Trandate
(Labetalol Hydrochloride)Trandate Overview
Labetalol is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Trandate is both an alpha blocker and beta blocker. It works by blocking the action of certain natural chemicals in your body such as epinephrine on the heart and blood vessels. This effect lowers the heart rate, blood pressure, and strain on the heart.
Trandate Warnings
Do not stop taking Trandate without consulting your doctor. Some conditions may become worse when you suddenly stop Trandate. Some people who have suddenly stopped taking similar drugs have had chest pain, heart attack, and irregular heartbeat. If your doctor decides you should no longer use Trandate, your doctor may direct you to gradually decrease your dose over 1 to 2 weeks. When gradually stopping Trandate, it is recommended that you temporarily limit physical activity to decrease strain on the heart. Seek immediate medical attention if you develop chest pain/tightness/pressure, chest pain spreading to the jaw/neck/arm, unusual sweating, trouble breathing, or fast/irregular heartbeat.
How to Use Trandate
Take Trandate by mouth as directed by your doctor, usually twice a day. You may take Trandate with or without food, but it is important to choose one way and take Trandate the same way with every dose. Dosage of Trandate is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start Trandate at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Use Trandate regularly to get the most benefit from it. To help you remember, take it at the same times each day. For the treatment of high blood pressure, it may take several weeks before you get the full benefit of Trandate. Keep taking Trandate even if you feel well. Most people with high blood pressure do not feel sick. Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings remain high or increase).
Trandate Precautions
Before taking labetalol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Trandate may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Trandate, tell your doctor or pharmacist your medical history,heart problems (such as heart failure, slow heartbeat, second- or third-degree atrioventricular block), breathing problems (such as asthma, chronic bronchitis, emphysema), kidney disease, liver disease, overactive thyroid disease (hyperthyroidism), serious allergic reactions including those needing treatment with epinephrine, blood circulation problems (such as Raynaud's disease, peripheral vascular disease), mental/mood disorders (such as depression), a certain muscle disease (myasthenia gravis), certain eye problems (cataracts, glaucoma). Trandate may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Before having surgery (including cataract/glaucoma eye surgery), tell your doctor or dentist if you are taking or have ever taken Trandate, and about all the other products you use (including prescription drugs, nonprescription drugs, and herbal products). If you have diabetes, Trandate may mask the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness and sweating, are unaffected by Trandate. Trandate may also make it harder to control your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Children may be at greater risk for low blood sugar (hypoglycemia), especially if they are vomiting or not eating regularly. To help prevent low blood sugar, feed children on a regular schedule. If your child cannot eat regularly, is vomiting, or has symptoms of low blood sugar (such as sweating, seizures), stop Trandate and tell the doctor right away. Older adults may be more sensitive to the side effects of Trandate, including dizziness and lightheadedness. These side effects can increase the risk of falling. Labetalol has been used to treat high blood pressure in pregnant women. It is important to control high blood pressure for the health of the mother and unborn baby. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor the benefits and risks of using Trandate during pregnancy. Rarely, babies born to mothers who took labetalol during pregnancy may have symptoms of low blood pressure, slow heartbeat, slow breathing, and low blood sugar (such as shaking, unusual sweating) for a few days after delivery. Tell the doctor right away if you notice any of these symptoms in your newborn. Trandate passes into breast milk, and the effect on a nursing infant is unknown. Consult your doctor before breast-feeding.
Trandate Misdose
If you miss a dose of Trandate, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Trandate Interactions
See also Precautions section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.cimetidine, fingolimod. Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). Trandate may interfere with certain medical/laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Trandate.
Trandate Side Effects
See also Warning and Precautions sections. Dizziness and tiredness may occur. Scalp tingling may also occur as your body adjusts to the medication. Decreased sexual ability has been reported rarely. If any of these effects last or get worse, tell your doctor or pharmacist promptly. To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Trandate may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use. Remember that Trandate has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using Trandate do not have serious side effects. Tell your doctor right away if you have any serious side effects,very slow heartbeat, severe dizziness, fainting, blue fingers/toes, new or worsening symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain), mental/mood changes (such as confusion, mood swings, depression). Trandate may rarely cause serious (rarely fatal) liver disease. If you notice any of the following rare but serious side effects,nausea/vomiting that doesn't stop, severe stomach/abdominal pain, yellowing eyes/skin, dark urine. A very serious allergic reaction to Trandate is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Trandate Storage
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Trandate when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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