Restasis Unit Dose

The active ingredient in Restasis is cyclosporine. Cyclosporine is an immunosuppressant, which means it suppresses the immune system to stop the white blood cells from attacking the body. Specifically, cyclosporine works as a calcineurin inhibitor that blocks calcineurin from working. This lowers inflammation and helps your eyes make more tears. It may not be effective for patients using topical anti-inflammatory medications or punctal plugs.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Restasis. However, the following is a synopsis of the general guidelines for the use of Restasis:

• One drop of Restasis should be administered twice a day in each eye, 12 hours apart for chronic dry eye.
• The single-dose vials should be kept in their original package until you are ready to use them. After instilling a drop in your eye(s), throw the vial away. Don't save any leftover medication or reuse them.
• Before using a new bottle of Restasis MultiDose, you have to prime the bottle by squeezing 2 drops onto a tissue. Do not let the tip of the bottle touch the tissue. Restasis MultiDose contains preservatives to prevent bacteria from growing, so it can be used more than once. Try not to touch the tip of the MultiDose bottle to avoid eye injury and/or contamination.
• Restasis is for ophthalmic use but should not be used while wearing eye contact lenses. You will need to take them out before using Restasis and then wait 15 minutes before putting them back in.
• If you miss your Restasis dosage, you can take it as soon as possible after you remember. However, if it’s almost time for your next dose, skip the missed dose. Then, take your next dose at the time you typically take it.

The most common side effects of Restasis include:

• Burning sensation in your eye
• Eye pain, stinging, swelling, redness, or irritation
• Blurred vision

Some individuals may experience serious side effects while using Restasis. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Allergic reaction
• Symptoms include hives, trouble breathing, and swelling.

These are not all of the possible side effects of Restasis. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Restasis, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Preexisting eye conditions
• Allergy to cyclosporine or any other ingredient in Restasis
• Any active infection, especially eye infection
• Punctal plugs
• A pregnancy, plan to become pregnant or are breastfeeding

Hypersensitivity to any ingredient in Restasis.

Restasis typically takes 3 to 6 months to improve tear production, but some people may notice benefits sooner. Consistent use as prescribed is essential for the medication to be effective.

When Restasis is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions. Currently, there are no noted drug interactions, however, if you are using other ophthalmic medications, such as artificial tears or other eye drops, it is recommended to wait at least 15 minutes between applications to prevent interference.

Restasis MultiDose and Restasis single-use vials come in a strength of 0.5 mg/mL.

Store Restasis single-use vials and MultiDose bottles at room temperature (15°C to 25°C or 59°F to 77°F) and protect them from light. Once a vial is opened, use it immediately and discard any remaining emulsion. MultiDose bottles can be reused as long as the expiration date has not passed.

It is manufactured by Allergan, Inc.

Yes, a generic version of the brand name Restasis (cyclosporine ophthalmic emulsion) is available.

Other common brands include Cequa, Vevye, and Verkazia.

To stop taking Restasis, consult your eye care provider to determine if discontinuation is appropriate for your condition. Stopping Restasis abruptly may cause symptoms of dry eye or dry eye disease to return if inflammation persists. Your doctor may suggest alternative treatments to maintain eye comfort and health.

Restasis is likely safe to take while pregnant. However, talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Restasis is generally considered safe during breastfeeding, as absorption into your bloodstream is likely minimal. However, talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.