Astagraf XL

(Tacrolimus ER)
  • All Strengths

  • 0.5mg

  • 1mg

  • 3mg

  • 5mg

Brand Choices

Astagraf XL 0.5mg

Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Astagraf XL 0.5mg
Astagraf XL 0.5mg

Astagraf XL 0.5mg

Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Prescription required. Manufactured by Astellas Pharma. Product of United Kingdom. Shipped from United Kingdom.

Astagraf XL 1mg

Extended Release Capsules

Marketed as Advagraf in Canada

Astagraf XL 1mg
Astagraf XL 1mg

Astagraf XL 1mg

Extended Release Capsules

Marketed as Advagraf in Canada

Prescription required. Manufactured by Astellas Pharma. Product of Canada. Shipped from Canada.

Advagraf 1mg

Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Advagraf 1mg
Advagraf 1mg

Advagraf 1mg

Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Prescription required. Manufactured by Astellas Pharma. Product of United Kingdom. Shipped from United Kingdom.

Astagraf XL 3mg

Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Astagraf XL 3mg
Astagraf XL 3mg

Astagraf XL 3mg

Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Prescription required. Manufactured by Astellas Pharma. Product of United Kingdom. Shipped from United Kingdom.

Astagraf XL 5mg

Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Astagraf XL 5mg
Astagraf XL 5mg

Astagraf XL 5mg

Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Prescription required. Manufactured by Astellas Pharma. Product of United Kingdom. Shipped from United Kingdom.

Astagraf XL Drug Information

Are you paying too much for Astagraf XL? Save up to 80% when purchasing your prescription drugs from Universal Drugstore. Our prescription service aspires to conveniently provide you with affordable medications at the lowest prices in Canada and internationally.

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Why Buy Astagraf XL from Universal Drugstore?

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How Long Does It Take to Receive My Astagraf XL Order?

You can easily place an order on our website in under 5 minutes. First you need to set up an account with us, create a payment method, and send us your prescriptions. Alternatively, you can order by downloading our order form or by placing an order over the phone. Delivery can take approximately 2 weeks to North America, and 4 weeks to other countries.

  • Astagraf XL Overview

    Tacrolimus is used with other medications to prevent rejection of a kidney, heart, or liver transplant. Astagraf XL belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.

  • Astagraf XL Warnings

    Tacrolimus lowers the body's ability to fight an infection/disease (immunosuppression). This may increase your risk of developing an infection or certain types of cancer (e.g., skin cancer, lymphoma). To reduce the risk of these serious side effects, take Astagraf XL at the lowest effective dose as directed by your doctor. Keep all medical and laboratory appointments.unusual skin changes, change in the appearance/size of moles, unusual growths/lumps, swollen glands, night sweats, unexplained weight loss, signs of infection (e.g., fever, persistent sore throat).

  • How to Use Astagraf XL

    Read the Patient Information Leaflet if available from your pharmacist before you start taking tacrolimus and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take Astagraf XL by mouth with or without food, usually every 12 hours or as directed by your doctor. If you have nausea or an upset stomach, you may take Astagraf XL with food, although this may cause your body to absorb less of the drug. However, you must choose one way (with food or without food) and always take Astagraf XL the same way so that your body always absorbs the same amount of drug. Consult your doctor or pharmacist for more details. If you are taking the capsules, swallow them whole. Do not open or crush the capsules. If you are using the granules, read the manufacturer's Instructions for Use first. Use only non-plastic cups, spoons, or oral syringes when preparing or taking a dose. Do not sprinkle the granules on food. Open up the prescribed number of packets for your dose and mix the granules in a cup with 1 to 2 tablespoons (15 to 30 milliliters) of room temperature water and stir well. Drink the dose immediately. You may use an oral syringe to give the dose. Rinse the cup or syringe with the same amount of water and drink the rinse water to make sure the complete dose is taken. Do not prepare the granule mixture ahead of time. Do not save any of the mixture for later use. Dosage of Astagraf XL is based on your weight, medical condition, blood test results (e.g., tacrolimus trough levels), and response to therapy. Tacrolimus is available in different formulations (such as immediate and extended-release). Do not switch between different forms of tacrolimus without consulting your doctor. Do not increase your dose or take Astagraf XL more often without your doctor's approval. Your condition will not improve any faster and the risk of serious side effects may be increased. Also, do not stop taking Astagraf XL without your doctor's approval. Take Astagraf XL regularly in order to get the most benefit from it. It is important to take all doses on time to keep the amount of medicine in your body at a constant level. Remember to take it at the same times each day. Avoid eating grapefruit or drinking grapefruit juice while being treated with Astagraf XL unless your doctor instructs you otherwise. Grapefruit can increase the amount of certain medications in your bloodstream. Consult your doctor or pharmacist for more details. Since Astagraf XL can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle Astagraf XL or breathe the dust from the capsules. Inform your doctor if your condition worsens.

  • Astagraf XL Precautions

    Before taking tacrolimus, tell your doctor or pharmacist if you are allergic to it; or to other macrolide medications (such as sirolimus); or if you have any other allergies. Astagraf XL may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Astagraf XL, tell your doctor or pharmacist your medical history,mineral imbalances (such as high potassium), kidney disease, any recent/current infections, cancer, liver disease, high blood pressure, diabetes. Tacrolimus may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using tacrolimus,certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using tacrolimus safely. Astagraf XL may increase your risk of developing skin cancer. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tacrolimus can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details. Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). Astagraf XL may increase your potassium levels. Before using potassium supplements or salt substitutes containing potassium, consult your doctor or pharmacist. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of Astagraf XL, especially QT prolongation (see above). Since Astagraf XL can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle Astagraf XL or breathe the dust from the capsules. Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using tacrolimus. Tacrolimus may harm an unborn baby. Men and women using Astagraf XL should ask about reliable forms of birth control before and while using Astagraf XL. If you or your partner become pregnant, talk to your doctor right away about the risks and benefits of Astagraf XL. Do not stop taking Astagraf XL unless directed by your doctor. Astagraf XL passes into breast milk and the effect on a nursing infant is unknown. Discuss the risks and benefits with your doctor before breast-feeding.

  • Astagraf XL Misdose

    If you miss a dose of Astagraf XL, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

  • Astagraf XL Interactions

    See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.aluminum/magnesium antacid, cyclosporine, sirolimus, temsirolimus, ziprasidone, other drugs that may increase the level of potassium in the blood (such as "water pills" including amiloride, spironolactone), other drugs that weaken the immune system/increase the risk of infection (such as natalizumab, rituximab). Other medications can affect the removal of tacrolimus from your body, which may affect how tacrolimus works. Examples include cimetidine, danazol, nefazodone, ethinyl estradiol, methylprednisolone, St. John's wort, azole antifungals (such as itraconazole, voriconazole), HIV and HCV protease inhibitors (such as nelfinavir, ritonavir, boceprevir, telaprevir), rifamycins (such as rifampin, rifabutin), certain anti-seizure drugs (such as phenobarbital, phenytoin), among others.

  • Astagraf XL Side Effects

    What are Astagraf XL side effects?

    Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Astagraf XL may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Astagraf XL as a result of an interaction with other medications.

    Side Effects of Astagraf XL

    The side effects of Astagraf XL may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Astagraf XL. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Astagraf XL may also occur as a result of an interaction with certain herbal supplements, foods or drinks.

    Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Astagraf XL, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Astagraf XL.

    By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Astagraf XL, or any other medication, should contact their physician. General information about Astagraf XL and the side effects associated with Astagraf XL are described in the following:

    Common Astagraf XL Side Effects

    Severe

    • infection
    • hypomagnesemia
    • hyperkalemia
    • anemia
    • leukopenia
    • blood dyscrasias
    • CNS toxicity
    • pleural effusions
    • nephrotoxicity
    • seizure disorder
    • insomnia
    • hyperglycemia
    • kidney disease with reduction in GFR

    Less Severe

    • acute confusion
    • symptoms of anxiety
    • nightmares
    • agitation
    • depression
    • gastrointestinal irritation
    • constipation
    • pruritus of skin
    • hallucinations
    • dizziness
    • general weakness
    • tremor
    • skin rash
    • peripheral edema
    • anorexia
    • headache disorder
    • nausea
    • vomiting
    • diarrhea
    • nervousness
    • diabetes mellitus

    Less Frequent Astagraf XL Side Effects

    Severe

    • hypertension
    • cardiomyopathy
    • osteoporosis
    • hypokalemia
    • dyspnea
    • hypercortisolism
    • fungal infection

    Less Severe

    • hypertriglyceridemia
    • hyperlipidemia
    • visual changes
    • tinnitus
    • cramps
    • hyperhidrosis
    • paresthesia
    • chest pain
    • urinary tract infection
    • pain
    • dyspepsia
    • acute abdominal pain
    • abdominal distension
    • aphthous stomatitis
    • peripheral neuropathy
    • hypesthesia

    Rare or Very Rare Astagraf XL Side Effects

    Severe

    • malignant lymphoma
    • hemolytic uremic syndrome
    • anaphylaxis
    • idiopathic thrombocytopenic purpura
    • pancytopenia
    • squamous cell carcinoma
    • torsades de pointes
    • prolonged QT interval
    • transient blindness
    • left ventricular hypertrophy
    • gastric ulcer
    • gastroenteritis
    • hepatitis
    • acute pancreatitis
    • renal failure
    • Stevens-Johnson syndrome
    • posterior reversible encephalopathy syndrome
    • post-transplant lymphoproliferative disease
    • progressive multifocal leukoencephalopathy
    • interstitial lung disease
    • thrombocytopenic disorder
    • toxic epidermal necrolysis
    • abnormal ECG
    • disseminated intravascular coagulation
    • abnormal hepatic function tests
    • viral infection
    • BK polyomavirus reactivation nephropathy
    • pure red cell aplasia
    • agranulocytosis
    • hemolytic anemia
    • neutropenic disorder
    • thrombotic thrombocytopenic purpura
    • cytomegalovirus disease
    • chronic heart failure
    • bradycardia
    • gastrointestinal perforation
    • vision loss
    • biliary obstruction
    • cholangitis
    • hepatic necrosis
    • deep venous thrombosis
    • ventricular fibrillation
    • hemiparesis
    • rhabdomyolysis
    • hemorrhage
    • pulmonary hypertension
    • hemorrhagic cystitis
    • urinary retention
    • aphasia
    • paralysis
    • coma
    • pulmonary thromboembolism
    • leukocytosis
    • atrial fibrillation
    • atrial flutter
    • hypertrophic cardiomyopathy
    • pericardial effusion
    • angina
    • supraventricular premature beats
    • optic neuropathy
    • basal cell carcinoma of skin
    • flaccid paralysis

    Less Severe

    • hearing loss
    • glycosuria
    • impaired wound healing
    • mood changes
    • photophobia
    • myalgia
    • arthritis
    • skin pigmentation enhancement
    • pain in extremities
    • skin photosensitivity
    • rhinitis
    • hiccups
    • urinary incontinence
    • altered mental status
    • drowsy
    • dysarthria
    • syncope
    • delirium
    • hematuria
    • tachycardia
    • gastritis
  • Astagraf XL Storage

    Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Astagraf XL when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

IMPORTANT DISCLAIMER: All medical content is supplied by a third party company who is independent from this web site. As such, this web site can not guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdiction depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability.