Zofran ODT

The active ingredient in Zofran ODT is ondansetron. Cancer treatments and general anesthesia may increase the release of serotonin, which can cause you to vomit. Ondansetron is a 5-HT3 receptor antagonist, so the mechanism of action is that it works by blocking serotonin from binding to 5-HT3 receptors. This blocks the effect of serotonin; therefore, it is an effective medication for chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Zofran ODT. However, the following is a synopsis of the general guidelines for the use of Zofran ODT:

• The recommended dose of ondansetron will depend on why you are taking it and your age. Take Zofran ODT as directed by your healthcare provider. The label on your bottle should also tell you how to take it.
• To take Zofran ODT, tear along the perforated lines so you have one tablet separated from the rest of the blister pack. Peel the foil backing to release the tablet. Using dry hands, place the tablet on your tongue. It will dissolve quickly, and you can swallow it as normal. Place the tablet on your tongue. It will dissolve, and you can swallow it as normal.
• If you vomit within one hour of taking the first dose of this medication, you may take the same dose again.
• If you miss a dose and do not feel sick, take the next dose as scheduled. If you miss a dose and feel sick or vomit, take the missed dose as soon as possible.

The most common side effects of Zofran ODT include:

• Headaches.
• Constipation.
• Diarrhea.
• Drowsiness.
• Dizziness.

Some individuals may experience serious side effects while using Zofran ODT. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Allergic reaction. Signs include hives, rash, trouble breathing, or swelling of the face, lips, or tongue.
• Heart rhythm problems (irregular heartbeat), like dizziness, lightheadedness, chest pain, palpitations, and fainting.
• Other heart problems, like myocardial ischemia (poor blood flow to the heart).
• Seizures.
• Eye problems, like blurred vision or temporary blindness.
• Serotonin syndrome. Signs include agitation, confusion, hallucinations, and mood changes.

These are not all of the possible side effects of Zofran ODT. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Zofran ODT, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Allergy to Zofran ODT (ondansetron) or medications similar to it like granisetron.
• Liver disease.
• History of heart problems like congestive heart failure.
• Phenylketonuria (PKU). This is because Zofran ODT contains phenylalanine (a component of aspartame).
• Electrolyte problems, such as low potassium (hypokalemia) or low magnesium (hypomagnesemia).
• Heart rhythm disorders, like long QT syndrome and Torsade de Pointes. Zofran ODT may prolong the QT interval and cause QT prolongation.

• Allergy to any ingredients in Zofran ODT.
• If you are taking apomorphine, a medication used to treat Parkinson’s disease.

Based on its pharmacokinetics, Zofran ODT is well absorbed and will start working in 15-30 minutes.

When Zofran ODT is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Opioids, like tramadol.
• Drugs that are used to treat heart rhythm disorders.
• Drugs that affect serotonin. These include selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptan medications, monoamine oxidase inhibitors (MAOIs), linezolid, methylene blue, drugs that contain tryptophan, and St. John’s Wort. This results in an increased risk of serotonin syndrome.
• Antipsychotics or antidepressants.
• Antibiotics or antifungals.
• Drugs that are used to treat asthma.
• Diuretics.

Zofran ODT comes in two strengths, 4 mg and 8 mg of ondansetron.

Other formulations of Zofran include a tablet and an oral solution.

Store Zofran ODT at room temperature, away from children and pets.

Novartis manufactures Zofran ODT.

Yes, there are generic versions of Zofran ODT.

Take Zofran ODT as prescribed by your healthcare provider. You should not take more doses than your doctor prescribed.

Studies have shown that ondansetron does not increase the chance of birth defects or miscarriage. It is likely compatible in pregnancy. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Studies are limited for ondansetron use while breastfeeding. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.