Yohimbine

Yohimbine is available as a prescription drug called yohimbine hydrochloride. Its pharmacology involves blocking the alpha-2 adrenergic receptors, which inhibit neurotransmitters from the presynaptic neuron in the nervous system. This allows for the release of norepinephrine and dopamine, while increasing blood flow to help treat impotence.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Yohimbine. However, the following is a synopsis of the general guidelines for the use of Yohimbine:

• This medication can be taken three times per day.
• Ensure high doses are avoided, as they can lead to toxicity in the body.
• If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose.

The most common side effects of Yohimbine seen in clinical trials as compared to placebo include:

• Headache
• Irritability
• Dizziness
• Skin flushing
• Increase in heart rate
• Anxiety

Some individuals may experience serious side effects while using Yohimbine. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Severe allergic reaction: hives or skin reactions, trouble breathing, and swelling of the face and lips
• Irregular heartbeat or severe tachycardia
• High blood pressure (hypertension) or low blood pressure (hypotension)

These are not all of the possible side effects of Yohimbine. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Yohimbine, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

• Hypersensitivity to this medication
• Blood pressure problems
• Liver disease
• Anxiety
• Kidney disease
• Prostate problems
• Cardiovascular conditions
• Schizophrenia
• Post-traumatic stress disorder (PTSD)
• Pregnancy
• Breastfeeding

• Known allergy to Yohimbine
• Pregnancy

Yohimbine generally takes around 30 to 60 minutes to start working, with its full effects occurring within 1 to 2 hours after taking it.

When Yohimbine is taken with other prescription drugs, over-the-counter medications, vitamins, and dietary supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Linezolid
• Isocarboxazid
• Clonidine
• Stimulants
• Certain herbal supplements
• Opioids
• Antidepressants
• Monoamine oxidase inhibitors
• Antihypertensives

The dosage forms available include oral tablets. The strengths available include 2 mg, 5.4 mg, and 6 mg.

It should be stored at room temperature and away from the reach of children.

The pharmaceutical company that manufactures Yohimbine is Mallinckrodt.

There are lower-cost alternatives to the brand-name Yohimbine.

Before stopping this medication, consult your healthcare provider.

This medication should not be used during pregnancy. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

This medication should not be used during breastfeeding. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.