Protopic Ointment

The active ingredient in Protopic is tacrolimus, which is a topical calcineurin inhibitor. It is not quite clear how this medicine works to treat eczema. However, it is thought to inhibit calcineurin, a protein in the body that helps activate the immune system, such as T-cells. By reducing your immune system’s response, Protopic helps decrease skin inflammation that can cause eczema.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Protopic. However, the following is a synopsis of the general guidelines for the use of Protopic:

• Only use this medicine on the areas of your skin that have eczema.
• Do not take by mouth. Topical medication is intended for use solely on the skin.
• Wash your hands before and after taking Protopic, unless the affected area is on your hands.
• Apply a thin coat to clean, dry skin and rub gently; typically twice daily.
• To prevent your skin from becoming too dry after applying Protopic ointment, you may need to apply a moisturizer, cream, or lotion immediately.
• Bandages should not be used to cover treated skin unless directed by your doctor.
• Do not wash, shower, or swim immediately after applying Protopic ointment.
• Avoid tanning beds, sunlamps, or any ultraviolet lights. Limit sun exposure and be sure to wear sunscreen or protective clothing if you have to go outside.
• Avoid drinking alcohol when taking Protopic. Drinking may cause your skin or face to become flushed, red, and feel hot.

The most common side effects of Protopic include:

• Skin burning.
• Itchiness (pruritus).
• Skin redness.
• Flu-like symptoms.
• Acne.
• Skin tingling.
• Muscle pain.
• Upset stomach.
• Swollen or infected hair follicles.

Some individuals may experience serious side effects while using Protopic. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Serious skin infection symptoms include redness, discomfort, swelling, pus, fever, and blisters.

-Allergic reaction to medication, such as a skin rash or hives.

• Increased risk of skin cancer and lymphoma with long-term use.

These are not all of the possible side effects of Protopic. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Protopic, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you have any of the following that apply:

• Skin cancer (melanoma).

-Bacterial or viral skin infection, such as herpes, cold sores, chicken pox, or shingles.

• Weakened immune system.
• Skin conditions like Netherton’s syndrome.
• Are pregnant, plan on becoming pregnant, or are breastfeeding.

There are no contraindications with Protopic.

Protopic (tacrolimus ointment) normally begins working within the first week of treatment, although it can take up to three weeks for full improvement. If there is no obvious improvement after two weeks, visit a doctor about other treatment options.

When Protopic is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Erythromycin.

Tacrolimus ointment (Protopic) is available in two strengths, 0.03% and 0.01%. The FDA has approved both the 0.03% and 0.01% strengths for adults, although the 0.03% level is only approved for children aged 2 to 15.

Adults and children: Apply a thin layer to the affected skin twice daily.

Store at room temperature and keep out of reach of children.

Astellas Pharma US, Inc. is the company that manufactures Protopic.

There are several lower-cost generic versions available.

To stop Protopic, follow your doctor's instructions and gradually reduce the frequency of application rather than discontinuing abruptly. This reduces the chance of worsening eczema or flare-ups.

It is not known if Protopic is safe to use while pregnant. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is not known if Protopic is safe to use while breastfeeding. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.