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Buy Ziac Online
(Bisoprolol Fumarate/Hydrochlorothiazide)

What is Ziac?

What is Ziac?

Ziac (bisoprolol fumarate/hydrochlorothiazide) is a prescription medication used to treat high blood pressure (hypertension). It contains two medicines that work together to help lower blood pressure and improve heart health. Managing hypertension is important because uncontrolled high blood pressure can increase the risk of serious conditions such as heart failure, stroke, and kidney disease.

Ziac combines a beta blocker (bisoprolol fumarate) with a diuretic (hydrochlorothiazide), sometimes called a water pill. This combination helps reduce the workload on the heart and removes excess fluid from the body. By lowering blood pressure, Ziac may help reduce the risk of cardiovascular complications. Treatment with Ziac should be used as part of a complete care plan that may also include diet changes, regular exercise, and other recommendations from your healthcare provider.

Order Ziac online today and save!

Purchase Ziac from Universal Drugstore today and save!

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  • 2.5/6.25mg
  • 5/6.25mg
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Ziac brand

Ziac 
2.5/6.25mg

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Product of India

Product of India

Marketed as Lodoz in India.

Ziac 
5/6.25mg

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Prescription Required
Product of India

Product of India

Marketed as Lodoz in India.

Bisoprolol Fumarate/Hydrochlorothiazide (generic Ziac)

What are generics?

Bisoprolol Fumarate/Hydrochlorothiazide 
2.5/6.25mg

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Currently Unavailable

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Product of United States

Product of United States

Bisoprolol Fumarate/Hydrochlorothiazide 
5/6.25mg

Prescription Required
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Currently Unavailable

Prescription Required
Product of United States

Product of United States

Bisoprolol Fumarate/Hydrochlorothiazide 
10/6.25mg

Prescription Required
Select Quantity

Currently Unavailable

Prescription Required
Product of United States

Product of United States

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Important information about Ziac

The active ingredients in Ziac are bisoprolol fumarate and hydrochlorothiazide.

Bisoprolol fumarate is a beta blocker that affects the heart and blood vessels. It works by slowing the heart rate and reducing the force of the heart’s contractions. This helps the heart pump more efficiently and lowers blood pressure.

Hydrochlorothiazide, also known as HCTZ, is a thiazide diuretic. It helps the kidneys remove excess salt and water from the body through urine. Lowering fluid levels in the bloodstream helps decrease blood pressure and reduce swelling (edema) related to fluid retention.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Ziac. However, the following is a synopsis of the general guidelines for the use of Ziac:

  • Take Ziac exactly as prescribed by your healthcare provider.
  • It is usually taken once daily, with or without food, at the same time each day.
  • Swallow the tablet whole with water.
  • Continue taking the medication even if you feel well, since high blood pressure often has no symptoms.
  • If you miss a dose, take it as soon as you remember unless it is close to the time for your next dose. In that case, skip the missed dose and take the next dose at the regular time.

Some mild or common side effects of Ziac include:

  • Lightheadedness.
  • Slow heart rate (bradycardia).
  • Dizziness when standing (orthostatic hypotension).
  • Muscle cramps.
  • Constipation.
  • Mild electrolyte imbalances, such as low potassium levels (hypokalemia), low sodium levels (hyponatremia), low magnesium levels (hypomagnesemia), high calcium levels (hypercalcemia), or low chloride levels (hypochloremia), or high blood sugar levels (hyperglycemia).
  • Increased urination.

Some individuals may experience serious side effects while using Ziac. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Severe bradycardia.
  • Chest pain or worsening angina.
  • Bronchospasm.
  • Signs of electrolyte imbalance.
  • Allergic reactions, including rash, swelling, or trouble breathing.
  • May mask signs and increase risk for hypoglycemia (low blood sugar levels).
  • Severe skin reactions or unusual skin changes linked to skin cancer risk associated with long-term hydrochlorothiazide use.
  • Symptoms of gout due to hyperuricemia.

These are not all of the possible side effects of Ziac. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Ziac, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

  • Heart failure or arrhythmias.
  • Peripheral vascular disease.
  • Asthma or bronchospasm.
  • Diabetes.
  • Kidney disease.
  • Thyroid disorders.
  • Glaucoma.
  • Gout or high uric acid levels.
  • Electrolyte imbalances such as low potassium.

Because hydrochlorothiazide can increase sensitivity to sunlight, patients should consider using sunscreen and protective clothing when outdoors.

Ziac should not be used in certain situations, including:

  • Severe bradycardia.
  • Heart block greater than first degree without a pacemaker.
  • Cardiogenic shock.
  • Known hypersensitivity to bisoprolol, hydrochlorothiazide, or other sulfonamide-derived drugs.
  • Anuria (inability to produce urine).

Ziac may begin lowering blood pressure within a few hours after the first dose. However, full blood pressure control may take several weeks of consistent treatment. Regular monitoring helps determine how well the medication is working.

When Ziac is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.
  • Digoxin.
  • Clonidine or other antihypertensive drugs.
  • Cholestyramine or colestipol.
  • Corticosteroids.
  • Other beta blockers such as atenolol.
  • Epinephrine.

Ziac tablets are available in several strengths combining bisoprolol fumarate and hydrochlorothiazide. Common formulations include:

  • 2.5 mg bisoprolol / 6.25 mg hydrochlorothiazide.
  • 5 mg bisoprolol / 6.25 mg hydrochlorothiazide.
  • 10 mg bisoprolol / 6.25 mg hydrochlorothiazide.

Your healthcare provider will select the appropriate dose based on your response and blood pressure goals.

Store Ziac tablets at room temperature away from moisture and heat. Keep the medication in its original container and out of reach of children.

The brand-name medication Ziac was originally developed by Merck.

Generic versions are available under the generic name bisoprolol/hydrochlorothiazide.

Do not stop taking Ziac suddenly without speaking with your healthcare provider. Abrupt discontinuation of beta blockers may worsen heart conditions or cause chest pain. Your healthcare provider may gradually reduce your dose if treatment needs to be stopped.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you. Some medications that affect blood pressure may pose risks during pregnancy, so careful medical supervision is necessary.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you. Both bisoprolol and hydrochlorothiazide may pass into breast milk, and your healthcare provider can help determine the safest option.

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Important information about buying Ziac from UniversalDrugstore™

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.

Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Yes! We offer:

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  • 10% off your first order for new customers

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The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.