbeat, perspiration, muscle stiffness or spasms, fever, and confusion.
• Increased risk of hyponatremia symptoms, including hypomania, nausea, vomiting, headaches, memory issues, confusion, muscle weakness or cramping, and low blood pressure.
• Serious bleeding symptoms include dizziness, pale skin, weakness, difficult-to-stop bleeding, persistent bruising, vomiting blood, and black and tarry stools.

These are not all of the possible side effects of Trintellix. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Some people experience the benefits of Trintellix (vortioxetine) within two weeks. However, it may take a month or longer before you notice the full effects of this drug. If you do not observe any changes in your mood after this period, contact your healthcare practitioner. They may consider increasing your Trintellix (vortioxetine) dosage or discussing alternative options with you.

Contraindications are certain health problems or situations in which a person should avoid taking a drug for safety reasons. If you have any of the following conditions or if any of the following apply to you, please notify your healthcare professional because Trintellix (vortioxetine) is not safe for you to consume.

• Taking an MAOI within 21 days of Trintellix (vortioxetine)

Some people experience the benefits of Trintellix (vortioxetine) within two weeks. However, it may take a month or longer before you notice the full effects of this drug. If you do not observe any changes in your mood after this period, contact your healthcare practitioner. They may consider increasing your Trintellix (vortioxetine) dosage or discussing alternative options with you.

When Trintellix is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Any other antidepressant
• Buspirone.
• Fentanyl and tramadol.
• Lithium.
• St. John's wort contains tryptophan (also known as L-tryptophan).
• Warfarin, Coumadin, and Jantoven are blood thinners.
• A diuretic, or "water pill".
• Migraine headache medication (triptans).
• NSAIDs (nonsteroidal anti-inflammatory medicines) include aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
• Carbamazepine and phenytoin are seizure medicines.

The typical starting dosage form is 10 milligrams taken orally once daily. The maximum oral dose is 20 mg per day.

Your Trintellix (vortioxetine) dose will be determined by your other drugs and how you respond to it.

If you miss a dose, take it as soon as possible, but omit it if it's almost time for the following dose. Do not take two doses at the same time.

Store at room temperature, free from moisture and heat.

Takeda Pharmaceuticals America, Inc. manufactures Trintellix in the United States. However, the trademark for Trintellix is owned by H. Lundbeck A/S, and Takeda uses it under license.

There are several lower-cost generics of Trintellix available.

Do not stop taking Trintellix abruptly without consulting your doctor. According to the manufacturer, Trintellix can be abruptly stopped. To reduce the danger of withdrawal symptoms, the dose should be gradually reduced before discontinuing the medicine completely.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

However, Trintellix should not be taken when pregnant as there are major risks to the baby such as after-birth withdrawal symptoms including low blood sugar, tremors, and crying, increased chance of significant lung issues at birth, such as persistent pulmonary hypertension in newborns (PPHN) and heavy bleeding soon after birth.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.

Use is not suggested, and a decision should be made between discontinuing breastfeeding and discontinuing the medicine, taking into account the drug's importance to the mother.